Diagnostic Value of Gated Myocardial Perfusion Imaging Combined with NT-proBNP in Chronic Heart Failure

Feipeng WU; Xiandong ZHENG; Qiyan WU; Liju HONG; Lei YUE; Rui YANG; Dandan CHEN; Youjun ZHOU

doi:10.12259/j.issn.2095-610X.S20220511

Volume 43 Issue 5

May 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(5): 133-139

Feipeng WU, Xiandong ZHENG, Qiyan WU, Liju HONG, Lei YUE, Rui YANG, Dandan CHEN, Youjun ZHOU. Diagnostic Value of Gated Myocardial Perfusion Imaging Combined with NT-proBNP in Chronic Heart Failure[J]. Journal of Kunming Medical University, 2022, 43(5): 133-139. doi: 10.12259/j.issn.2095-610X.S20220511

Citation:

Feipeng WU, Xiandong ZHENG, Qiyan WU, Liju HONG, Lei YUE, Rui YANG, Dandan CHEN, Youjun ZHOU. Diagnostic Value of Gated Myocardial Perfusion Imaging Combined with NT-proBNP in Chronic Heart Failure[J]. Journal of Kunming Medical University, 2022, 43(5): 133-139. doi: 10.12259/j.issn.2095-610X.S20220511

Citation:

Feipeng WU, Xiandong ZHENG, Qiyan WU, Liju HONG, Lei YUE, Rui YANG, Dandan CHEN, Youjun ZHOU. Diagnostic Value of Gated Myocardial Perfusion Imaging Combined with NT-proBNP in Chronic Heart Failure[J]. Journal of Kunming Medical University, 2022, 43(5): 133-139. doi: 10.12259/j.issn.2095-610X.S20220511

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Diagnostic Value of Gated Myocardial Perfusion Imaging Combined with NT-proBNP in Chronic Heart Failure

doi: 10.12259/j.issn.2095-610X.S20220511

Dept. of Nuclear Medicine，Yan’an Hospital Affiliated to Kunming Medical University， Kunming Yunnan 650051，China

Received Date: 2022-01-11
Publish Date: 2022-05-25

Abstract

Abstract

Objectives To investigate the clinical value of gated myocardial perfusion imaging （GMPI）, high-sensitivity C-reactive protein （Hs-CRP） and N-terminal B-type natriuretic peptide （NT-proBNP） in the differential diagnosis of chronic heart failure. Methods Eighty one patients ultimately diagnosed with chronic heart failure by GMPI examination at Yanan Hospital Affiliated to Kunming Medical University between January 2020 and December 2021 were included as the heart failure group, sixty five subjects with a final diagnosis of non heart failure by GMPI examination during the same period were selected as the non heart failure group. After that, GMPI indicators: PHB, PSD, LVEF, LVEDV, LVESV, PFR and laboratory indicators: Hs-CRP, NT-proBNP were collected for all enrolled subjects so as to analyze the diagnostic efficacy of each parameter of GMPI, Hs-CRP and NT-proBNP indicators for chronic heart failure. Results All parameters of GMPI and AUC of NTpro-BNP in the diagnosis of chronic heart failure were > 0.800, P < 0.001; the AUC of Hs-CRP in the diagnosis of heart failure was 0.640, P < 0.05; the AUC of the combined scheme of LVEDV + LVESV + NTpro-BNP was 0.937, P < 0.001. Comparing AUC of different parameters: there was no significant difference between GMPI and NTpro-BNP （ P > 0.05）, all parameters of GMPI and AUC of NTpro-BNP were higher than Hs-CRP （ P < 0.05）, the AUC of the combined scheme of LVEDV + LVESV + NTpro-BNP was higher than that of GMPI, NTpro-BNP and Hs-CRP （ P < 0.05）. Conclusion The value of Hs-CRP alone in the differential diagnosis of chronic heart failure is limited; GMPI parameters are equivalent to the accuracy of traditional heart failure index NTpro-BNP in the diagnosis of heart failure and have the high diagnostic efficacy in the differentiation of the heart failure; GMPI combined with NTpro-BNP can achieve the higher diagnostic accuracy, which is worthy of further clinical application.
- Chronic heart failure,
- Gated myocardial perfusion imaging,
- Hypersensitivity C-Reactive Protein,
- Diagnostic tests

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References(20)

