A Comparative Study of QCT and DXA on Detection of Osteoporosis in Postmenopausal Women

Hui MIAO; Ping JIANG; Zhenkai LOU; Longheng QIU; Ziran ZHOU; Chengyong LI; Bing WANG

doi:10.12259/j.issn.2095-610X.S20220407

Volume 43 Issue 4

Apr. 2022

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Hui MIAO, Ping JIANG, Zhenkai LOU, Longheng QIU, Ziran ZHOU, Chengyong LI, Bing WANG. A Comparative Study of QCT and DXA on Detection of Osteoporosis in Postmenopausal Women[J]. Journal of Kunming Medical University, 2022, 43(4): 55-61. doi: 10.12259/j.issn.2095-610X.S20220407

Citation:

Hui MIAO, Ping JIANG, Zhenkai LOU, Longheng QIU, Ziran ZHOU, Chengyong LI, Bing WANG. A Comparative Study of QCT and DXA on Detection of Osteoporosis in Postmenopausal Women[J]. Journal of Kunming Medical University, 2022, 43(4): 55-61. doi: 10.12259/j.issn.2095-610X.S20220407

Citation:

Hui MIAO, Ping JIANG, Zhenkai LOU, Longheng QIU, Ziran ZHOU, Chengyong LI, Bing WANG. A Comparative Study of QCT and DXA on Detection of Osteoporosis in Postmenopausal Women[J]. Journal of Kunming Medical University, 2022, 43(4): 55-61. doi: 10.12259/j.issn.2095-610X.S20220407

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A Comparative Study of QCT and DXA on Detection of Osteoporosis in Postmenopausal Women

doi: 10.12259/j.issn.2095-610X.S20220407

Dept. of Orthopaedics，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2022-02-11
Available Online: 2022-03-15
Publish Date: 2022-04-25

Abstract

Abstract

Objective To compare the detection rate of osteoporosis in postmenopausal women with quantitative computed tomography （QCT） and dual energy X-ray absorptiometry （DXA）, and analyze the causes for differences. Methods A total of 148 postmenopausal women were enrolled, with an average age of （63.7±10.4） years old. The lumbar spine bone mineral density was measured by DXA and QCT, respectively. The detection rate of osteoporosis by the two methods was calculated, and the measurement results were analyzed and compared. The plain CT images of patients with inconsistent diagnosis were checked to evaluate whether there were vertebral fracture, degenerative changes of spine and aorta abdominalis calcification. Results In 148 subjects, the detection rate of QCT was 45.9% （68/148）, and the detection rate of DXA was 26.4% （39/148）, the difference was statistically significant （P < 0.05）. The diagnosis of DXA and QCT was consistent in 92 subjects （62.2%）; the diagnosis of DXA and QCT was inconsistent in 56 subjects （37.8%）. 48.2% of the patients （27/56） were diagnosed as osteoporosis by QCT and bone mass reduction by DXA. 33.9% （19/56） of patients were diagnosed as bone mass reduction by QCT and normal bone mass by DXA. Of all patients with inconsistent diagnosis, 2 （2/56） had vertebral compression fractures, and 56 （56/56） had lumbar degeneration （osteophytes, endplate sclerosis, ligament ossification or facet joint osteoarthritis）, 9 （9/56） had abdominal aortic calcification. Conclusion The inconsistent detection rates of osteoporosis between QCT and DXA may be caused by the presence of spinal degeneration, abdominal aortic calcification and other sclerotic lesions, which will increase the BMD value of DXA, resulting in the higher detection rate of QCT than DXA. Compared with DXA, QCT is a more sensitive method for the diagnosis of osteoporosis in postmenopausal women.
- Postmenopausal women,
- Osteoporosis,
- Dual-energy X-ray absorptiometry,
- Quantitative computed tomography,
- Bone mineral density

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References(49)

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