Application of Gene Detection for Individualized Medication for Hypertension in Patients with Grade 3 Hypertension

Liu LI; Yaru WANG; Di ZHANG; Qincong CHEN; Ming WANG; Shuo WANG

doi:10.12259/j.issn.2095-610X.S20220430

Volume 43 Issue 4

Apr. 2022

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2022 > 43(4): 112-117

Liu LI, Yaru WANG, Di ZHANG, Qincong CHEN, Ming WANG, Shuo WANG. Application of Gene Detection for Individualized Medication for Hypertension in Patients with Grade 3 Hypertension[J]. Journal of Kunming Medical University, 2022, 43(4): 112-117. doi: 10.12259/j.issn.2095-610X.S20220430

Citation:

Liu LI, Yaru WANG, Di ZHANG, Qincong CHEN, Ming WANG, Shuo WANG. Application of Gene Detection for Individualized Medication for Hypertension in Patients with Grade 3 Hypertension[J]. Journal of Kunming Medical University, 2022, 43(4): 112-117. doi: 10.12259/j.issn.2095-610X.S20220430

Citation:

Liu LI, Yaru WANG, Di ZHANG, Qincong CHEN, Ming WANG, Shuo WANG. Application of Gene Detection for Individualized Medication for Hypertension in Patients with Grade 3 Hypertension[J]. Journal of Kunming Medical University, 2022, 43(4): 112-117. doi: 10.12259/j.issn.2095-610X.S20220430

PDF( 651 KB)

Application of Gene Detection for Individualized Medication for Hypertension in Patients with Grade 3 Hypertension

doi: 10.12259/j.issn.2095-610X.S20220430

1.
Dept. of Cardiology，The 1st Hospital of Hebei Medical University，Shijiazhuang Hebei 050011
2.
Dept. of Cardiology，Shijiazhuang People’s Hospital， Shijiazhuang Hebei 050031，China

Received Date: 2022-03-04
Available Online: 2022-03-15
Publish Date: 2022-04-25

Abstract

Abstract

Objective To explore the effectiveness of gene detection in improving individualized medication’s curative effect in patients with hypertension. Methods 200 inpatients with grade 3 hypertension were randomly divided into two groups. There were 100 patients in the gene testing group. After admission, personalized drug genetic testing was performed for hypertension, and then individualized precise antihypertensive therapy was performed according to the results of gene testing. The other group was the rontine treatment group, a total of 100 patients, according to previous conventional treatment based on experience. The time of blood pressure compliance, side effects of antihypertensive drugs and hospital stay were recorded. Results The blood pressure compliance rate of patients within 4 d in hospital was 41% in gene testing group versus 17% in rontine treatment group, and the incidence of drug side effects was 13% in gene testing group versus 27% in rontine treatment group. Gene testing group was significantly better than rontine treatment group, with statistical significance （P < 0.05）. Average length of hospital stay in gene testing group （5.42±3.24） d vs rontine treatment group （6.26±3.43） d, gene testing group was significantly lower than rontine treatment group, the difference was statistically significant （P < 0.05）. Conclusion Gene detection of individualized medication for hypertension can improve the curative effect of patients with hypertension and shorten the average hospital stay of patients with hypertension.
- Hypertension,
- Gene detection,
- Average hospital stay

FullText(HTML)

References(28)

