Predictive Value of RDW and Blood Lipid on Gastroesophageal Variceal Bleeding in Patients with Liver Cirrhosis

Qingqing WANG; Jie DING; Hongjie YANG; Guoji CHANG; Siqi LIU; Lijuan HUA; Yiying WANG; Shenghao LI

doi:10.12259/j.issn.2095-610X.S20220509

Volume 43 Issue 5

May 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(5): 144-148

Qingqing WANG, Jie DING, Hongjie YANG, Guoji CHANG, Siqi LIU, Lijuan HUA, Yiying WANG, Shenghao LI. Predictive Value of RDW and Blood Lipid on Gastroesophageal Variceal Bleeding in Patients with Liver Cirrhosis[J]. Journal of Kunming Medical University, 2022, 43(5): 144-148. doi: 10.12259/j.issn.2095-610X.S20220509

Citation:

Qingqing WANG, Jie DING, Hongjie YANG, Guoji CHANG, Siqi LIU, Lijuan HUA, Yiying WANG, Shenghao LI. Predictive Value of RDW and Blood Lipid on Gastroesophageal Variceal Bleeding in Patients with Liver Cirrhosis[J]. Journal of Kunming Medical University, 2022, 43(5): 144-148. doi: 10.12259/j.issn.2095-610X.S20220509

Citation:

Qingqing WANG, Jie DING, Hongjie YANG, Guoji CHANG, Siqi LIU, Lijuan HUA, Yiying WANG, Shenghao LI. Predictive Value of RDW and Blood Lipid on Gastroesophageal Variceal Bleeding in Patients with Liver Cirrhosis[J]. Journal of Kunming Medical University, 2022, 43(5): 144-148. doi: 10.12259/j.issn.2095-610X.S20220509

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Predictive Value of RDW and Blood Lipid on Gastroesophageal Variceal Bleeding in Patients with Liver Cirrhosis

doi: 10.12259/j.issn.2095-610X.S20220509

1.
Dept. of Hepatopathy
2.
Dept. of Science Education，The 3rd People’s Hospital of Kunming/Clinical-Medical Center of Infectious Disease of Yunnan Province；Kunming Yunnan 650041，China

Received Date: 2022-01-16
Available Online: 2022-05-06
Publish Date: 2022-05-27

Abstract

Abstract

Objective To explore the correlation between the red blood cell distribution width （RDW） / lipids and gastroesophageal variceal bleeding （GEVB） in patients with liver cirrhosis. Methods A total of 60 GEVB patients admitted to the Comprehensive Hepatology Department of the Third People’s Hospital of Kunming from January, 2021 to May, 2021 were assigned to the bleeding group, meanwhile, another 60 liver cirrhosis patients without GEVB were randomly selected as the non-bleeding group. The basic data, RDW, PLT, biochemical indexes of liver function and blood lipid related indexes of the two groups were compared, and then the effects of RDW and blood lipid on GEVB were explored through multivariate binary logistic regression analysis. Finally, ROC curves were used to assess the diagnostic effectiveness. Results Compared with the non-bleeding group, RDW in the bleeding group increased significantly, while TG, TC, HDL-C, LDL-C, ApoA1 and ApoE decreased significantly （all P < 0.05）. Binary logistic regression analysis showed that RDW was an independent risk factor （OR = 1.367, 95%CI: 1.141～1.639） while TC was the protective factor （OR = 0.437, 95%CI: 0.262～0.728） for GEVB in patients with liver cirrhosis （all P < 0.05）. For RDW, the area under curve （AUC） of ROC was 0.803 （P < 0.05）, optimum threshold was 15.25%, sensitivity and specificity were 86.7% and 63.3%, respectively; and for TC, AUC of ROC was 0.789 （P < 0.05）, optimum threshold was 2.765 mmol/L and the sensitivity and specificity were 78.3% and 75.0%, respectively. Conclusion RDW and TC have the high value in the diagnosis of GEVB in patients with liver cirrhosis, to which intensive attention should be paid clinically.
- Cirrhosis,
- Gastroesophageal variceal bleeding,
- Red cell distribution width,
- Blood lipid

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