Role of α7-nicotinic Acetylcholine Receptor in Occurrence，Development and Therapy of Lung Cancer

Qiao LUO; Hong SHI; Shaobo WANG

doi:10.12259/j.issn.2095-610X.S20220226

Volume 43 Issue 2

Mar. 2022

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Qiao LUO, Hong SHI, Shaobo WANG. Role of α7-nicotinic Acetylcholine Receptor in Occurrence，Development and Therapy of Lung Cancer[J]. Journal of Kunming Medical University, 2022, 43(2): 145-149. doi: 10.12259/j.issn.2095-610X.S20220226

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Qiao LUO, Hong SHI, Shaobo WANG. Role of α7-nicotinic Acetylcholine Receptor in Occurrence，Development and Therapy of Lung Cancer[J]. Journal of Kunming Medical University, 2022, 43(2): 145-149. doi: 10.12259/j.issn.2095-610X.S20220226

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Role of α7-nicotinic Acetylcholine Receptor in Occurrence，Development and Therapy of Lung Cancer

doi: 10.12259/j.issn.2095-610X.S20220226

Qiao LUO¹,
Hong SHI^{2
,
,},
Shaobo WANG^{1, 2
,
,}

1.
PET/CT Center，the First People Hospital of Yunnan Province，Affiliated Hospital of Kunming University of Science and Technology Kunming Yunnan 650100
2.
Institute of Primate Translational Medicine，Kunming University of Science and Technology，Kunming Yunnan 650504，China

Received Date: 2021-12-05
Available Online: 2022-02-24
Publish Date: 2022-03-04

Abstract

Abstract

Nicotinic acetylcholine receptors （nAChRs） are the central regulators of stimulatory and inhibitory neurotransmitters that control the synthesis and release of growth,angiogenic and neurotrophic factors incancer cells, the cancer microenvironment and distantmetastasis. Smoking and other possibly environmental and lifestyle factors increase the function of nAChRs that up-regulates carcinogenesis and down-regulates carcinostasis. α7-nAChRis particularly overexpressed in lung cancer cells, and participates in the proliferation, apoptosis and migration of cancer cells.Thus,α7-nAChR might be a new therapeutic target for lung cancer.
- α7-nAChR,
- Lung neoplasms,
- Molecular targeted therapy

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References(41)

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