Value of Multiple Scoring Systems in Evaluating the Prognosis of Liver Cirrhosis Complicated with Esophageal and Gastric Varices Bleeding

Peizheng XIANG; Mengli LI; Yan FU

doi:10.12259/j.issn.2095-610X.S20220316

Volume 43 Issue 3

Mar. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(3): 128-134

Peizheng XIANG, Mengli LI, Yan FU. Value of Multiple Scoring Systems in Evaluating the Prognosis of Liver Cirrhosis Complicated with Esophageal and Gastric Varices Bleeding[J]. Journal of Kunming Medical University, 2022, 43(3): 128-134. doi: 10.12259/j.issn.2095-610X.S20220316

Citation:

Peizheng XIANG, Mengli LI, Yan FU. Value of Multiple Scoring Systems in Evaluating the Prognosis of Liver Cirrhosis Complicated with Esophageal and Gastric Varices Bleeding[J]. Journal of Kunming Medical University, 2022, 43(3): 128-134. doi: 10.12259/j.issn.2095-610X.S20220316

Citation:

Peizheng XIANG, Mengli LI, Yan FU. Value of Multiple Scoring Systems in Evaluating the Prognosis of Liver Cirrhosis Complicated with Esophageal and Gastric Varices Bleeding[J]. Journal of Kunming Medical University, 2022, 43(3): 128-134. doi: 10.12259/j.issn.2095-610X.S20220316

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Value of Multiple Scoring Systems in Evaluating the Prognosis of Liver Cirrhosis Complicated with Esophageal and Gastric Varices Bleeding

doi: 10.12259/j.issn.2095-610X.S20220316

1.
Dept. of Gastroenterology，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101
2.
Dept. of Respiratory Medicine，Affiliated Hospital of Yunnan University， Kunming Yunnan 650021，China

Received Date: 2022-01-19
Available Online: 2022-02-18
Publish Date: 2022-03-22

Abstract

Abstract

Objective To compare the values of AIMS65, GBS, MGBS, EGBS, CRS, CANUKA, Child-Turcotte-Pugh （CTP）, MELD, and MELD-Na scoring systems in the evaluation of the prognosis of patients with liver cirrhosis and EGVB, and explore the factors affecting the poor prognosis of patients with liver cirrhosis and EGVB. Methods A total of 169 patients diagnosed with liver cirrhosis and EGVB were divided into a good prognosis group and a poor prognosis group according to whether the patients had rebleeding or death in the hospital. The scores of each model at the time of admission of each patient were calculated, and the clinical characteristics of the two groups of patients were compared. Results There were 35 cases in the poor prognosis group and 134 cases in the good prognosis group. The scores of the poor prognosis group were higher than those of the good prognosis group. The AIMS65 score was the best in predicting whether the patient had a poor prognosis, and the difference was statistically significant （P < 0.05）. The HB and ALB in the good prognosis group were higher than those in the poor prognosis group, and the PT and INR were lower than those in the poor prognosis group. The difference was statistically significant （P < 0.05）. Multivariate logistic regression analysis suggested that ALB may be an independent protection factor for poor prognosis in patients with liver cirrhosis and EDVB. Conclusion AIMS65 is the best scoring system for prognostic evaluation of patients with liver cirrhosis and esophageal varices bleeding; ALB may be an independent protective factor for the poor prognosis of patients with liver cirrhosis and esophageal and gastric varices bleeding.
- Hepatic cirrhosis,
- Esophageal gastric variceal bleeding,
- Scoring system

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References(31)

