Effects of Subcutaneous Injection of Quick Acting Insulin Analogues at Different Time Points on Blood Glucose Level and MCP-1 Level in Patients with Hyperglycemic Crisis

Jie AN; Hui LIU; Shuohua CHEN

doi:10.12259/j.issn.2095-610X.S20220428

Volume 43 Issue 4

Apr. 2022

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Jie AN, Hui LIU, Shuohua CHEN. Effects of Subcutaneous Injection of Quick Acting Insulin Analogues at Different Time Points on Blood Glucose Level and MCP-1 Level in Patients with Hyperglycemic Crisis[J]. Journal of Kunming Medical University, 2022, 43(4): 142-145. doi: 10.12259/j.issn.2095-610X.S20220428

Citation:

Jie AN, Hui LIU, Shuohua CHEN. Effects of Subcutaneous Injection of Quick Acting Insulin Analogues at Different Time Points on Blood Glucose Level and MCP-1 Level in Patients with Hyperglycemic Crisis[J]. Journal of Kunming Medical University, 2022, 43(4): 142-145. doi: 10.12259/j.issn.2095-610X.S20220428

Citation:

Jie AN, Hui LIU, Shuohua CHEN. Effects of Subcutaneous Injection of Quick Acting Insulin Analogues at Different Time Points on Blood Glucose Level and MCP-1 Level in Patients with Hyperglycemic Crisis[J]. Journal of Kunming Medical University, 2022, 43(4): 142-145. doi: 10.12259/j.issn.2095-610X.S20220428

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Effects of Subcutaneous Injection of Quick Acting Insulin Analogues at Different Time Points on Blood Glucose Level and MCP-1 Level in Patients with Hyperglycemic Crisis

doi: 10.12259/j.issn.2095-610X.S20220428

Jie AN¹,
Hui LIU^{2
,
,},
Shuohua CHEN³

1.
Quality Control Office
2.
Dept. of Infectious Diseases
3.
Dept. of Cardiology，Kailuan General Hospital Affiliated to North China University of Science and Technology，Tangshan Hebei 063000，China

Received Date: 2022-02-17
Available Online: 2022-03-15
Publish Date: 2022-04-25

Abstract

Abstract

Objective To investigate the effects of subcutaneous injection of quick acting insulin analogues on blood glucose level and MCP-1 in patients with hyperglycemic crisis. Methods A total of 89 patients with hyperglycemia crisis in our hospital from March 2017 to November 2018 were randomly divided into observation group （n = 45, subcutaneous injection of insulin analogue after insulin injection with micropump stopped） and control group （n = 44, insulin analogues were administered subcutaneously 1 hour before the insulin micropump was discontinued）. The mean blood glucose values and blood glucose fluctuation amplitude of patients in the two groups were measured at 0.5 and 1 h before pump withdrawal and 0.5, 1 and 2 h after pump withdrawal. White blood cell index （WBC）, urine ketone body, monocyte chemochemic protein-1 （MCP-1）, insulin resistance index （HOMA-IR）, osmotic pressure and anionic gap were detected in 2 groups > 24 h, and the changes of patients status were analyzed. Results There was no significant difference in blood glucose fluctuation between 2 groups at 0.5 h before pump stop, 0.5, 1 and 2 h after pump stop （P > 0.05）. There were no differences in homA-IR, WBC, MCP-1, urine ketone body, osmotic pressure and anionic gap between 2 groups before and after insulin analogue injection at different time points for 24 h （P > 0.05）. Conclusion For patients with hyperglycemic crisis, the conversion of subcutaneous insulin injection can be carried out simultaneously when the intravenous pump injection of insulin is stopped, and there is no effect on the blood glucose fluctuation, HOMA-IR, MCP-1, urinary ketone body, WBC, osmotic pressure and anion gap indexes 24 hours before and after injection.
- Insulin analogues,
- Subcutaneous injection,
- Hyperglycemic crisis,
- Diabetes,
- MCP-1,
- HOMA-IR

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References(15)

References

[1]	Elangovan A,Cattamanchi S,Farook A R,et al. Validation of predicting hyperglycemic crisis death score:A risk stratification tool for appropriate disposition of hyperglycemic crisis patients from the emergency department[J]. J Emerg Trauma Shock,2018,11(2):104-110. doi: 10.4103/JETS.JETS_2_17
[2]	高华,金长梅,张楠. 糖尿病患者馒头餐胰岛素-C肽释放实验后血糖变化及影响因素分析[J]. 西南国防医药,2020,30(7):628-631. doi: 10.3969/j.issn.1004-0188.2020.07.009
[3]	孙维颖,楼滨城. 美国糖尿病学会对糖尿病高血糖危象的诊治指南(一)[J]. 世界急危重病医学杂志,2005,2(3):766-767.
[4]	You J H,Song S O,Park S H,et al. Trends in hyperglycemic crisis hospitalizations and in- and out-of-hospital mortality in the last decade based on korean national health insurance claims data[J]. Endocrinol Metab (Seoul),2019,34(3):275-281. doi: 10.3803/EnM.2019.34.3.275
[5]	中华医学会糖尿病学分会. 中国高血糖危象诊断与治疗指南[J]. 中华糖尿病杂志, 2013（8）:449-461.
[6]	陈曼丽,唐龙妹,齐莉莉,等. 胰岛素类似物与胰岛素抗体(IAA)相关性研究[J]. 河北医药,2020,42(5):5.
[7]	严金霞,尚治新,简黎. 规范化胰岛素注射对糖尿病患者血糖,血脂,血压水平的影响[J]. 国际护理学杂志,2021,40(8):1411-1413.
[8]	吴松. 胰岛素不同给药方式治疗急诊糖尿病酮症酸中毒的临床效果[J]. 临床医药文献电子杂志,2019,6(18):1.
[9]	王新月,霍森烨. 胰岛素(皮下注射)对妊娠期糖尿病患者血糖控制效果及妊娠结局的影响分析[J]. 医药界,2020,7(4):1-2.
[10]	赵英英. 胰岛素不同给药方式治疗糖尿病酮症酸中毒的疗效及对血糖水平的影响[J]. 临床医药文献电子杂志,2020,7(30):55.
[11]	郭玉佩. 不同方式注射胰岛素控制结肠癌合并糖尿病患者围手术期血糖的效果比较[J]. 中国肛肠病杂志,2020,40(11):53-55. doi: 10.3969/j.issn.1000-1174.2020.11.022
[12]	许琳. 胰素不同给药方式糖尿病足病高血糖状态的影响[J]. 糖尿病天地,2019,16(2):46.
[13]	So A,Sakaguchi K,Okada Y,et al. Relation between HOMA-IR and insulin sensitivity index determined by hyperinsulinemic-euglycemic clamp analysis during treatment with a sodium-glucose cotransporter 2 inhibitor[J]. Endocr J,2020,67(5):501-507. doi: 10.1507/endocrj.EJ19-0445
[14]	Bulboacă A E,Boarescu P M,Bolboacă S D,et al. Comparative effect of curcumin versus liposomal curcumin on systemic pro-inflammatory cytokines profile,MCP-1 and RANTES In experimental diabetes mellitus[J]. Int J Nanomedicine,2019,18(14):8961-8972.
[15]	周洪,江峰锦,徐荣,等. 血糖控制对高血糖危象患者外周血MCP-1水平的影响[J]. 中国老年学杂志,2014(10):2663-2665. doi: 10.3969/j.issn.1005-9202.2014.10.024

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