Application of Gene Detection for Individualized Medication for Hypertension in Patients with Grade 3 Hypertension

Liu LI; Yaru WANG; Di ZHANG; Qincong CHEN; Ming WANG; Shuo WANG

doi:10.12259/j.issn.2095-610X.S20220430

Volume 43 Issue 4

Apr. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(4): 112-117

Liu LI, Yaru WANG, Di ZHANG, Qincong CHEN, Ming WANG, Shuo WANG. Application of Gene Detection for Individualized Medication for Hypertension in Patients with Grade 3 Hypertension[J]. Journal of Kunming Medical University, 2022, 43(4): 112-117. doi: 10.12259/j.issn.2095-610X.S20220430

Citation:

Liu LI, Yaru WANG, Di ZHANG, Qincong CHEN, Ming WANG, Shuo WANG. Application of Gene Detection for Individualized Medication for Hypertension in Patients with Grade 3 Hypertension[J]. Journal of Kunming Medical University, 2022, 43(4): 112-117. doi: 10.12259/j.issn.2095-610X.S20220430

Citation:

Liu LI, Yaru WANG, Di ZHANG, Qincong CHEN, Ming WANG, Shuo WANG. Application of Gene Detection for Individualized Medication for Hypertension in Patients with Grade 3 Hypertension[J]. Journal of Kunming Medical University, 2022, 43(4): 112-117. doi: 10.12259/j.issn.2095-610X.S20220430

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Application of Gene Detection for Individualized Medication for Hypertension in Patients with Grade 3 Hypertension

doi: 10.12259/j.issn.2095-610X.S20220430

1.
Dept. of Cardiology，The 1st Hospital of Hebei Medical University，Shijiazhuang Hebei 050011
2.
Dept. of Cardiology，Shijiazhuang People’s Hospital， Shijiazhuang Hebei 050031，China

Received Date: 2022-03-04
Available Online: 2022-03-15
Publish Date: 2022-04-25

Abstract

Abstract

Objective To explore the effectiveness of gene detection in improving individualized medication’s curative effect in patients with hypertension. Methods 200 inpatients with grade 3 hypertension were randomly divided into two groups. There were 100 patients in the gene testing group. After admission, personalized drug genetic testing was performed for hypertension, and then individualized precise antihypertensive therapy was performed according to the results of gene testing. The other group was the rontine treatment group, a total of 100 patients, according to previous conventional treatment based on experience. The time of blood pressure compliance, side effects of antihypertensive drugs and hospital stay were recorded. Results The blood pressure compliance rate of patients within 4 d in hospital was 41% in gene testing group versus 17% in rontine treatment group, and the incidence of drug side effects was 13% in gene testing group versus 27% in rontine treatment group. Gene testing group was significantly better than rontine treatment group, with statistical significance （P < 0.05）. Average length of hospital stay in gene testing group （5.42±3.24） d vs rontine treatment group （6.26±3.43） d, gene testing group was significantly lower than rontine treatment group, the difference was statistically significant （P < 0.05）. Conclusion Gene detection of individualized medication for hypertension can improve the curative effect of patients with hypertension and shorten the average hospital stay of patients with hypertension.
- Hypertension,
- Gene detection,
- Average hospital stay

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References(28)

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