Volume 43 Issue 4
Apr.  2022
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Ying ZHANG, Hong GAO, Cuixiang ZHANG, Zeying CHEN, Hongqun ZOU, Liqiong LI, Jupin YANG, Yuexin HU. Helicobacter Pylori Infection in Children and its Correlation with Iron Deficiency Anemia[J]. Journal of Kunming Medical University, 2022, 43(4): 103-106. doi: 10.12259/j.issn.2095-610X.S20220418
Citation: Ying ZHANG, Hong GAO, Cuixiang ZHANG, Zeying CHEN, Hongqun ZOU, Liqiong LI, Jupin YANG, Yuexin HU. Helicobacter Pylori Infection in Children and its Correlation with Iron Deficiency Anemia[J]. Journal of Kunming Medical University, 2022, 43(4): 103-106. doi: 10.12259/j.issn.2095-610X.S20220418

Helicobacter Pylori Infection in Children and its Correlation with Iron Deficiency Anemia

doi: 10.12259/j.issn.2095-610X.S20220418
  • Received Date: 2021-12-01
    Available Online: 2022-03-23
  • Publish Date: 2022-04-25
  •   Objectives   To investigate the infection of H.pylori in 528 children with epigastric pain in Dali Bai Autonomous Prefecture People’s Hospital, to study the correlation between infection and iron deficiency anemia (IDA) and to provide evidence for the diagnosis and treatment of H.pylori infection and IDA in children.  Method   A total of 528 children aged 3 to 13 who received 13C-UBT due to upper abdominal pain in the outpatient department of Dali Bai Autonomous Prefecture People’ s Hospital from January 2019 to December 2020 were selected, and the gender and ethnicity of the detected children were analyzed by questionnaire. There were 119 H.pylori positive children listed as the observation group, and 409 H.pylori negative children listed as the control group. Hemoglobin (Hb), mean red blood cell Volume (MCV), serum iron (SI) , total iron binding capacity (TIBC) and serum ferritin (SF) were tested to determine the occurrence of IDA, and the correlation between H.pylori infection and IDA was analyzed.  Results   The total infection rate of H.pylori in 528 children was 22.53%, and the positive rates of H.pylori in male and female children were 22.88% and 22.22%, respectively. There was no significant difference in the positive rate of H.pylori in male and female children (χ2 = 0.08, P > 0.05). The positive rates of H.pylori infection in Han, Bai, Tibetan and other minority children were 17.95%, 20.69%, 64.29% and 26.92%, respectively. The positive rate of H.pylori infection was significantly different (χ2 = 273.659, P < 0.01). The levels of Hb, MCV, SI and SF in the observation group were significantly lower than those in the control group, and the level of TIBC was significantly higher than that in the control group, with statistical significance (P < 0.05).  Conclusion  H.pylori infection rate was not related to gender, and there were obvious ethnic clusters. H.pylori infection is associated with IDA in children and may be a risk factor for IDA. Therefore, routine H pylori monitoring and anti-H.pylori treatment should be included in the clinical treatment of IDA to obtain better clinical outcome.
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  • [1]
    魏思思,赵连梅. 幽门螺杆菌的治疗现状和研究进展[J]. 河北医科大学学报,2017,38(7):861-865. doi: 10.3969/j.issn.1007-3205.2017.07.031
    [2]
    李兴川,王海东,张妮,等. 中国儿童及青少年幽门螺杆菌感染流行病学调查的系统评价和meta分析[J]. 临床儿科杂志,2017,35(10):782-787. doi: 10.3969/j.issn.1000-3606.2017.10.016
    [3]
    Ding Z,Zhao S,Gong S,et al. Prevalence and risk factors of Helicobacter pylori infection in asymptomatic Chinese children:A prospective,cross -sectional,population-based,study[J]. Aliment Pharmacol T her,2015,42(8):1019-1026. doi: 10.1111/apt.13364
    [4]
    Ueda J,Yamaguchi A,Shibasaki K. Occurrence of Helicobacter pylori in in saliva from preschool-age children[J]. Oral Sci Int,2015,12(1):5-8. doi: 10.1016/S1348-8643(14)00028-7
    [5]
    牛锦龙,贺波. 榆林地区儿童幽门螺杆菌感染流行病学调查分析[J]. 中国妇幼健康研究,2015,26,(4):666-668. doi: 10.3969/j.issn.1673-5293.2015.04.004
    [6]
    Figura N,Franceschi F,Santucci A,et aI. Extragastric manifestations of HeIicobacter pyIori infection[J]. HeIicobacter,2010,15(SuppI 1):60-68.
    [7]
    Fishbane Steven,Block Geoffey A,Loram Lisa,et al. Effects of ferric citrate in patients with nondialysis-dependent CKD and Iron deficiaicy anemia[J]. J Am Soc Nephrol,2017,28(6):1851-1858. doi: 10.1681/ASN.2016101053
    [8]
    张洋. 儿童青少年缺铁性贫血防治进展[J]. 中国处方药,2020,18(3):19-21. doi: 10.3969/j.issn.1671-945X.2020.03.011
    [9]
    YTN G,BIE S,GU H,et al. Application of gane chiptechnology in the diagnostic and dug resistance detection of Helicobacter pylori in children[J]. Journal of Gastroenterology and Hepatology,2020,35(8):1331-1339. doi: 10.1111/jgh.14980
    [10]
    赵张颖. 儿童幽门螺杆菌感染对全血锌、铁、钙、铜变化及对缺铁性贫血发生关系探讨[D]. 延安: 延安大学硕士学位论文, 2021.
    [11]
    Wang Xiangyu. A re-testing range is recommended for 13C- and 14C-urea breath tests for helicobacterpylori infection in China[J]. Gut Pathogens,2021,13(1):38. doi: 10.1186/s13099-021-00435-3
    [12]
    《中华儿科杂志》编辑委员会,中华医学会儿科学分会血液学组,中华医学会儿科学分会儿童保健学组. 儿童缺铁和缺铁性贫血防治建议[J]. 中华儿科杂志,2008,46(7):502-504. doi: 10.3321/j.issn:0578-1310.2008.07.006
    [13]
    张玉兰. 幽门螺杆菌感染与婴幼儿缺铁性贫血的临床研究[J]. 医学综述,2014,20(16):3046-3048. doi: 10.3969/j.issn.1006-2084.2014.16.068
    [14]
    卢俊会,陈星,马瑞军. 碳13尿素呼气试验定量值在胃相关疾病中的应用现状[J]. 中国实用医刊,2017,44(17):122-124. doi: 10.3760/cma.j.issn.1674-4756.2017.17.040
    [15]
    中华医学会儿科学分会消化学组,《中华儿科杂志》编辑委员会. 儿童幽门螺杆菌感染诊治专家共识[J]. 中华儿科杂志,2015,53(7):496-498. doi: 10.3760/cma.j.issn.0578-1310.2015.07.006
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