Expression Characteristics of Inflammatory Factors in the Serum of Patients with Adolescence Polycystic Ovary Syndrome

Xiaowei YUAN; Maohua QIN; Lijun WANG; Tingxian YANG; Jing JIN

doi:10.12259/j.issn.2095-610X.S20220517

Volume 43 Issue 5

May 2022

Turn off MathJax

Article Contents

Abstract

References

Relative Articles

Article Navigation > Journal of Kunming Medical University > 2022 > 43(5): 123-126

Xiaowei YUAN, Maohua QIN, Lijun WANG, Tingxian YANG, Jing JIN. Expression Characteristics of Inflammatory Factors in the Serum of Patients with Adolescence Polycystic Ovary Syndrome[J]. Journal of Kunming Medical University, 2022, 43(5): 123-126. doi: 10.12259/j.issn.2095-610X.S20220517

Citation:

Xiaowei YUAN, Maohua QIN, Lijun WANG, Tingxian YANG, Jing JIN. Expression Characteristics of Inflammatory Factors in the Serum of Patients with Adolescence Polycystic Ovary Syndrome[J]. Journal of Kunming Medical University, 2022, 43(5): 123-126. doi: 10.12259/j.issn.2095-610X.S20220517

Citation:

Xiaowei YUAN, Maohua QIN, Lijun WANG, Tingxian YANG, Jing JIN. Expression Characteristics of Inflammatory Factors in the Serum of Patients with Adolescence Polycystic Ovary Syndrome[J]. Journal of Kunming Medical University, 2022, 43(5): 123-126. doi: 10.12259/j.issn.2095-610X.S20220517

PDF( 567 KB)

Expression Characteristics of Inflammatory Factors in the Serum of Patients with Adolescence Polycystic Ovary Syndrome

doi: 10.12259/j.issn.2095-610X.S20220517

Dept. of Traditional Chinese Medicine，Kunming Maternal and Child Health Care Hospital， Kunming Yunnan 650031，China

Received Date: 2022-01-27
Available Online: 2022-05-12
Publish Date: 2022-05-27

Abstract

Abstract

Objective To study the expression of CRP, IL-6 and TNF-a in the serum of patients with the suspected adolescence polycystic ovary syndrome （PCOS）. Methods 80 patients with the suspected adolescence polycystic ovary syndrome （PCOS）were selected as the object of study （suspected adolescence PCOS group）, and 60 patients with adolescence PCOS were chosen as the PCOS group and60 normal adolescence women selected as the control group. The 80 subjects were divided into two subgroups: OA+PCOM group （40 cases） and OA+HA group （40 cases）. The levels of FSH, LH, T, E2, PRL, CRP, IL-6, TNF-a were detected. Results Serum levels of CRP、IL-6 in suspected adolescence PCOS group were significantly higher than those in the control group （P < 0.05）. Serum levels of CRP, TNF-a and IL-6 in OA+HA group were significantly higher than those in OA+PCOM group （P < 0.05）. Conclusion The high levels of IL-6 and CRP in patients with the suspected adolescence PCOS may help to identify the early puberty and provide the evidence for the early intervention of adolescence PCOS.
- Adolescence polycystic ovary syndrome,
- Inflammatory factors,
- Early intervention

FullText(HTML)

References(14)

References

[1]	Rostamtabar M,Esmaeilzadeh S,Karkhah A,et al. Elevated expression of IL-18 but not IL-1β gene is associated with NALP3 and AIM2 inflammasome in Polycystic Ovary Syndrome[J]. Gene,2020,731(10):144352.
[2]	中华医学会妇产科学分会内分泌学组及指南专家组、多囊卵巢综合征中国诊疗指南[J]. 中华妇产科杂志, 2018, 53（1）: 2-6.
[3]	Cirillo F,Catellani C,Lazzeroni P,et al. MiRNAs regulating insulin sensitivity are dysregulated in polycystic ovary syndrome (PCOS) ovaries and are associated with markers of inflammation and insulin sensitivity[J]. Front Endocrinol(Lausanne),2019,13(10):879.
[4]	苑晓微,刘国华,张雯,等. 3000例青春期门诊妇科疾病患者疾病特征的调查分析[J]. 中国性科学,2020,29(4):57-59.
[5]	Wang J,Zhu L,Hu K,et al. Effects of metformin treatment on serum levels of C-reactive protein and interleukin-6 in women with polycystic ovary syndrome:Ameta-analysis:APRISMA-compliantarticle[J]. Medicine(Baltimore),2017,96(39):e8183.
[6]	张静,孙子懿,刘聪,等. 多囊卵巢综合征患者炎性标志物的特点[J]. 医学综述,2019,25(3):540-543. doi: 10.3969/j.issn.1006-2084.2019.03.025
[7]	刘兰心、周承亮、杨倩,等. 炎症因子在多囊卵巢综合征中作用的研究进展[J]. 上海交通大学学报(医学版),2018,3(83):328-331.
[8]	Che X,Jian F,Chen C,et a1. PC0S serum-derived exosomal miR-27a-5p stimulates endometrial cancer cells migration and invasion[J]. J M0l Endocrinol,2020,64(1):1-12.
[9]	常艳艳,杨楠,苏雪梅,等. 多囊卵巢综合征患者炎症标志物表达水平与体质指数及胰岛素抵抗的关系[J]. 中国妇幼保健,2021,36(12):2818-2821.
[10]	童凤梅,李军. 超敏C反应蛋白在青春期多囊卵巢综合征肥胖患者血清中的表达水平及临床意义[J]. 中国医药导报,2014,16(5):755-758.
[11]	孙淼,张晓颖,李洋洋,等. 多囊卵巢综合征低度慢性炎症与肥胖的关系[J]. 河北医科大学学报,2021,42(7):823-826. doi: 10.3969/j.issn.1007-3205.2021.07.016
[12]	方亚. 多囊卵巢综合征患者胰岛素抵抗与慢性炎症反应的关系[J]. 河南医学研究,2020,29(27):5035-5037. doi: 10.3969/j.issn.1004-437X.2020.27.016
[13]	Mart í nez-Garc í a M,Moncayo S,Insenser M,et al. Post-prandial inflammatory responses after oral glucose,lipid and protein challenges:Influence of obesity,sex and polycystic ovary syndrome[J]. Clinical Nutrition,2020,39(3):876-885. doi: 10.1016/j.clnu.2019.03.027
[14]	屈海蓉,韩彩宁,张洪炜,等. IL-1β、IL-6、TNF-α及TGFβ1 基因多态性与多囊卵巢综合征风险的倾向性评分匹配分析[J]. 宁夏医学杂志,2021,43(9):773-776.