References

[1]	Mouelhi L,Ayadi H,Zaimi Y,et al. Predictive scores of early mortality from variceal gastrointestinal bleeding in cirrhotic patients[J]. Tunis Med,2016,94(11):670-674.
[2]	肝硬化门静脉高压症食管、胃底静脉曲张破裂出血诊治专家共识（2019版）[J]. 中华外科杂志, 2019, 57（12）: 885-892.
[3]	Jeon H J,Moon H S,Kwon I S,et al. Which scoring system should be used for non-variceal upper gastrointestinal bleeding? Old or new?[J]. Gastroenterol Hepatol,2021,36(10):2819-2827. doi: 10.1111/jgh.15555
[4]	Stanley AJ,Laine L,Dalton HR,et al. International Gastrointestinal Bleeding Consortium. Comparison of risk scoring systems for patients presenting with upper gastrointestinal bleeding:international multicentre prospective study[J]. BMJ,2017,4(7):356-359.
[5]	Kawaguchi K,Isomoto H. Validation of AIMS65 to predict outcomes in acute variceal bleeding:Which risk scoring system outperforms in real practice?[J]. Dig Endosc,2020,32(5):739-741. doi: 10.1111/den.13657
[6]	Biselli M,Gramenzi A,Lenzi B,et al. Development and Validation of a Scoring System That Includes Corrected QT Interval for Risk Analysis of Patients With Cirrhosis and Gastrointestinal Bleeding[J]. Clin Gastroenterol Hepatol,2019,17(7):1388-1397. doi: 10.1016/j.cgh.2018.12.006
[7]	Tantai X X,Liu N,Yang L B,et al. Prognostic value of risk scoring systems for cirrhotic patients with variceal bleeding[J]. World J Gastroenterol,2019,25(45):6668-6680. doi: 10.3748/wjg.v25.i45.6668
[8]	Robertson M,Ng J,Abu Shawish W,et al. Risk stratification in acute variceal bleeding:Comparison of the AIMS65 score to established upper gastrointestinal bleeding and liver disease severity risk stratification scoring systems in predicting mortality and rebleeding[J]. Dig Endosc,2020,32(5):761-768. doi: 10.1111/den.13577
[9]	Motola-Kuba M,Escobedo-Arzate A,Tellez-Avila F,et al. Validation of prognostic scores for clinical outcomes in cirrhotic patients with acute variceal bleeding[J]. Ann Hepatol,2016,15(6):895-901.
[10]	Budimir I,Gradišer M,Nikolić M,et al. Glasgow Blatchford,pre-endoscopic Rockall and AIMS65 scores show no difference in predicting rebleeding rate and mortality in variceal bleeding[J]. Scand J Gastroenterol,2016,51(11):1375-1379. doi: 10.1080/00365521.2016.1200138
[11]	中华医学会肝病学分会. 肝硬化诊治指南[J]. 现代医药卫生,2020,36(2):1-19.
[12]	Saltzman John R,Tabak Ying P,Hyett Brian H,et al. A simple risk score accurately predicts in-hospital mortality,length of stay,and cost in acute upper GI bleeding[J]. Gastrointest Endosc,2011,74(6):1215-1224. doi: 10.1016/j.gie.2011.06.024
[13]	Blatchford O,Murray W R,Blatchford M. A risk score to predict need for treatment for upper-gastrointestinal haemorrhage[J]. Lancet,2000,356(9238):1318-1321. doi: 10.1016/S0140-6736(00)02816-6
[14]	Cheng D W,Lu Y W,Teller T,et al. A modified Glasgow Blatchford Score improves risk stratification in upper gastrointestinal bleed:a prospective comparison of scoring systems[J]. Aliment Pharmacol Ther,2012,36(8):782-789. doi: 10.1111/apt.12029
