Orthogonal Experiment for Optimization of Ultrasonic Extraction Process of Six Components from<i> Geranium wilfordii </i>Maxim

Kongchun SUN; Canyu YANG; Hongbo Zhang; Baochun SHEN

doi:10.12259/j.issn.2095-610X.S20220213

Volume 43 Issue 2

Mar. 2022

Turn off MathJax

Article Contents

Abstract

References

Relative Articles

Article Navigation > Journal of Kunming Medical University > 2022 > 43(2): 39-46

Effect of Drainage by Needle Puncturing into Hematoma and Urokinase Injection on Chronic Subdural Hematoma in 66 Cases[J]. Journal of Kunming Medical University, 2011, 32(09).

Citation:

Kongchun SUN, Canyu YANG, Hongbo Zhang, Baochun SHEN. Orthogonal Experiment for Optimization of Ultrasonic Extraction Process of Six Components from Geranium wilfordii Maxim[J]. Journal of Kunming Medical University, 2022, 43(2): 39-46. doi: 10.12259/j.issn.2095-610X.S20220213

Effect of Drainage by Needle Puncturing into Hematoma and Urokinase Injection on Chronic Subdural Hematoma in 66 Cases[J]. Journal of Kunming Medical University, 2011, 32(09).

Citation:

PDF( 947 KB)

Orthogonal Experiment for Optimization of Ultrasonic Extraction Process of Six Components from Geranium wilfordii Maxim

doi: 10.12259/j.issn.2095-610X.S20220213

1.
School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology Nature Products，Kunming Medical University，Kunming Yunnan 650500
2.
Mojiang County People’s Hospital，Puer Yunnan 654800，China

Received Date: 2021-12-27
Available Online: 2022-02-24
Publish Date: 2022-03-04

Abstract

Abstract

Objective T o optimize the ultrasonic extraction method for Geraniin, Gallic acid, Corilagin, Hyperoside, Ellagic acid, Protocatechuic acid from Geranium wilfordii Maxim by L₉（3⁴） orthogonal experiment. Methods On the basis of single factor experiments, using L₉（3⁴） orthogonal experiment, three main factors, methanol volume fraction, extraction time, solid-liquid ratio are chosen for three main component to study the effect of the interaction of various factors on the extraction rate of six components fromGeranium wilfordiiMaxim. Results The results show that the optimum extraction process are as follow: the methanol volume fraction was 60%, the solid-liquid ratio was 1∶10（g∶ml）, the extraction time was 40 min. Conclusion This method is simple, repeatability and accuracy. It can be to extract Geraniin, Gallic acid, Corilagin, Hyperoside, Ellagic acid, Protocatechuic acidfrom Geranium wilfordii Maxim.
- Geranium wilfordii Maxim,
- Ultrasonic Extraction,
- Orthogonal Experiment,
- HPLC

FullText(HTML)

References(15)

References

[1]	国家药典委员会. 中华人民共和国药典[S]. 北京: 中国医药出版社, 2020: 126.
[2]	罗宏,尹海波. 中药老鹳草的研究[J]. 长春中医药大学学报,2010,26(2):285-286.
[3]	车环宇,刘畅,孙仁爽. 老鹳草鞣质体外抗氧化作用研究[J]. 通化师范学院学报,2013,34(10):37-38. doi: 10.3969/j.issn.1008-7974.2013.10.012
[4]	李倩,买吾拉江·阿不都热衣木,徐芳,等. 老鹳草素药理研究进展[J]. 中国中医药信息杂志,2016,23(8):125-128. doi: 10.3969/j.issn.1005-5304.2016.08.034
[5]	王如意,刘纲勇,梁晓欣,等. HPLC法同时测定野老鹳草中5种活性成分的含量[J]. 中国药房,2016,27(21):2972-2975. doi: 10.6039/j.issn.1001-0408.2016.21.29
[6]	谷静逸,尹海波,赵容,等. 辽宁省5种老鹳草中5种活性成分的含量测定[J]. 中国实验方剂学杂志,2016,22(6):26-29.
[7]	曹波,尹海波,贾晓晴,等. HPLC 法同时测定3种老鹳草中7种成分[J]. 中成药,2016,38(6):1338-1342.
[8]	罗燕平,戚微岩,吴小东,等. 老鹳草素的研究进展[J]. 药物生物技术,2016,23(3):279-282.
[9]	江尚飞,潘伦,杨宗发,等. 中药有效成分常用提取新工艺研究进展[J]. 中国药业,2014,23(17):1-3.
[10]	王吉华,尹海波. 正交试验法优选老鹳草酚酸类成分的提取工艺[J]. 中药材杂志,2012,35(6):986-989.
[11]	刘娟,罗仓学,魏丽娜,等. 地椒总黄酮超声提取工艺优化及抗氧化活性研究[J]. 食品科技,2020,45(1):268-273.
[12]	翟豫州,王玉梅,王世杰,等. 正交实验法优化盐地碱蓬中多糖的超声提取工艺[J]. 广东化工,2021,48(15):29-31.
[13]	邓莹,刘杰,李香,等. 正交试验法优选玄参中肉桂酸的超声提取工艺[J]. 广东化工,2021,30(20):32-35.
[14]	潘娅,郑德俊. 正交试验法优选藤黄酸超声提取工艺[J]. 广东化工,2021,48(2):1-2.
[15]	彭华,宋霞,张春. 正交法优化‘胭脂萝卜’红色素超声提取工艺[J]. 中国农学通报,2021,37(27):132-138.