References

[1]	陈伟伟,高润霖,刘力生,等. 《中国心血管病报告 2016》概要[J]. 中国循环杂志,2017,32(6):521-531. doi: 10.3969/j.issn.1000-3614.2017.06.001
[2]	王耕,李立明,胡永华,等. 上海市社区人群高血压危险因素聚集与患病关系的研究[J]. 中华流行病学杂志,2013,34(4):307-310. doi: 10.3760/cma.j.issn.0254-6450.2013.04.001
[3]	Wang Z,Chen Z,Zhang L,et al. Status of hypertension in China:Results from the China hypertension survey,2012 - 2015[J]. Circulation,2018,137(22):2344-2356. doi: 10.1161/CIRCULATIONAHA.117.032380
[4]	Lewington S,Lacey B,Clarke R,et al. The burden of hypertension and associated risk for cardiovascular mortality in China[J]. JAMA Intern Med,2016,176(4):524-532. doi: 10.1001/jamainternmed.2016.0190
[5]	胡以松,姚崇华,王文志,等. 2002 年中国部分民族高血压患病情况[J]. 卫生研究,2006,35(5):573-575. doi: 10.3969/j.issn.1000-8020.2006.05.014
[6]	范国辉,王增武,张林峰,等. 2013 年北方四区县农村高血压患病率、知晓率、治疗率和控制率调查[J]. 中华医学杂志,2015,95(8):616-620. doi: 10.3760/cma.j.issn.0376-2491.2015.08.013
[7]	Yang L,Yan J,Tang X,et al. Prevalence,awareness,treatment,control and risk factors associated with hypertension among adults in southern China,2013[J]. PLoS One,2016,11(1):1-14. doi: 10.1371/journal.pone.0146181
[8]	国家卫生和计划生育委员会疾病预防控制局. 中国居民营养与慢性病状况报告（ 2015） [M]. 北京: 人民卫生出版社, 2015: 33 - 50.
[9]	冯宝玉,陈纪春,李莹,等. 中国成年人超重和肥胖与高血压发病关系的随访研究[J]. 中华流行病学杂志,2016,37(5):606-611. doi: 10.3760/cma.j.issn.0254-6450.2016.05.004
[10]	中华人民共和国国家卫生和计划生育委员会. 药物代谢酶和药物作用靶点基因检测技术指南（试行）概要[J/CD]. 实用器官移植电子杂志, 2015, 3（5）: 257-267.
[11]	Kato N,Takeuchi F,Tabara Y,et al. Meta_analysis of genome_wide association studies identifies common variants associated with blood pressure in east Asians[J]. Nat Genet,2011,43(6):531-538. doi: 10.1038/ng.834
[12]	Gao P J,Zhang K X,Zhu D L,et al. Diagnosis of liddle syndrome by genetic analysis of β and γ subunits of epithelial sodium channel_a report of five affected family members[J]. J Hypertens,2001,19(8):885-889.
[13]	Mulatero P,Morello F,Veglio F. Genetics of primary aldosteronism[J]. J Hy- Pertens,2004,22(11):663-670.
[14]	Ju S,Gao Y,Cao X,et al. Association between the lower extremity deep venous thrombosis,the warfarin maintenance dose,and CYP2C9* 3,CYP2D6* 10,and CYP3A5* 3 genetic polymorphisms:A case-control study[J]. Genet Test Mol Biomarkers,2017,21(9):539.
[15]	李露,李铭扬,王祥宇,等. ACE 基因插入/缺失多态性与中国原发性高血压患者 ACEI 降压效果及咳嗽风险关联性的 Meta 分析[J]. 临床心血管病杂志,2017,33(3):251-257.
[16]	柴光德, 范双莉, 苑长青 . 抗高血压药物基因多态性研究进展[C]//中国转化医学和整合医学研讨会论文综合刊, 2015.
[17]	周丽英,王宏伟,郝志敏. β1 受体 A145G 和 G1165C 多态性对比索洛尔治疗高血压疗效的影响[J]. 临床和实验医学杂志,2016,13(13):1285-1288.
[18]	张爱国. 心内科 5 类抗高血压药物的临床应用研究[J]. 中国社区医师,2018,34(4):90-93.
[19]	刘力生,孙宁玲,孙英贤,等. 中国高血压防治指南 2018 年修订版[J]. 心脑血管病防治,2019,2(19):8-9.
[20]	Dosh S A. The treatment of adults with essential hypertension( Ap- plied Evidence)[J]. J Fam Pract,2002,51(1):74-81.
[21]	乔崇. 南阳地区高血压人群药物基因组学与抗高血压基因导向个体化用药临床研究 [D]. 新乡: 新乡医学院硕士学位论文, 2014.
[22]	Ingelman-Sundberg M,Sim S C,Gomez A,et al. Influnce of cytochrome P450 polymrphisms on drug therapies:Pharmacogenetic,pharmacoepigenetic and clnical iaspects[J]. Pharmacol Ther,2007,116(3):469-526.
[23]	Bozina N,Bragamante V,Lovric M. Genetic polymorphism of metabolic enzymes P450(CYP) as a susceptibility factor for drug response. toxicity. and cancer risk[J]. Arh Hig Rada Toksikol,2009,60(2):217-242. doi: 10.2478/10004-1254-60-2009-1885
[24]	Breiner T,Man T,et al. Genetic polymorphisms of L-type calcium channel alphal C and alphal D subunit genes are associated with sensitivity to the antihypertensive effects of L-type dihydropyridine calcium -channel Mockers[J]. Cire J,2009,73(4):732-740. doi: 10.1253/circj.CJ-08-0761
[25]	李智,孙伟. 基因导向美托洛尔个体化治疗与常规治疗高血压的临床疗效、安全性及经济性评价[J]. 中国药物经济学,2017,12(08):27-29,33.
[26]	O'Toole L,Stewart M,Padfield P,et al. effect of the insertion/delection polymorphism of the angiotensin-converting enzyme gene on response to anglotensin-converting enzyme inhibitors in patients with heart failure[J]. Cardiovasc Phatmacol,1998,32(6):988-994. doi: 10.1097/00005344-199812000-00017
[27]	Sciarrone M T,Stella P,Barlassina C,et al. ACE and alplia-adducion polymorphism as markers of individual response to diuretic therapy[J]. Hypertension,2003,41(3):398-403. doi: 10.1161/01.HYP.0000057010.27011.2C
[28]	唐晓鸿,袁洪,李丽军,等. 血管紧张素转换酶基因I/D多态性与卡托普利疗效和咳嗽不良反应的关系及其可能机制[J]. 中国动脉硬化杂志,2008,16(5):242-243.