[15]	Laursen S B,Hansen J M,Schaffalitzky de Muckadell O B. The Glasgow Blatchford score is the most accurate assessment of patients with upper gastrointestinal hemorrhage[J]. Clin Gastroenterol Hepatol,2012,10(10):1130-1135. doi: 10.1016/j.cgh.2012.06.022
[16]	Rockall T A,Logan R F,Devlin H B,et al. Risk assessment after acute upper gastrointestinal haemorrhage[J]. Gut,1996,38(3):316-321. doi: 10.1136/gut.38.3.316
[17]	Oakland K,Kahan B C,Guizzetti L,et al. Development,validation,and comparative assessment of an international scoring system to determine risk of upper gastrointestinal bleeding[J]. Clin Gastroenterol Hepatol,2019,17(6):1121-1129. doi: 10.1016/j.cgh.2018.09.039
[18]	Huo T I,Wang Y W,Yang Y Y,et al. Model for end-stage liver disease score to serum sodium ratio index as a prognostic predictor and its correlation with portal pressure in patients with liver cirrhosis[J]. Liver Int,2007,27(4):498-506. doi: 10.1111/j.1478-3231.2007.01445.x
[19]	Morales-Arráez D,Ventura-Cots M,Altamirano J,et al. The MELD Score Is Superior to the Maddrey Discriminant Function Score to Predict Short-Term Mortality in Alcohol-Associated Hepatitis:A Global Study[J]. Gastroenterol,2022,117(2):301-310.
[20]	Ruf A E,Kremers W K,Chavez L L,et al. Addition of serum sodium into the MELD score predicts waiting list mortality better than MELD alone[J]. Liver Transpl,2005,11(3):336-343. doi: 10.1002/lt.20329
[21]	程家宁. 内镜联合药物诊治肝硬化食管-胃底静脉曲张破裂出血的疗效及再出血影响因素[J]. 临床普外科电子杂志,2021,9(4):26-30. doi: 10.3969/j.issn.2095-5308.2021.04.006
[22]	海静,罗和生. 几种非侵入性肝纤维化评分系统在肝硬化并食管胃底静脉曲张破裂出血组与非出血组间的比较[J]. 胃肠病学和肝病学杂志,2021,30(7):811-814+821.
[23]	苏争艳,孙超,蒋肸慧,等. 三种评分系统在肝硬化食管胃底静脉曲张破裂出血患者风险评估中的应用[J]. 中华消化内镜杂志,2020,37(2):105-110.
[24]	Mihas A A,Sanyal A J. Recurrent variceal bleeding despite endoscopic and medical therapy[J]. Gastroenterology,2004,127(2):621-629. doi: 10.1053/j.gastro.2004.05.060
[25]	江秋维,黄理,姚朝光. 乙型肝炎肝硬化并发食管胃底静脉曲张破裂出血患者临床特征及其危险因素分析[J]. 实用肝脏病杂志,2021,24(4):532-535. doi: 10.3969/j.issn.1672-5069.2021.04.020
[26]	余维微,蔡宗宗,曾耀明,等. 3种评分系统对肝硬化胃底食管静脉曲张出血患者预后的预测价值[J]. 重庆医学,2020,49(10):1623-1626+1630.
[27]	朱思奇,赵祥安,王甦. 肝硬化伴食管胃底静脉曲张出血的影响因素及3种模型对再出血的预测价值[J]. 实用临床医药杂志,2021,25(16):49-53.
[28]	Qi X,Su C,Ren W,et al. Association between portal vein thrombosis and risk of bleeding in liver cirrhosis:A systematic review of the literature[J]. Clin Res Hepatol Gastroenterol,2015,39(6):683-691. doi: 10.1016/j.clinre.2015.02.012
[29]	王亮. 肝硬化门静脉高压症术后门静脉血栓形成危险因素及干预措施分析[J]. 现代中西医结合杂志,2017,26(6):626-628. doi: 10.3969/j.issn.1008-8849.2017.06.020
[30]	Krige J E,Kotze U K,Distiller G,et al. Predictive factors for rebleeding and death in alcoholic cirrhotic patients with acute variceal bleeding:a multivariate analysis[J]. World J Surg,2009,33(10):2127-2135. doi: 10.1007/s00268-009-0172-6
[31]	Iino C,Shimoyama T,Igarashi T,et al. Usefulness of the Glasgow-Blatchford score to predict 1-week mortality in patients with esophageal variceal bleeding[J]. Eur J Gastroenterol Hepatol,2017,29(5):547-551. doi: 10.1097/MEG.0000000000000844

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