Correlation of Lung Function and HRCT Bronchial Wall Thickness in Patients with Chronic Obstructive Pulmonary Disease

Qian HUANG; Meihua LI; Xiaojing TANG; Wei MA; Yanxia YANG; Qingling ZHENG; Jin HE

doi:10.12259/j.issn.2095-610X.S20220224

Volume 43 Issue 2

Mar. 2022

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2022 > 43(2): 118-121

Qian HUANG, Meihua LI, Xiaojing TANG, Wei MA, Yanxia YANG, Qingling ZHENG, Jin HE. Correlation of Lung Function and HRCT Bronchial Wall Thickness in Patients with Chronic Obstructive Pulmonary Disease[J]. Journal of Kunming Medical University, 2022, 43(2): 118-121. doi: 10.12259/j.issn.2095-610X.S20220224

Citation:

Qian HUANG, Meihua LI, Xiaojing TANG, Wei MA, Yanxia YANG, Qingling ZHENG, Jin HE. Correlation of Lung Function and HRCT Bronchial Wall Thickness in Patients with Chronic Obstructive Pulmonary Disease[J]. Journal of Kunming Medical University, 2022, 43(2): 118-121. doi: 10.12259/j.issn.2095-610X.S20220224

Citation:

Qian HUANG, Meihua LI, Xiaojing TANG, Wei MA, Yanxia YANG, Qingling ZHENG, Jin HE. Correlation of Lung Function and HRCT Bronchial Wall Thickness in Patients with Chronic Obstructive Pulmonary Disease[J]. Journal of Kunming Medical University, 2022, 43(2): 118-121. doi: 10.12259/j.issn.2095-610X.S20220224

PDF( 564 KB)

Correlation of Lung Function and HRCT Bronchial Wall Thickness in Patients with Chronic Obstructive Pulmonary Disease

doi: 10.12259/j.issn.2095-610X.S20220224

1.
Dept. of Respiratory and Critical Care Medicine，The First People’s Hospital of Kunming，Kunming Yunnan 650011
2.
Dept. of CT Division，The First People’s Hospital of Kunming，Kunming Yunnan 650011，China

Received Date: 2021-12-19
Available Online: 2022-02-24
Publish Date: 2022-03-04

Abstract

Abstract

Objective To investigate the correlation of pulmonary function indexes and bronchial wall thickness measured as computed with high resolution computed tomography in patients with chronic obstructive pulmonary diseases. Methods Eighty COPD patients were assigned to four groups based on the new COPD Global Initiative Classification, meanwhile, fifty normal people with physical examination in the hospital were selected as controls simultaneously. All subjects underwent chest HRCT scanning to measure the bronchial wall thickness at the bilateral apical bronchial opening, and the correlation between the bronchial wall thickness and lung function was studied. Results Bronbronchial wall thickness was significantly increased in COPD patients compared with normal population, and the difference was statistically significant （P < 0.05）. From the mild group to the very severe group, the bilateral bronchial wall thickness gradually increased, FEV1, FVC, FEV1/FVC gradually decreased, with statistically significant differences （P < 0.05）. Correlation analysis: bilateral bronchial wall thickness was significantly inversely associated with each index of lung function （P < 0.05）. Conclusions HRCT can be used to measure bronchial wall thickness and evaluate the degree of bronchial wall remodeling in COPD patients. With the deepening of the disease grade, the thickness of the bronchial wall of COPD patients gradually increased. There is a significant correlation between lung function indexes and bronchial wall thickness, that is, the thickening of bronchial wall, the decline of lung function indexes and the deterioration of lung function. HRCT measurement of bronchial wall thickness in COPD patients has clinical significance for the evaluation of the severity of the disease.
- Chronic obstructive pulmonary disease,
- High resolution computed tomography,
- Lung function,
- Bronchial wall thickness.

FullText(HTML)

References(12)

References

[1]	Vogelmeier C F,Criner G J,Martinez F J,et al. Global strategy for the diagnosis,management and prevention of chronic obstructive lung disease 2017 report:GOLD executive summary[J]. Respirology,2017,22:575-601. doi: 10.1111/resp.13012
[2]	Singh D,Agusti A,Anzueto A,et al. Global Strategy for the Diagnosis,Management,and Prevention of Chronic Obstructive Lung Disease:The GOLD Science Committee Report[J]. Eur Respir J,2019,53:1900164. doi: 10.1183/13993003.00164-2019
[3]	Murray C J,Lopez A D. Measuring the global burden of disease[J]. N Engl J Med,2013,369:448-457. doi: 10.1056/NEJMra1201534
[4]	GBD Chronic Respiratory Disease Collaborators. Prevalence and attributable health burden of chronic respiratory diseases,1990-2017:a systematic analysis for the Global Burden of Disease Study 2017[J]. Lancet Respir Med,2020,8(6):585-596. doi: 10.1016/S2213-2600(20)30105-3
[5]	Blasi F,Neri L,Centanni S,et al. Clinical characterization and treatment patterns for the frequent exacerbator phenotype in chronic obstructive pulmonary disease with severe or very severe airflow limitation[J]. COPD,2017,14(1):15-22. doi: 10.1080/15412555.2016.1232380
[6]	Rossi Andrea,Butorac-Petanjek Bojana,Chilosi Marco,et al. Chronic obstructive pulmonary disease with mild airflow limitation:current knowledge and proposal for future research - a consensus document from six scientific societies.[J]. Int J Chron Obstruct Pulmon Dis,2017,12:2593-2610. doi: 10.2147/COPD.S132236
[7]	Washko G R,Coxson H O,O'Donnell D E,et al. CT imaging of chronic obstructive pulmonary disease:insights,disappointments,and promise[J]. Lancet Respir Med,2017,5(11):903-908. doi: 10.1016/S2213-2600(17)30345-4
[8]	Petty T L,Weinmann G G. Building a national strategy for the prevention and management of and research in chronic obstructive pulmonary disease. National Heart,Lung,and Blood Institute Workshop Summary. Bethesda,Maryland,August 2931,1995[J]. JAMA,1997,277(3):246-253. doi: 10.1001/jama.1997.03540270072029
[9]	Lynch D A,Austin J H,Hogg J C,et al. CT-de fifinable subtypes of chronic obstructive pulmonary disease:a statement of the Fleischner Society[J]. Radiology,2015,277:192-205. doi: 10.1148/radiol.2015141579
[10]	Hogg J C,Macklem P T,Thurlbeck W M. Site and nature of airway obstruction in chronic obstructive lung disease[J]. N Engl J Med,1968,278:1355-1360.
[11]	Hogg J C,Chu F,Utokaparch S,et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease[J]. N Engl J Med,2004,350:2645-2653. doi: 10.1056/NEJMoa032158
[12]	Kumar I,Verma A,Jain A,et al. Performance of quantitative CT parameters in assessment of disease severity in COPD:A prospective study[J]. Indian J Radiol Imag,2018,28(1):99-106. doi: 10.4103/ijri.IJRI_296_17

