Clinical Evaluation of Immune Function and SAA, MMP-9 and MMP-14 in Liver Injury Caused by Anti-Tuberculous Drugs

Nihong LU; Honglu LIU; Jiawei XIA; Yangjun CHEN; Linjun SHEN; Yongrui YANG; Jie LI

doi:10.12259/j.issn.2095-610X.S20220410

Volume 43 Issue 4

Apr. 2022

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2022 > 43(4): 50-54

Nihong LU, Honglu LIU, Jiawei XIA, Yangjun CHEN, Linjun SHEN, Yongrui YANG, Jie LI. Clinical Evaluation of Immune Function and SAA, MMP-9 and MMP-14 in Liver Injury Caused by Anti-Tuberculous Drugs[J]. Journal of Kunming Medical University, 2022, 43(4): 50-54. doi: 10.12259/j.issn.2095-610X.S20220410

Citation:

Nihong LU, Honglu LIU, Jiawei XIA, Yangjun CHEN, Linjun SHEN, Yongrui YANG, Jie LI. Clinical Evaluation of Immune Function and SAA, MMP-9 and MMP-14 in Liver Injury Caused by Anti-Tuberculous Drugs[J]. Journal of Kunming Medical University, 2022, 43(4): 50-54. doi: 10.12259/j.issn.2095-610X.S20220410

Citation:

Nihong LU, Honglu LIU, Jiawei XIA, Yangjun CHEN, Linjun SHEN, Yongrui YANG, Jie LI. Clinical Evaluation of Immune Function and SAA, MMP-9 and MMP-14 in Liver Injury Caused by Anti-Tuberculous Drugs[J]. Journal of Kunming Medical University, 2022, 43(4): 50-54. doi: 10.12259/j.issn.2095-610X.S20220410

PDF( 644 KB)

Clinical Evaluation of Immune Function and SAA, MMP-9 and MMP-14 in Liver Injury Caused by Anti-Tuberculous Drugs

doi: 10.12259/j.issn.2095-610X.S20220410

1.
Dept. of Respiratory and Critical Care Medicine
2.
Yunnan Provincial Clinical Medical Center for Infectious Diseases
3.
Dept. of Tuberculosis
4.
Dept. of Hepatology
5.
Medical examination center，Kunming Third People’s Hospital，Yunnan Province，Kunming Yunnan 650041，China

Received Date: 2022-01-01
Available Online: 2022-03-15
Publish Date: 2022-04-25

Abstract

Abstract

Objective To explore the changes of immune function in patients with anti-tuberculous drug-induced liver injury （ATB-DILI）, and to explore the clinical value and application significance of serum amylase A （SAA）, matrix metalloproteinase 9 （MMP-9） and matrix metalloproteinase 14 （MMP-14） in anti-tuberculosis drug liver injury. Methods A total of 115 patients with anti-tuberculosis drug-induced liver injury admitted to the Third People’ s Hospital of Kunming from July 2019 to July 2020 were selected. Based on types of liver injury, the patients were divided into 4 subgroups A, B, C and D, and 35 healthy subjects underwent health check during the same period were selected as control group （group E）. The changes and expression levels of immune function, SAA, MMP-9 and MMP-14 in different subgroups were compared, as well as their relationship with ATB-DILI severity grade. Results The CD4⁺ count of group A patients was lower than that of group E, and the difference was statistically significant （P < 0.05）. The expression levels of SAA and MMP-9 in gronp A were higher than the other three groups, and the difference between the groups was statistically significant （P < 0.05）. The expression of MMP-14 in group C was higher than that of the other three groups, and the difference was statistically significant （P < 0.05）. SAA and MMP-9 were correlated with the severity of anti-tuberculosis drug liver injury （r = 0.687, P < 0.05; r = 0.811, P < 0.05）. Conclusion CD4⁺ counts were reduced in some patients with ATB-DILI, suggesting that these patients have low immune function, and the impaired immune function may be related to liver injury. SAA, MMP-9 and MMP-14 increased in different degrees in patients with different types of anti-tuberculosis drug liver injury. The severity of liver injury is closely related to the expression of SAA and MMP-9. SAA, MMP-9 and MMP-14 are expected to be the evaluation indicators of the severity of clinical ATB-DILI.
- Immune function,
- Serum amyloid A,
- Matrix mctalloprotcinase-9,
- Matrix mctalloprotcinase-14,
- Anti-tuberculosis drug-induced liver injury,
- Evaluation value

FullText(HTML)

References(25)

