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Volume 43 Issue 4

Apr. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(4): 6-11

Yegang HU, Wei ZHANG. Role of Hereditary T Lymphocyte Immune Deficiency in Pulmonary Fibrosis Induced by Paraquat[J]. Journal of Kunming Medical University, 2022, 43(4): 6-11. doi: 10.12259/j.issn.2095-610X.S20220402

Citation:

Yegang HU, Wei ZHANG. Role of Hereditary T Lymphocyte Immune Deficiency in Pulmonary Fibrosis Induced by Paraquat[J]. Journal of Kunming Medical University, 2022, 43(4): 6-11. doi: 10.12259/j.issn.2095-610X.S20220402

Yegang HU, Wei ZHANG. Role of Hereditary T Lymphocyte Immune Deficiency in Pulmonary Fibrosis Induced by Paraquat[J]. Journal of Kunming Medical University, 2022, 43(4): 6-11. doi: 10.12259/j.issn.2095-610X.S20220402

Citation:

Yegang HU, Wei ZHANG. Role of Hereditary T Lymphocyte Immune Deficiency in Pulmonary Fibrosis Induced by Paraquat[J]. Journal of Kunming Medical University, 2022, 43(4): 6-11. doi: 10.12259/j.issn.2095-610X.S20220402

Role of Hereditary T Lymphocyte Immune Deficiency in Pulmonary Fibrosis Induced by Paraquat

doi: 10.12259/j.issn.2095-610X.S20220402

Yegang HU,
Wei ZHANG^,

Dept. of Critical Care Medicine，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2022-02-28
Available Online: 2022-03-23
Publish Date: 2022-04-25

Abstract

Objective To study the role of T lymphocyte immune deficiency in pulmonary fibrosis induced by paraquat. Methods BALB/C （nu/nu） nude mice and BALB/C （nu/+） mice were selected as experimental animal models. Paraquat was given 20 mg/kg by intragastric administration and paraquat concentration in plasma was determined by GC-MS 1 hour after administration. Lung tissues were obtained for pathological sections on the 7th and 28th day after administration by H&E and MASSON staining. Results There was no significant difference in plasma paraquat concentration of 2 strains of mice after 1 hour of exposure （P > 0.05） . H&E and MASSON staining of pathological sections on day 28th showed that there was statistical difference in the degree of fibrosis between the two strains （P < 0.05）. Conclusion T lymphocyte is involved in the pulmonary fibrosis caused by paraquat, but the loss of T lymphocytes does not completely avoid pulmonary fibrosis induced by paraquat. T lymphocyte immune deficiency is not the decisive factor of pulmonary fibrosis induced by paraquat.
- Paraquat,
- BALB/C （nu/nu） nude mice,
- T lymphocyte immune deficiency,
- GC-MS,
- Pulmonary-fibrosis

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