Correlation between Neutrophil-lymphocyte Ratio and Disease Activity in 536 Patients with Systemic Lupus Erythematosus

Lihua MA; Xiangyu WANG; Yifan YANG; Ruotong ZHAO; Xiaoyan FENG; Jian XU

doi:10.12259/j.issn.2095-610X.S20220209

Volume 43 Issue 2

Mar. 2022

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2022 > 43(2): 78-81

Lihua MA, Xiangyu WANG, Yifan YANG, Ruotong ZHAO, Xiaoyan FENG, Jian XU. Correlation between Neutrophil-lymphocyte Ratio and Disease Activity in 536 Patients with Systemic Lupus Erythematosus[J]. Journal of Kunming Medical University, 2022, 43(2): 78-81. doi: 10.12259/j.issn.2095-610X.S20220209

Citation:

Lihua MA, Xiangyu WANG, Yifan YANG, Ruotong ZHAO, Xiaoyan FENG, Jian XU. Correlation between Neutrophil-lymphocyte Ratio and Disease Activity in 536 Patients with Systemic Lupus Erythematosus[J]. Journal of Kunming Medical University, 2022, 43(2): 78-81. doi: 10.12259/j.issn.2095-610X.S20220209

Citation:

Lihua MA, Xiangyu WANG, Yifan YANG, Ruotong ZHAO, Xiaoyan FENG, Jian XU. Correlation between Neutrophil-lymphocyte Ratio and Disease Activity in 536 Patients with Systemic Lupus Erythematosus[J]. Journal of Kunming Medical University, 2022, 43(2): 78-81. doi: 10.12259/j.issn.2095-610X.S20220209

PDF( 636 KB)

Correlation between Neutrophil-lymphocyte Ratio and Disease Activity in 536 Patients with Systemic Lupus Erythematosus

doi: 10.12259/j.issn.2095-610X.S20220209

Dept. of Rheumatology and Immunology，the First Affiliated Hospital of Kunming MedicalUniversity，Kunming Yunnan 650032，China

Received Date: 2021-12-26
Available Online: 2022-02-24
Publish Date: 2022-03-04

Abstract

Abstract

Objective To assess the correlation between neutrophil-lymphocyte ratio （NLR） and the disease activity of systemic lupus erythematosus （SLE）. Methods A total of 536 patients with SLE from the Department of Rheumatology and Immunology of the First Affiliated Hospital of Kunming Medical University were selected. According to the SLE Disease Activity Index （SLEDAI） score, patients with SLE were divided into inactive group, lightly active group, moderately active group, and severely active group. The differences in NLR among the four groups were compared, and the correlation between NLR and SLEDAI score was analyzed through Spearman correlation analysis. Results There were differences in NLR levels among the four groups. The results of pairwise comparison showed that the NLR level of the moderately active group was higher than that of the inactive group （adjusted P < 0.001）; the NLR level of the severely active group was higher than that of the inactive group （adjusted P < 0.001）; the NLR level of the severely active group was higher than that of the lightly active group （P = 0.011 after adjustment）. The NLR of SLE patients were positively correlated with SLEDAI scores （P < 0.05）. Conclusion NLR can be used as a reference index to evaluate the disease activity of SLE patients.
- Systemic lupus erythematosus,
- Neutrophil-lymphocyte ratio,
- Disease activity

FullText(HTML)

References(13)

References

[1]	Carroll M. Innate immunity in the etiopathology of autoimmunity[J]. Nature Immunology,2001,2(12):1089-1090. doi: 10.1038/ni1201-1089
[2]	Muñoz L E,Janko C,Schulze C,et al. Autoimmunity and chronic inflammation -two clearance-related steps in the etiopathogenesis of SLE[J]. Autoimmunity Reviews,2010,10(1):38-42. doi: 10.1016/j.autrev.2010.08.015
[3]	Tsokos G C,Lo M S,Reis P C,et al. New insights into the immunopathogenesis of systemic lupus erythematosus[J]. Nature Reviews Rheumatology,2016,12(12):716-730. doi: 10.1038/nrrheum.2016.186
[4]	Ohmura K. Which is the best SLE activity index for clinical trials?[J]. Modern Rheumatology,2021,31(1):20-28. doi: 10.1080/14397595.2020.1775928
[5]	Seyit M,Avci E,Nar R,et al. Neutrophil to lymphocyte ratio,lymphocyte to monocyte ratio and platelet to lymphocyte ratio to predict the severity of COVID-19[J]. The American Journal of Emergency Medicine,2021,40(2):110-114.
[6]	Zhang A,Ning L,Han J,et al. Neutrophil-To-Lymphocyte Ratio as a Potential Biomarker of Neovascular Glaucoma[J]. Ocular Immunology and Inflammation,2021,29(2):417-424. doi: 10.1080/09273948.2019.1677916
[7]	Menon G,Johnson S E,Hegde A,et al. Neutrophil to lymphocyte ratio - A novel prognostic marker following spontaneous intracerebral haemorrhage[J]. Clinical Neurology and Neurosurgery,2021,200(1):106339.
[8]	Ma L,Zeng A,Chen B,et al. Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with systemic lupus erythematosus and their correlation with activity:A meta-analysis[J]. International Immunopharmacology,2019,76(1):e105949.
[9]	Qin B,Ma N,Tang Q,et al. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were useful markers in assessment of inflammatory response and disease activity in SLE patients[J]. Modern Rheumatology,2016,26(3):372-376. doi: 10.3109/14397595.2015.1091136
[10]	Hochberg M C. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus[J]. Arthritis and Rheumatism,1997,40(9):1725.
[11]	Ghang B,Kwon O,Hong S,et al. Neutrophil-to-lymphocyte ratio is a reliable marker of treatment response in rheumatoid arthritis patients during tocilizumab therapy[J]. Modern Rheumatology,2017,27(3):405-410. doi: 10.1080/14397595.2016.1214340
[12]	Yolbas S,Yildirim A,Gozel N,et al. Hematological Indices May Be Useful in the Diagnosis of Systemic Lupus Erythematosus and in Determining Disease Activity in Behçet’s Disease[J]. Medical Principles and Practice:International Journal of the Kuwait University,Health Science Centre,2016,25(6):510-516. doi: 10.1159/000447948
[13]	Seo J Y,Suh C H,Jung J Y,et al. The neutrophil-to-lymphocyte ratio could be a good diagnostic marker and predictor of relapse in patients with adult-onset Still's disease:A STROBE-compliant retrospective observational analysis[J]. Medicine,2017,96(29):7546. doi: 10.1097/MD.0000000000007546

