Advances on Scutellarin Anti-Oxidative Stress Mechanism in the Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases

Li DONG; Shibo SUN; Shuguang SUN

doi:10.12259/j.issn.2095-610X.S20220423

Volume 43 Issue 4

Apr. 2022

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Li DONG, Shibo SUN, Shuguang SUN. Advances on Scutellarin Anti-Oxidative Stress Mechanism in the Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases[J]. Journal of Kunming Medical University, 2022, 43(4): 146-151. doi: 10.12259/j.issn.2095-610X.S20220423

Citation:

Li DONG, Shibo SUN, Shuguang SUN. Advances on Scutellarin Anti-Oxidative Stress Mechanism in the Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases[J]. Journal of Kunming Medical University, 2022, 43(4): 146-151. doi: 10.12259/j.issn.2095-610X.S20220423

Citation:

Li DONG, Shibo SUN, Shuguang SUN. Advances on Scutellarin Anti-Oxidative Stress Mechanism in the Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases[J]. Journal of Kunming Medical University, 2022, 43(4): 146-151. doi: 10.12259/j.issn.2095-610X.S20220423

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Advances on Scutellarin Anti-Oxidative Stress Mechanism in the Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases

doi: 10.12259/j.issn.2095-610X.S20220423

Li DONG^{1, 2},
Shibo SUN³,
Shuguang SUN^{4
,
,}

1.
Clinical Medical College，Dali University，Dali Yunnan 671000
2.
Central Health Center of Chengzi Town，Longchuan County，Dehong Yunnan 678701
3.
Dept. of Respiratory and Critical Care Medicine，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
4.
Dept. of Endocrinology，The 1st Affiliated Hospital of Dali University，Dali Yunnan 671000，China

Received Date: 2022-02-14
Available Online: 2022-03-23
Publish Date: 2022-04-25

Abstract

Abstract

Scutellarin, chemically named 4, 5, 6-trihydroxyflavone-7-glucosidic acid, is the main active ingredient of the traditional Chinese medicine Breviscapus. Clinically, it has been used in the treatment of cardiovascular and cerebrovascular diseases because of its extremely wide biological activities. In recent years, cardiovascular and cerebrovascular diseases characterized by high morbidity and mortality have become common and frequently-occurring diseases among middle-aged and elderly people. With the change of people’ s diet, unhealthy life style, the onset of the disease has a trend of younger age. Studies have shown that oxidative stress is an extremely important factor in the occurrence and development of cardiovascular and cerebrovascular diseases. Scutellarin has a better therapeutic effect on the treatment of cardiovascular and cerebrovascular diseases. Therefore, it is not difficult to find that scutellarin has a certain inhibitory effect on oxidative stress. This article reviews the mechanism of scutellarin and oxidative stress, and to explore the clinical application of scutellarin to inhibit oxidative stress, so as to provide a certain evidence for the treatment of clinical diseases in the future.
- Scutellarin,
- Oxidative stress,
- Cardiovascular and cerebrovascular diseases

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References(51)

References

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