Relative Articles(20)

Relative Articles

[1]	Su ZHANG, Zheng HUANG, Na LI, Jing XU, Yiting TAO. A Two Sample Mendelian Randomization Study on Nut Intake and Chronic Obstructive Pulmonary Disease. Journal of Kunming Medical University, 2024, 45(11): 81-86. doi: 10.12259/j.issn.2095-610X.S20241112
[2]	Kerong LI, Zhi ZHAO, Moxian CHEN, Lijuan AO, Fanyuan MENG. Pulmonary Function and Respiratory Muscle Strength in Mild to Moderate Adolescent Idiopathic Scoliosis Patients. Journal of Kunming Medical University, 2023, 44(7): 88-93. doi: 10.12259/j.issn.2095-610X.S20230707
[3]	Jinmei LU, Yuzhu LI, Lin WANG, Xin SU, Jinxiu LIN, Jianhui ZHANG. Study on the Effectiveness of Wearable Device-based Lung Rehabilitation in Patients with COPD. Journal of Kunming Medical University, 2023, 44(11): 175-182. doi: 10.12259/j.issn.2095-610X.S20231127
[4]	Linxia LI, Yanhong LI, Jie WU, Lili ZHANG, Xian ZHANG, Song WANG, Juntao ZHANG, Peng YAN. Studies on the Correlation between Serum Vitamin A, D and Lung Function in Infants with Asthmatic Pneumonia. Journal of Kunming Medical University, 2022, 43(1): 63-66. doi: 10.12259/j.issn.2095-610X.S20220114
[5]	Wei MA, Mei-hua LI, Xiao-jing TANG, Chao-feng REN, Yan-xia YANG, En-jie SI, Qian HUANG, Xiao-yi ZENG. Correlation between Pulmonary Artery Diameter by HRCT and Pulmonary Artery Pressure by Echocardiography in Patients with Chronic Obstructive Pulmonary Disease. Journal of Kunming Medical University, 2021, 42(6): 124-128. doi: 10.12259/j.issn.2095-610X.S20210643
[6]	Ye Xiu Lin , Yang Jiao , Li Min , Fang Yan , Tian Xi , Zhu Wen Zhuo . . Journal of Kunming Medical University, 2020, 41(02): 43-48.
[7]	He-ping LIU, Hong-mei WU, Yang LIU, Chun ZHANG, Wei-zhou WANG, Ding-yun YOU, Hong-xiang WU. Correlation between Anxiety Depression Symptoms of Patients with Chronic Obstructive Pulmonary Disease and CAT Score. Journal of Kunming Medical University, 2020, 41(12): 29-35. doi: 10.12259/j.issn.2095-610X.S20201212
[8]	Yang Xia , Feng Mei , Wu Ying , Zhu Jing . . Journal of Kunming Medical University, 2019, 40(08): 83-87.
[9]	Huang Li , Huang Xian Xiang . A Study of the Level Expression and Clinical Efficacy of Noninvasive Mechanical Ventilation in the Treatment of Insulin-like Growth Factor Ⅰ, Ⅱ and Cathepsin B in Patients with Chronic Obstructive Pulmonary Disease. Journal of Kunming Medical University, 2018, 39(08): 74-79.
[10]	Liu Jian Hong , Zhou Ji Bo . . Journal of Kunming Medical University, 2017, 38(03): 39-42.
[11]	Zhang Yang . Relationship between the Change of IL-8 and MMP-9 Levels in the Sputum/Serum and the Pulmonary Function in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease before and after Treatment. Journal of Kunming Medical University,
[12]	Bi Hong . The Analysis of Influential Factors of Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease in Kunming. Journal of Kunming Medical University,
[13]	Su Hui Peng . . Journal of Kunming Medical University,
[14]	Zeng Hai Ping . . Journal of Kunming Medical University,
[15]	Yang Huan Zhi . . Journal of Kunming Medical University,
[16]	Zhang Ji Hua . . Journal of Kunming Medical University,
[17]	Zhang Yang . . Journal of Kunming Medical University,
[18]	Dong Yu . . Journal of Kunming Medical University,
[19]	Liu Shi Chang . . Journal of Kunming Medical University,
[20]	. . Journal of Kunming Medical University,