Relative Articles(20)

Relative Articles

[1]	Ru ZHANG, Yajing ZHAO, Wen ZHANG, Shunding TANG, Han WANG, Xiaoqing ZHANG. The Effects of Physical Activity Duration，Sleep Quality，and Weight Control on Patient-Reported Outcomes in Hypertensive Patients. Journal of Kunming Medical University, 2024, 46(): 1-8.
[2]	Huijuan ZENG, Bo TIAN, Hongling YUAN, Jie HE, Guanxi LI, Guojia RU, Min XU, Dong ZHAN. Predictive Modeling of Chronic Kidney Disease with Hypertension or Diabetes Based on Machine Learning Algorithms. Journal of Kunming Medical University, 2024, 45(3): 99-105. doi: 10.12259/j.issn.2095-610X.S20240315
[3]	Hualei DAI, Chengcheng HU, Guimin ZHANG, Siming TAO, Jiankun CHEN. Screening Biomarkers of Astragalus Membranaceus for Hypertensive Ventricular Remodeling Based on Network Pharmacology and Molecular Docking. Journal of Kunming Medical University, 2023, 44(8): 27-36. doi: 10.12259/j.issn.2095-610X.S20230819
[4]	Shunding TANG, Chonghua WAN, Ying SONG, Li DENG, Han WANG, Changwei SU, Xiaoqing ZHANG. Evaluation and Application of the Patients Reported Outcomes Measurement Scale for Hypertension. Journal of Kunming Medical University, 2022, 43(3): 60-66. doi: 10.12259/j.issn.2095-610X.S20220312
[5]	Lian-ju HE, Chun-mei ZUO, Lan LIU, Wen-long CUI, Jin-bo LI, Yi MO, Lu-ming FAN, Le CAI. Analysis of Trend in Prevalence of Hypertension and Its Relationship with Different Obesity Indices among Rural Adults in Fumin County of Yunnan Province. Journal of Kunming Medical University, 2021, 42(10): 38-44. doi: 10.12259/j.issn.2095-610X.S20211008
[6]	Xiu-qing WANG, Xin-tian LONG, Yong MAO, Jie CHEN, Jia ZHOU, Tian-shu CHU, Song-mei WANG, Cheng-huan SUN, Chun-mi LAI, Qian ZHANG. Prevalence and Determinants of Hypertension in Senior Nu Ethnic Group. Journal of Kunming Medical University, 2021, 42(9): 40-45. doi: 10.12259/j.issn.2095-610X.S20210922
[7]	Feng-ting MU, Chang-hong MU, Li-ping HE, Xiao-mei LI, Wen-jia ZHANG, Zhen YU, Qing-huan YANG, Hong-qin KE. Analysis of Hypertension and Its Influencing Factors in Dai and Jingpo Ethnic Groups in Dehong. Journal of Kunming Medical University, 2021, 42(8): 54-59. doi: 10.12259/j.issn.2095-610X.S20210810
[8]	Xin-tian LONG, Jie CHEN, Yong MAO, Xiu-qing WANG, Shuang-yan LU, Hui-jie PU, Jia ZHOU, Cheng-huan SUN, Song-mei WANG, Ai-fang YE. Detection Rate and Determinants of Hypertension among Seniors in Anning City. Journal of Kunming Medical University, 2021, 42(12): 11-16. doi: 10.12259/j.issn.2095-610X.S20211210
[9]	Zhang Li Qiong , Cai Le , Zhang Hong Qing , Cui Wen Long , Liu Ying Nan , Shen Jing Rong , He Lian Ju . . Journal of Kunming Medical University, 2020, 41(03): 30-34.
[10]	Xiao-qin LI, Min ZHOU, Lin WANG, Hai-yan ZENG, Peng-ju LUO, Li-jia LIN. Efficacy of PCR-reverse Dot Hybridization in Drug Resistance Gene Detection and Drug Sensitivity of BD960 Tuberculosis in Drug Resistance Tuberculosis Detection. Journal of Kunming Medical University, 2020, 41(12): 138-141. doi: 10.12259/j.issn.2095-610X.S20201238
[11]	Zhao Xiao Li , Yue Wei Wei , Miao Wen Qing , Qian Jing , Zhu Dan , Li Sui Wen , Yang Yue Lin , Li Hai Sheng , Hu Da Chun . . Journal of Kunming Medical University, 2020, 41(07): 76-79.
[12]	Dong Ling , Peng Yun Zhu , Huang Cheng , Huang Zhao , Chen Li Xing . Prevalence Rate and Associated Risk Factors of Hypertension in Bai Ethnic Group in Yunnan. Journal of Kunming Medical University, 2018, 39(07): 52-57.
[13]	Li Wen Hong . . Journal of Kunming Medical University,
[14]	Zhang Ti Ling . . Journal of Kunming Medical University,
[15]	Li Hong Fei . . Journal of Kunming Medical University,
[16]	Pang Xing Mei . . Journal of Kunming Medical University,
[17]	Zhang Li Gang . . Journal of Kunming Medical University,
[18]	Du Ying Rong . . Journal of Kunming Medical University,
[19]	Yang Zheng . . Journal of Kunming Medical University,
[20]	Chen Xue Qiang . . Journal of Kunming Medical University,