Relative Articles(20)

Relative Articles

[1]	Ning AN, Guang Liu, AiYun WANG, YangJin PAN, Ming ZHANG, Zhuo YU, Peng Chen. Therapeutic Effect and Mechanism of Geraniin on Experimental Osteoporotic Fracture in Rabbits. Journal of Kunming Medical University, 2024, 45(12): 10-18. doi: 10.12259/j.issn.2095-610X.S20241202
[2]	Yun HUANG, Annan ZHAO, Qiuyue LIU, Weimin GAO, Ji LI. Optimization of Extraction Technology of Narciclasine from Hymenocallis Littoralis Based on Response Surface Method. Journal of Kunming Medical University, 2023, 44(11): 22-28. doi: 10.12259/j.issn.2095-610X.S20231104
[3]	Na-na RONG, YU-feng LI, Li-yue REN, Yue-xin HU. Determination of Norfloxacin Glucose Injection in EDTA by RP-HPLC Method. Journal of Kunming Medical University, 2021, 42(8): 35-39. doi: 10.12259/j.issn.2095-610X.S20210807
[4]	Wu Le Yan , Hou Wen Qing , Sun Kong Chun , Yang Can Yu , Shu Wen , Shen Bao Chun . . Journal of Kunming Medical University, 2020, 41(06): 11-14.
[5]	Sun Kong Chun , Wu Le Yan , Hou Wen Qing , Yang Can Yu , Tang Yan Mei , Shen Bao Chun . . Journal of Kunming Medical University, 2020, 41(01): 1-10.
[6]	Zhang Xiao Chao , Yang Ren Hua , Shen Ying , He Hong Yan , Zhong Jin Ping , Shen Zhi Qiang , Chen Peng . Effects of Geraniin on Modulating the Expression of Cbfα 1 Gene in Rabbit Osteoporotic Fracture. Journal of Kunming Medical University, 2018, 39(08): 1-4.
[7]	Li Li . Effect of Geraniin on Expression of Wnt3a in BMSC from Osteoporotic Rats. Journal of Kunming Medical University,
[8]	Wang Yu Tao . . Journal of Kunming Medical University,
[9]	Sun Hong . . Journal of Kunming Medical University,
[10]	Xiao Yun . . Journal of Kunming Medical University,
[11]	He Jin . . Journal of Kunming Medical University,
[12]	Zhang Xiao Chao . . Journal of Kunming Medical University, 2012, 33(08): 1-1.
[13]	Liu Hai Bo . . Journal of Kunming Medical University,
[14]	Ding Lin Fen . . Journal of Kunming Medical University,
[15]	Ling Hong Qiong . . Journal of Kunming Medical University,
[16]	Zhou Shi Qiao . . Journal of Kunming Medical University,
[17]	Zheng Qiao Ling . . Journal of Kunming Medical University,
[18]	. Determination of Concentration of 5-Fluorouraci in Blood of Cancer Patients by HPLC. Journal of Kunming Medical University,
[19]	Yin Zhi Hua . The Optimum Conditions for Extration of Flavonoids and Polyphenols from Propolis. Journal of Kunming Medical University,
[20]	Su Xin Min . . Journal of Kunming Medical University,