References

[1]	王华,梁延春. 中国心力衰竭诊断和治疗指南2018[J]. 中华心力衰竭和心肌病杂志,2018,46(4):196-197. doi: 10.3760/cma.j.issn.2096-3076.2018.12.002
[2]	Ponikowski P,Voors A A,Anker S D,et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure:The task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC[J]. Eur Heart J,2016,37(27):2129-2200. doi: 10.1093/eurheartj/ehw128
[3]	王华,李莹莹,柴坷,等. 中国住院心力衰竭患者流行病学及治疗现状[J]. 中华心血管病杂志,2019,47(11):865-874.
[4]	Charach G,Grosskopf I,Galin L,et al. Usefulness of cardiac biomarkers for prognosis of better outcomes in chronic heart failure:Retrospective 18-year follow-up study[J]. Medicine (Baltimore),2021,100(5):e23464.
[5]	中国医疗保健国际交流促进会循证医学分会,海峡两岸医药卫生交流协会老年医学专业委员会. 心力衰竭生物标志物中国专家共识[J]. 中华检验医学杂志,2020,43(2):130-141. doi: 10.3760/cma.j.issn.1009-9158.2020.02.007
[6]	中华医学会核医学分会,中华医学会心血管病学分会. 核素心肌显像临床应用指南(2018)[J]. 中华心血管病杂志,2019,47(7):519-527.
[7]	De Amorim Fernandes F,Peix A,Giubbini R,et al. Reproducibility of global LV function and dyssynchrony parameters derived from phase analysis of gated myocardial perfusion SPECT:A multicenter comparison with core laboratory setting[J]. Journal of Nuclear Cardiology,2020,27(5):1-10.
[8]	McDonagh T A,Metra M,Adamo M,et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure[J]. Eur Heart J,2021,42(36):3599-3726. doi: 10.1093/eurheartj/ehab368
[9]	Hung G U,Zou J,He Z,et al. Left-ventricular dyssynchrony in viable myocardium by myocardial perfusion SPECT is predictive of mechanical response to CRT[J]. Ann Nucl Med,2021,35(8):947-954. doi: 10.1007/s12149-021-01632-5
[10]	Chen J,Garcia E V,Bax J J,et al. SPECT myocardial perfusion imaging for the assessment of left ventricular mechanical dyssynchrony[J]. J Nucl Cardiol,2011,18(4):685-694. doi: 10.1007/s12350-011-9392-x
[11]	Fudim M,Dalgaard F,Fathallah M,et al. Mechanical dyssynchrony:How do we measure it,what it means,and what we can do about it[J]. Journal of Nuclear Cardiology,2019,28(5):2174-2184.
[12]	Van der Veen B J,Al Y I,Ajmone-Marsan N,et al. Ventricular dyssynchrony assessed by gated myocardial perfusion SPECT using a geometrical approach:A feasibility study[J]. Eur J Nucl Med Mol Imaging,2012,39(3):421-429. doi: 10.1007/s00259-011-1991-x
[13]	Hendriks T,Al A L,Maagdenberg C G,et al. Agreement of 2D transthoracic echocardiography with cardiovascular magnetic resonance imaging after ST-elevation myocardial infarction[J]. Eur J Radiol,2019,114(1):6-13.
[14]	Schofield R,Menezes L,Underwood S R. Nuclear cardiology:State of the art[J]. Heart,2021,107(12):954-961. doi: 10.1136/heartjnl-2019-315628
[15]	Jacobson A F,Narula J,Tijssen J. Analysis of differences in assessment of left ventricular function on echocardiography and nuclear perfusion imaging[J]. The American Journal of Cardiology,2021,156(1):85-92.
[16]	Pellikka P A,She L,Holly T A,et al. Variability in ejection fraction measured by echocardiography,gated single-photon emission computed tomography,and cardiac magnetic resonance in patients with coronary artery disease and left ventricular dysfunction[J]. JAMA Netw Open,2018,1(4):e181456. doi: 10.1001/jamanetworkopen.2018.1456
[17]	Matsuo H,Yoshimura Y,Fujita S,et al. Role of systemic inflammation in functional recovery,dysphagia,and 1-y mortality in heart failure:A prospective cohort study[J]. Nutrition,2021,91(11):111465.
[18]	Sheriff A,Kayser S,Brunner P,et al. C-reactive protein triggers cell death in ischemic cells[J]. Frontiers in immunology,2021,12(1):273.
[19]	Collado A,Domingo E,Piqueras L,et al. Primary hypercholesterolemia and development of cardiovascular disorders:Cellular and molecular mechanisms involved in low-grade systemic inflammation and endothelial dysfunction[J]. Int J Biochem Cell Biol,2021,139(10):106066.
[20]	芦珊,韩英,丁栗. 血清hs-CRP、cTnI、BNP及PCT联合检测对慢性心力衰竭的临床诊断价值[J]. 热带医学杂志,2021,21(2):193-196. doi: 10.3969/j.issn.1672-3619.2021.02.016

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