Correlation between Neutrophil-lymphocyte Ratio and Disease Activity in 536 Patients with Systemic Lupus Erythematosus

Lihua MA; Xiangyu WANG; Yifan YANG; Ruotong ZHAO; Xiaoyan FENG; Jian XU

doi:10.12259/j.issn.2095-610X.S20220209

Volume 43 Issue 2

Mar. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(2): 78-81

Lihua MA, Xiangyu WANG, Yifan YANG, Ruotong ZHAO, Xiaoyan FENG, Jian XU. Correlation between Neutrophil-lymphocyte Ratio and Disease Activity in 536 Patients with Systemic Lupus Erythematosus[J]. Journal of Kunming Medical University, 2022, 43(2): 78-81. doi: 10.12259/j.issn.2095-610X.S20220209

Citation:

Lihua MA, Xiangyu WANG, Yifan YANG, Ruotong ZHAO, Xiaoyan FENG, Jian XU. Correlation between Neutrophil-lymphocyte Ratio and Disease Activity in 536 Patients with Systemic Lupus Erythematosus[J]. Journal of Kunming Medical University, 2022, 43(2): 78-81. doi: 10.12259/j.issn.2095-610X.S20220209

Citation:

Lihua MA, Xiangyu WANG, Yifan YANG, Ruotong ZHAO, Xiaoyan FENG, Jian XU. Correlation between Neutrophil-lymphocyte Ratio and Disease Activity in 536 Patients with Systemic Lupus Erythematosus[J]. Journal of Kunming Medical University, 2022, 43(2): 78-81. doi: 10.12259/j.issn.2095-610X.S20220209

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Correlation between Neutrophil-lymphocyte Ratio and Disease Activity in 536 Patients with Systemic Lupus Erythematosus

doi: 10.12259/j.issn.2095-610X.S20220209

Dept. of Rheumatology and Immunology，the First Affiliated Hospital of Kunming MedicalUniversity，Kunming Yunnan 650032，China

Received Date: 2021-12-26
Available Online: 2022-02-24
Publish Date: 2022-03-04

Abstract

Abstract

Objective To assess the correlation between neutrophil-lymphocyte ratio （NLR） and the disease activity of systemic lupus erythematosus （SLE）. Methods A total of 536 patients with SLE from the Department of Rheumatology and Immunology of the First Affiliated Hospital of Kunming Medical University were selected. According to the SLE Disease Activity Index （SLEDAI） score, patients with SLE were divided into inactive group, lightly active group, moderately active group, and severely active group. The differences in NLR among the four groups were compared, and the correlation between NLR and SLEDAI score was analyzed through Spearman correlation analysis. Results There were differences in NLR levels among the four groups. The results of pairwise comparison showed that the NLR level of the moderately active group was higher than that of the inactive group （adjusted P < 0.001）; the NLR level of the severely active group was higher than that of the inactive group （adjusted P < 0.001）; the NLR level of the severely active group was higher than that of the lightly active group （P = 0.011 after adjustment）. The NLR of SLE patients were positively correlated with SLEDAI scores （P < 0.05）. Conclusion NLR can be used as a reference index to evaluate the disease activity of SLE patients.
- Systemic lupus erythematosus,
- Neutrophil-lymphocyte ratio,
- Disease activity

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References(13)

References

[1]	Carroll M. Innate immunity in the etiopathology of autoimmunity[J]. Nature Immunology,2001,2(12):1089-1090. doi: 10.1038/ni1201-1089
[2]	Muñoz L E,Janko C,Schulze C,et al. Autoimmunity and chronic inflammation -two clearance-related steps in the etiopathogenesis of SLE[J]. Autoimmunity Reviews,2010,10(1):38-42. doi: 10.1016/j.autrev.2010.08.015
[3]	Tsokos G C,Lo M S,Reis P C,et al. New insights into the immunopathogenesis of systemic lupus erythematosus[J]. Nature Reviews Rheumatology,2016,12(12):716-730. doi: 10.1038/nrrheum.2016.186
[4]	Ohmura K. Which is the best SLE activity index for clinical trials?[J]. Modern Rheumatology,2021,31(1):20-28. doi: 10.1080/14397595.2020.1775928
[5]	Seyit M,Avci E,Nar R,et al. Neutrophil to lymphocyte ratio,lymphocyte to monocyte ratio and platelet to lymphocyte ratio to predict the severity of COVID-19[J]. The American Journal of Emergency Medicine,2021,40(2):110-114.
[6]	Zhang A,Ning L,Han J,et al. Neutrophil-To-Lymphocyte Ratio as a Potential Biomarker of Neovascular Glaucoma[J]. Ocular Immunology and Inflammation,2021,29(2):417-424. doi: 10.1080/09273948.2019.1677916
[7]	Menon G,Johnson S E,Hegde A,et al. Neutrophil to lymphocyte ratio - A novel prognostic marker following spontaneous intracerebral haemorrhage[J]. Clinical Neurology and Neurosurgery,2021,200(1):106339.
[8]	Ma L,Zeng A,Chen B,et al. Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with systemic lupus erythematosus and their correlation with activity:A meta-analysis[J]. International Immunopharmacology,2019,76(1):e105949.
[9]	Qin B,Ma N,Tang Q,et al. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were useful markers in assessment of inflammatory response and disease activity in SLE patients[J]. Modern Rheumatology,2016,26(3):372-376. doi: 10.3109/14397595.2015.1091136
[10]	Hochberg M C. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus[J]. Arthritis and Rheumatism,1997,40(9):1725.
[11]	Ghang B,Kwon O,Hong S,et al. Neutrophil-to-lymphocyte ratio is a reliable marker of treatment response in rheumatoid arthritis patients during tocilizumab therapy[J]. Modern Rheumatology,2017,27(3):405-410. doi: 10.1080/14397595.2016.1214340
[12]	Yolbas S,Yildirim A,Gozel N,et al. Hematological Indices May Be Useful in the Diagnosis of Systemic Lupus Erythematosus and in Determining Disease Activity in Behçet’s Disease[J]. Medical Principles and Practice:International Journal of the Kuwait University,Health Science Centre,2016,25(6):510-516. doi: 10.1159/000447948
[13]	Seo J Y,Suh C H,Jung J Y,et al. The neutrophil-to-lymphocyte ratio could be a good diagnostic marker and predictor of relapse in patients with adult-onset Still's disease:A STROBE-compliant retrospective observational analysis[J]. Medicine,2017,96(29):7546. doi: 10.1097/MD.0000000000007546

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