References

[1]	迟旭,漆沄,陈娟,等. 初次抗结核治疗诱发药物性肝损伤临床特点及发病危险因素的Logistic回归分析[J]. 陕西医学,2019,48(1):67-70.
[2]	中国中西医结合学会检验医学专业委员会. 血清淀粉样蛋白A在感染性疾病中临床应用的专家共识[J]. 中华检验医学杂志,2019,42(3):186-192.
[3]	刘明明,李爱玲,修瑞娟. 基质金属蛋白酶的研究进展[J]. 中国病理生理杂志,2018,34(10):1914-1920. doi: 10.3969/j.issn.1000-4718.2018.10.029
[4]	周志亮,王淳良. 基质金属蛋白酶-9在胶质瘤中的研究进展[J]. 健康必读,2021,16(1):259-260.
[5]	中华医学会结核病学分会. 抗结核药物性肝损伤诊治指南(2019年版)[J]. 中华结核和呼吸杂志,2019,36(10):343-356.
[6]	中华人民共和国国家卫生和计划生育委员会. wS288～2017肺结核诊断[S]. 北京: 人民卫生出版社, 2017.
[7]	孟佩佩,刘世坤,何阳,等. 144例药物性肝损伤的临床特点及影响因素分析[J]. 中国临床药理学杂志,2017,33(5):467-469.
[8]	吴于清,钟诚,黄燕群,等. CD4+CD25+调节性T细胞在抗结核药物所致的肝损伤中的作用[J]. 结核病与肝部健康杂志,2017,6(2):125-127.
[9]	马小云,白满灵. 113例抗结核药物致患者药物性肝损伤临床观察[J]. 药学研究,2020,49(2):82-84.
[10]	刘成刚,谢恬,张坤江,等. 新疆维吾尔族、汉族抗结核药物性肝损伤患者NO及NOS表达水平的研究[J]. 中国感染控制杂志,2018,17(4):283-288. doi: 10.3969/j.issn.1671-9638.2018.04.002
[11]	黄洁,王晖,周蜜. T淋巴细胞亚群在抗结核药物所致肝损伤中的作用[J]. 江西医药,2018,53(4):393-394. doi: 10.3969/j.issn.1006-2238.2018.4.039
[12]	王贺,李仕来,朱继金. 细胞自噬在脓毒症肝损伤中的研究进展[J]. 中国急救医学,2021,41(1):87-90. doi: 10.3969/j.issn.1002-1949.2021.01.017
[13]	陶叶海. 抗结核急性药物性肝损伤患者外周血CD8+T细胞上CD28表达及意义[J]. 上海预防医学,2014,26(11):626-628.
[14]	Sack G H,Jr. Serum amyloid A - a review[J]. Mol Med,2018,24(1):1-27. doi: 10.1186/s10020-018-0047-0
[15]	Yuzhalin A E,Lim S Y,Kutikhin A G,et al. Dynamic matrisome:ECM remodeling factors licensing cancer progression and metastasis[J]. Biochim Biophys Acta Rev Cancer,2018,1870(2):207-228. doi: 10.1016/j.bbcan.2018.09.002
[16]	吴启文,陈玉成. 门冬氨酸鸟氨酸联合异甘草酸镁治疗抗结核药所致药物性肝损伤临床研究[J]. 岭南急诊医学杂志,2020,25(3):243-245. doi: 10.3969/j.issn.1671-301X.2020.03.012
[17]	孙勤,肖和平. 抗结核药物所致肝损伤分子遗传机制的探讨[J]. 中华结核和呼吸杂志,2018,41(1):10. doi: 10.3760/cma.j.issn.1001-0939.2018.01.005
[18]	徐杨,熊英琼. 基质金属蛋白酶9和血管内皮生长因子对缺血性脑卒中的影响[J]. 中国医药导报,2020,17(3):41-44.
[19]	De Buck M,Gouwy M,Wang J M,et al. Structure and expression of different serum amyloid A (SAA) variants and their concentration-dependent functions during host insults[J]. Curr Med Chem,2016,23(17):1725-1755. doi: 10.2174/0929867323666160418114600
[20]	刘朋. 急性脑卒中患者血清MMP-9、Hcy及Lp(a)水平变化及临床意义分析[J]. 实用中西医结合临床,2021,21(6):123-124.
[21]	Cui G,Cai F,Ding Z,et al. MMP14 predicts a poor prognosis in patients with colorectal cancer[J]. Hum Pathol,2019,83(18):36-42.
[22]	杨涛,苏忠,杨奕,等. 肝细胞癌组织中基质金属蛋白酶14的表达及其与预后的关系[J]. 东南大学学报(医学版),2021,40(1):63-68. doi: 10.3969/j.issn.1671-6264.2021.01.012
[23]	Xiao G,Wang P,Zheng X,et al. FAM83A-AS1 promotes lung adenocarcinoma cell migration and invasion by targeting miR-150-5p and modifying MMP14[J]. Cell Cycle,2019,18(21):2972-2985. doi: 10.1080/15384101.2019.1664225
[24]	吐尔逊江·艾力,曹国磊,陈慧芳,等. miR-9和MMP-14在非小细胞肺癌中的表达及临床意义[J]. 临床肿瘤学杂志,2021,26(6):554-558. doi: 10.3969/j.issn.1009-0460.2021.06.013
[25]	Filipe E C,Chitty J L,Cox T R. Charting the unexplored extracellular matrix in cancer[J]. Int J Exp Pathol,2018,99(2):58-76. doi: 10.1111/iep.12269

Relative Articles(20)

