The Value of Serum Adipokine in the Long-term Prognosis of Colorectal Cancer Patients

Yubin LE; Shikui GUO

doi:10.12259/j.issn.2095-610X.S20220417

Volume 43 Issue 4

Apr. 2022

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Yubin LE, Shikui GUO. The Value of Serum Adipokine in the Long-term Prognosis of Colorectal Cancer Patients[J]. Journal of Kunming Medical University, 2022, 43(4): 82-88. doi: 10.12259/j.issn.2095-610X.S20220417

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Yubin LE, Shikui GUO. The Value of Serum Adipokine in the Long-term Prognosis of Colorectal Cancer Patients[J]. Journal of Kunming Medical University, 2022, 43(4): 82-88. doi: 10.12259/j.issn.2095-610X.S20220417

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The Value of Serum Adipokine in the Long-term Prognosis of Colorectal Cancer Patients

doi: 10.12259/j.issn.2095-610X.S20220417

Yubin LE^{1, 2},
Shikui GUO^{2
,
,}

1.
Medical School，Kunming University of Science and Technology Kunming Yunnan 650500
2.
Dept. of General Surgery，The 1st People’s Hospital of Yunnan Province， Kunming Yunnan 650032，China

Received Date: 2022-02-13
Available Online: 2022-03-15
Publish Date: 2022-04-25

Abstract

Abstract

Objective To evaluate the value of serum adipokine in the long-term prognosis of colorectal cancer. Methods 80 patients with colorectal cancer were selected as the study subjects, and 80 healthy subjects were selected as the control group. Serum adipokine levels were compared between the two groups and the patients with different pathological characteristics of colorectal cancer tumors. The 5-year overall survival rate was calculated and the survival curve was drawn. Correlation analysis, multivariate analysis and the prediction efficiency of adipokine on 5-year survival were compared. Results Compared with the control group, the levels of visfatin and leptin in colorectal cancer patients were significantly increased （P < 0.05）, and the levels of adiponectin were significantly decreased （P < 0.05）. There were statistically significant differences in the levels of visfatin, adiponectin and leptin in different stages of tumor differentiation and TNM （P < 0.05）. The results of survival curve showed that the 5-year survival time distribution of patients with different concentrations of visfatin, adiponectin and leptin was significantly different （χ² = 4.715, 4.530, 7.011, P = 0.030, 0.033, 0.008）. Correlation analysis results show that adiponectin was significantly negatively correlated with tumor differentiation, TNM stage and 5-year overall survival rate （P < 0.05）, leptin was significantly positively correlated with tumor differentiation, TNM stage and 5-year overall survival rate （P < 0.05）, while visfatin was not significantly correlated with tumor differentiation and TNM stage （P > 0.05）. There was significant positive correlation with 5-year overall survival rate （P < 0.05）. Multivariate analysis showed that visfatin and leptin were the risk factors for five-year survival of colorectal cancer patients, while adiponectin was the protective factor. The results of ROC curve showed that the AUC, sensitivity and specificity of the combined prediction of the three indexes were higher than those of the independent prediction. Conclusion Visfatin and leptin are risk factors for 5a survival in colorectal cancer patients, while adiponectin is a protective factor. The combination of these indicators has higher efficacy in predicting 5-year survival.
- Adipokine,
- Colorectal cancer,
- Long-term prognosis,
- Assessed value

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References(27)

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