Relative Articles(20)

Relative Articles

[1]	Chunli CHEN, Daolin CUI. Bioinformatics-Based Analysis of the Roles of MX1，IFI44， and STAT1 in Lupus Nephritis. Journal of Kunming Medical University, 2024, 46(): 1-10.
[2]	Hong ZHU, Qiong DU, Zhengwei ZHAO, Liping CHEN, Muli XU, Yungui TU. Analysis of Blood Cells and Establishment of Reference Interval of Elderly Derivative Index in Anning Area of Yunnan Province. Journal of Kunming Medical University, 2024, 45(6): 145-153. doi: 10.12259/j.issn.2095-610X.S20240620
[3]	Bowen TAN, Yun LIANG, Huan CHEN, Yi LEI, Yuhan WANG, Yan TIAN. The Prognostic Value of Preoperative Peripheral Blood Inflammatory Markers Combined with Tumor Markers in Resectable Colon Cancer Patients. Journal of Kunming Medical University, 2024, 45(12): 1-5.
[4]	Li LI, Ruixian ZHANG. Research Progress on The Potential Application of Circular RNA in Systemic Lupus Erythematosus. Journal of Kunming Medical University, 2024, 45(6): 161-165. doi: 10.12259/j.issn.2095-610X.S20240622
[5]	Feng SHEN, Yifan YANG, Ru BAI, Shu LI, Shuang LIU, Jian XU. Association between Systemic Immune-Inflammation Index and Disease Activity in Patients with Systemic Lupus Erythematosus. Journal of Kunming Medical University, 2024, 45(10): 45-49. doi: 10.12259/j.issn.2095-610X.S20241007
[6]	Jin-yun CAI, Juan WANG, Rui-xi SUN, Ping FU. Clinical Features of Rhupus Syndrome. Journal of Kunming Medical University, 2021, 42(2): 64-69. doi: 10.12259/j.issn.2095-610X.S20210201
[7]	Xue LOU, Li LIAO, Ruo-tong ZHAO, Xiang-yu WANG, Yi-fan YANG, Shuang LIU, Jian XU. Clinical Significance of Anti-dsDNA Antibody，Complement C3 and Other Laboratory Indicators in the Diagnosis of Renal Injury in Systemic Lupus Erythematosus. Journal of Kunming Medical University, 2021, 42(2): 49-53. doi: 10.12259/j.issn.2095-610X.S20210214
[8]	Li LIAO, Xue LOU, Ruo-tong ZHAO, Xiang-yu WANG, Yi-fan Yang, Shuang LIU, Jian XU. Correlation Between the Neutrophil-lymphocyte Ratio and Renal Damage in Systemic Lupus Erythematosus Patients. Journal of Kunming Medical University, 2021, 42(6): 72-75. doi: 10.12259/j.issn.2095-610X.S20210617
[9]	Huang Ying , Xu Kun Jing , Pu Dong , Li Xiao Fei , Chen Hai Yun , Wu Yan , Wang Li Hua , Li Wen Ming , Luo Yun , He Hua . . Journal of Kunming Medical University, 2019, 40(02): 116-122.
[10]	Chen Xian Wei , Lu Xiang Dong , Wang Yong Feng , Zhao Die Bo , Yang Xu , Wang Wen Xuan , Fan Yan Xin , Zhang Hui , Zhao Bin . . Journal of Kunming Medical University, 2019, 40(06): 76-79.
[11]	Chen Yi . Clinical Study of Glucosidorum Tripterygll Totorum Combined with Prednisone Acetate and Hydroxychloroquine Sulfate in Treatment of Systemic Lupus Erythematosus. Journal of Kunming Medical University, 2018, 39(03): 98-102.
[12]	Dai Bai Zhang , Ren Chao Feng , Zheng Qin Ling , Yang Yan Xia , Li Mei Hua . Changes in Composition of Lymphocytes in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Journal of Kunming Medical University, 2017, 38(06): 64-67.
[13]	Yuan Shan . . Journal of Kunming Medical University,
[14]	Xiao Xin . . Journal of Kunming Medical University,
[15]	Li Jing . . Journal of Kunming Medical University,
[16]	Zhang Li Guo . . Journal of Kunming Medical University,
[17]	Zhang Li Guo . . Journal of Kunming Medical University,
[18]	Yang Xiao Lei . . Journal of Kunming Medical University,
[19]	. Study on the Expression of CD45RO+ and CD45RA+T Lymphocytes in Peripheral Blood of Children Patients with Infectious Mononucleosis. Journal of Kunming Medical University,
[20]	Li Xiao Ming . . Journal of Kunming Medical University,