Relationship between the MTHFR C677T Gene Polymorphism and the Collateral Circulation in Patients with Carotid Stenosis

Liya ZHANG; Juan BAO; Jiaping WANG; Yi CAO; Ri JING; Lei ZHANG; Wenqing ZHANG; Tianyi LI

doi:10.12259/j.issn.2095-610X.S20220219

Volume 43 Issue 2

Mar. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(2): 96-101

Liya ZHANG, Juan BAO, Jiaping WANG, Yi CAO, Ri JING, Lei ZHANG, Wenqing ZHANG, Tianyi LI. Relationship between the MTHFR C677T Gene Polymorphism and the Collateral Circulation in Patients with Carotid Stenosis[J]. Journal of Kunming Medical University, 2022, 43(2): 96-101. doi: 10.12259/j.issn.2095-610X.S20220219

Citation:

Liya ZHANG, Juan BAO, Jiaping WANG, Yi CAO, Ri JING, Lei ZHANG, Wenqing ZHANG, Tianyi LI. Relationship between the MTHFR C677T Gene Polymorphism and the Collateral Circulation in Patients with Carotid Stenosis[J]. Journal of Kunming Medical University, 2022, 43(2): 96-101. doi: 10.12259/j.issn.2095-610X.S20220219

Citation:

Liya ZHANG, Juan BAO, Jiaping WANG, Yi CAO, Ri JING, Lei ZHANG, Wenqing ZHANG, Tianyi LI. Relationship between the MTHFR C677T Gene Polymorphism and the Collateral Circulation in Patients with Carotid Stenosis[J]. Journal of Kunming Medical University, 2022, 43(2): 96-101. doi: 10.12259/j.issn.2095-610X.S20220219

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Relationship between the MTHFR C677T Gene Polymorphism and the Collateral Circulation in Patients with Carotid Stenosis

doi: 10.12259/j.issn.2095-610X.S20220219

The Sencond Affiliated Hospital，Kun Ming Medical University， Kunming, Yunnan Province 650101，China

Received Date: 2021-12-26
Publish Date: 2022-02-25

Abstract

Abstract

Objective To study the relationship between the MTHFR C677T gene polymorphism and the collateral circulation in patients with carotid stenosis. Methods A total of 65 patients with moderate or severe carotid stenosis and chronic occlusion diagnosed by DSA and 45 controls without carotid stenosis from October 2018 to March 2021 in our hospital were included. All patients completed general assessment. 65 patients with moderate or severe carotid stenosis and chronic occlusion were evaluated the collateral circulation ASITN grading by DSA . All patients completed MTHFR C677T genetic polymorphism test. Results The incidence of stroke in patients with moderate or severe carotid stenosis and chronic occlusion was significantly higher than that in control group. There were significant differences in age, smoking history, hypertension, diabetes, total cholesterol, low density cholesterol lipoprotein, homocysteine and CT/TT type of MTHFR C677T gene between carotid artery stenosis or chronic occlusion group and control group （P < 0.05）. The patients with good collateral circulation （ASITN grade 3-4） had high proportion of CC type in moderate or severe carotid stenosis and chronic carotid occlusion group. And the TT/TC type were more in patients with poor collateral circulation opening （ASITN grade 1-2） . Conclusions CT/TT type of MTHFR genotype is a risk factor for carotid stenosis. The collateral circulation of patients with CT/TT type is worse comparing with CC type in carotid stenosis.
- Carotid stenosis,
- MTHFR C677T gene polymorphism,
- Collateral circulation

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References(19)

References

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