Advances on HBV Infection in the Occurrence and Development of Gynecologic Malignancies

Xiaojie CHEN; Xingrao WU; Shuhui YU; Zheng LI; Lan ZHANG

doi:10.12259/j.issn.2095-610X.S20220424

Volume 43 Issue 4

Apr. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(4): 152-157

Xiaojie CHEN, Xingrao WU, Shuhui YU, Zheng LI, Lan ZHANG. Advances on HBV Infection in the Occurrence and Development of Gynecologic Malignancies[J]. Journal of Kunming Medical University, 2022, 43(4): 152-157. doi: 10.12259/j.issn.2095-610X.S20220424

Citation:

Xiaojie CHEN, Xingrao WU, Shuhui YU, Zheng LI, Lan ZHANG. Advances on HBV Infection in the Occurrence and Development of Gynecologic Malignancies[J]. Journal of Kunming Medical University, 2022, 43(4): 152-157. doi: 10.12259/j.issn.2095-610X.S20220424

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Advances on HBV Infection in the Occurrence and Development of Gynecologic Malignancies

doi: 10.12259/j.issn.2095-610X.S20220424

1.
Dept. of Pharmacy，Yanshi Traditional Chinese Medicine Hospital，Luoyang Henan 471900
2.
Dept. of Radiotherapy，Yunnan Cancer Hospital，The 3rd Affiliated Hospital of Kunming Medical University
3.
Dept. of Gynecologic Oncology，Yunnan Cancer Hospital，The 3rd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650118，China

Received Date: 2022-02-23
Publish Date: 2022-04-25

Abstract

Abstract

The incidence of human cancers attributable to infectious agents has been estimated to be 15%. Hepatitis B virus（HBV） infects hepatocytes causing hepatocellular carcinoma. It can also infect extrahepatic cells and cause chronic inflammation, which is associated with a variety of extrahepatic cancers. Female reproductive organs communicate with the external environment through vagina. Viral nucleic acid can be detected in the vaginal secretions and ovarian tissues of HBV carriers. Epidemiological studies suggested HBV infection may be a risk factor for gynecologic malignancies, and related to poor prognosis of patients. Cervical cancer, endometrial cancer and ovarian cancer are most common gynecologic malignancies. This paper reviews the recent studies on the association between HBV infection and gynecologic malignancies, and analyzes the potential mechanism of HBV infection in the occurrence and development of cancer and prospects the future research direction.
- HBV,
- Gynecologic malignancies,
- Occurrence,
- Development

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References(42)

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