Relative Articles

[1]	Congxin LI, Haidong YUE, Pengxi ZHU, Guangxian HUANG, Lingjie MU, Yanan PENG, Yijie WANG, Yang YANG. Correlation analysis between different vitamin D levels and immune inflammatory indicators in elderly patients with sepsis. Journal of Kunming Medical University, 2024, 46(): 1-9.
[2]	Zhiye QI, Ying CHEN, Yan LI. Research Progress on Immunotoxicology of Pyrethroid Pesticides Exposures. Journal of Kunming Medical University, 2024, 45(8): 154-160. doi: 10.12259/j.issn.2095-610X.S20240822
[3]	Jihong LIU, Zhiqiang MA, Lin WANG, Xiaoyan WANG, Weiguang TIAN, Baoping LI, Rui DONG, Yujia LV. Correlation Analysis of Immune Function of Tuberculosis Patients Infected with COVID-19. Journal of Kunming Medical University, 2024, 45(4): 157-162. doi: 10.12259/j.issn.2095-610X.S20240423
[4]	Xuejiao WU, Jiangli PENG, Hao FAN, Lu WANG, Jie CHEN, Hui LIU. Clinical Features and Prognostic Factors of 310 Patients with Antituberculosis Drug-induced Liver Injury. Journal of Kunming Medical University, 2024, 45(3): 157-165. doi: 10.12259/j.issn.2095-610X.S20240324
[5]	Nihong LU, Honglu LIU, Yangjun CHEN, Yaping SUN, Yan YANG, Yongrui YANG, Jie LI. The Association between ESAT-6 Combined Multiple Detection Indicators and the Severity of Anti-tuberculosis Drug-induced Liver Injury. Journal of Kunming Medical University, 2024, 45(8): 52-57. doi: 10.12259/j.issn.2095-610X.S20240808
[6]	Ying ZHANG, Fengxia YANG, Jing GUO, Qingling ZHANG. Effects of Systematic Psychological Intervention Based on S-ABC Framework on Perioperative Psychological Distress and Immune Function in Patients with Primary Liver Cancer. Journal of Kunming Medical University, 2023, 44(11): 170-174. doi: 10.12259/j.issn.2095-610X.S20231126
[7]	Lin WANG, Lingjun SHEN, Haiwen LI, Xiaoyan WANG, Jianpeng GAO, Zhiqiang MA. Analysis of Nutritional Status and Immune Function of Tuberculosis Patients in Yunnan. Journal of Kunming Medical University, 2023, 44(1): 109-115. doi: 10.12259/j.issn.2095-610X.S20230116
[8]	Yanlong LIU, Xuefeng GUANG, Xiaolong YIN, Hailong DAI. Effects of miR-125a-3p on Atherosclerotic Plaque, M1/M2 Macrophages, MMP-9 and VEGF. Journal of Kunming Medical University, 2022, 43(9): 1-6. doi: 10.12259/j.issn.2095-610X.S20220915
[9]	Yubin LE, Shikui GUO. The Value of Serum Adipokine in the Long-term Prognosis of Colorectal Cancer Patients. Journal of Kunming Medical University, 2022, 43(4): 82-88. doi: 10.12259/j.issn.2095-610X.S20220417
[10]	Ni-hong LU, Hong-lu LIU, Yang-jun CHEN, Yan YANG, Yong-rui YANG, Ying-rong DU. Characteristics of Infection Indexes in Patients with Antituberculous Drug-induced Liver Injury. Journal of Kunming Medical University, 2021, 42(11): 57-61. doi: 10.12259/j.issn.2095-610X.S20211111
[11]	Cheng Min , Shi Kai De , Liu Xing . . Journal of Kunming Medical University, 2017, 38(02): 86-89.
[12]	Li Lan Jiang , Xu Bing Ying , Yang Chun Yan , Zhao Chuan , Tian Xin . Correlative Studies between MMP1 Gene Polymorphism and the Risk of Oral Squamous Cell Carcinomas among Han Nationality in Yunnan Province. Journal of Kunming Medical University, 2017, 38(07): 73-75.
[13]	Yang Ke , Dan Zu Jian , Zhou Qiong Hua , Wang Jun Feng . Relationship between Soluble Cytokine Receptors, Matrix Metalloproteinases and Pancreatic Cancer. Journal of Kunming Medical University, 2017, 38(01): 99-102.
[14]	Liang Nai Chao . Correlation between Expression of MMP-9， TIMP-1 and VEGF and the Invasion of Non Small Cell Lung Cancer. Journal of Kunming Medical University,
[15]	Hong Xu Hua . Effects of Tuberculosis Drugs Combined with Rifapentine on the Immune Function， Inflammatory Factors， VEGF and MMP-9 of TB Patients. Journal of Kunming Medical University,
[16]	Du Ming . . Journal of Kunming Medical University, 2013, 34(12): 1-1.
[17]	Lin Yan . . Journal of Kunming Medical University,
[18]	Gu Xin . . Journal of Kunming Medical University,
[19]	Shen Li Da . . Journal of Kunming Medical University,
[20]	Zhang Yan Li . . Journal of Kunming Medical University,