Changes of Thyroid Function and Its Clinical Significance before and after Radiotherapy and Chemotherapy in Patients Undergoing Radical Breast Cancer Treatment

Jiawei LIAO; Xiaoqing HU; Yi YANG

doi:10.12259/j.issn.2095-610X.S20220229

Volume 43 Issue 2

Mar. 2022

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Jiawei LIAO, Xiaoqing HU, Yi YANG. Changes of Thyroid Function and Its Clinical Significance before and after Radiotherapy and Chemotherapy in Patients Undergoing Radical Breast Cancer Treatment[J]. Journal of Kunming Medical University, 2022, 43(2): 72-77. doi: 10.12259/j.issn.2095-610X.S20220229

Citation:

Jiawei LIAO, Xiaoqing HU, Yi YANG. Changes of Thyroid Function and Its Clinical Significance before and after Radiotherapy and Chemotherapy in Patients Undergoing Radical Breast Cancer Treatment[J]. Journal of Kunming Medical University, 2022, 43(2): 72-77. doi: 10.12259/j.issn.2095-610X.S20220229

Citation:

Jiawei LIAO, Xiaoqing HU, Yi YANG. Changes of Thyroid Function and Its Clinical Significance before and after Radiotherapy and Chemotherapy in Patients Undergoing Radical Breast Cancer Treatment[J]. Journal of Kunming Medical University, 2022, 43(2): 72-77. doi: 10.12259/j.issn.2095-610X.S20220229

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Changes of Thyroid Function and Its Clinical Significance before and after Radiotherapy and Chemotherapy in Patients Undergoing Radical Breast Cancer Treatment

doi: 10.12259/j.issn.2095-610X.S20220229

Dept. of Radiation Therapy，The Third Affiliated Hospital of Kunming Medical University，Yunnan Cancer Hospital，Kunming Yunnan 650118，China

Received Date: 2022-01-13
Available Online: 2022-02-24
Publish Date: 2022-03-04

Abstract

Abstract

Objective To analyze the changes of thyroid function and its clinical significance after chemotherapy and radiotherapy in patients undergoing radical surgery for breast cancer. Methods One hundred and six patients admitted to Yunnan Cancer Hospital from January 2015 to December 2018 with radical breast cancer undergoing chemotherapy and sternoclavicular combined field radiotherapy and regular review of thyroid function were selected as study subjects, and the thyroid function indexes of the patients were tested before chemotherapy, before radiotherapy, and 3, 6, 9, 12, 18 and 24 months after radiotherapy, respectively. The changes in hormone levels were observed. Results TSH was elevated in patients after radical breast cancer treatment 6 months after the end of radiotherapy compared with before chemotherapy（P < 0.05）. TG-Ab was elevated 12 months after the end of radiotherapy compared with before chemotherapy（P< 0.05）. TSH was elevated 3 months after the end of radiotherapy compared with before radiotherapy（P< 0.05）. TG-Ab and TPO-Ab were elevated 6 months after the end of radiotherapy compared with before radiotherapy（P < 0.05）. Conclusion Patients undergoing chemotherapy and radiation therapy for radical breast cancer can lead to the development of hypothyroidism and cause thyroid autoimmune reactions, which should be tested regularly and treated promptly.
- Thyroid function,
- Breast cancer,
- Chemotherapy; Radiotherapy

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