Relative Articles(20)

Relative Articles

[1]	Yamin WANG, Yuanyuan LI, Yanyun XUE. The Clinical Efficacy of Ginkgo Leaf Injection Combined with Donepezil in the Treatment of Alzheimer's Disease Based on Cerebral Hemodynamics and Inflammatory Factors. Journal of Kunming Medical University, 2024, 45(5): 157-163. doi: 10.12259/j.issn.2095-610X.S20240524
[2]	Wensong DING, Qicai QU, Hong LI, Liu YANG, Jianping TAO, Yongyu SI. Effects of Different Fluids on Microcirculation and Inflammatory Factors in Rabbits with Hemorrhagic Shock. Journal of Kunming Medical University, 2023, 44(12): 13-19. doi: 10.12259/j.issn.2095-610X.S20231202
[3]	Jiarong YUAN, Ying LIANG, Jian MA, Chao QI, Nan LI. Effect of Early Physical Instruction on Development of Preterm Infants. Journal of Kunming Medical University, 2022, 43(3): 103-107. doi: 10.12259/j.issn.2095-610X.S20220323
[4]	Xiaowei YUAN, Maohua QIN, Lijun WANG, Yuanqi DUAN. Expression of CRP，IL-6 and TNF-a in Serum of Patients with Adolescence Polycystic Ovary Syndrome. Journal of Kunming Medical University, 2022, 43(10): 136-138. doi: 10.12259/j.issn.2095-610X.S20221026
[5]	Zheng-jiang XING, Ya-xiong LI, Hong-lin ZOU, Zhen-kun YU, Wen-jun LI, Yun TANG, Zheng JIA. Effect of Regional Citric acid Anticoagulation on NLRP-3 and Downstream Inflammatory Factors Expression in Patients with AKI after Cardiopulmonary Bypass. Journal of Kunming Medical University, 2021, 42(12): 59-66. doi: 10.12259/j.issn.2095-610X.S20211221
[6]	Chen Yi . Clinical Study of Glucosidorum Tripterygll Totorum Combined with Prednisone Acetate and Hydroxychloroquine Sulfate in Treatment of Systemic Lupus Erythematosus. Journal of Kunming Medical University, 2018, 39(03): 98-102.
[7]	Ma Chen Li , Yang Gen Meng , Yan Qing Wen , Zhang Feng Yi , Shi Zhen Jin , Zhou Yi Qing , Wang Yi Hang , Zhao Yong Na , Zhang Dong Xian , Li Li Hua , Hong Shi Jun . Expression of Astrocyte, Neuron, and Proinflammatory Cytokines Derived from Frontal Cortex of Methamphetamine Dependent rats after Gastrodin Administration. Journal of Kunming Medical University, 2018, 39(06): 1-6.
[8]	Li Ya Ping , Li Yong Xia , Niu Xiao Qun , Hai Bing , Cao Yu , Chai Yan Ling . Correlation between Smoking and Inflammatory Factors in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Hypertension. Journal of Kunming Medical University, 2017, 38(06): 92-96.
[9]	Jiang Ting Ting . The Relationship Between Polycystic Ovary Syndrome and Vaspin，Apelin and Leptin. Journal of Kunming Medical University,
[10]	Zhang Li . Study on the Correlation Factors for Active Vitamin D3 Intervention for Elderly Patients with Sarcopenia in Plateau Regions. Journal of Kunming Medical University,
[11]	Yang Jian Zhi . Effects of Multimodal Analgesia on Cytokines and Cortisol Levels in Patients Received Surgical Treatment for Radical Colon Cancer. Journal of Kunming Medical University,
[12]	Su Hui Peng . . Journal of Kunming Medical University,
[13]	He Xiao Yu . . Journal of Kunming Medical University,
[14]	Shi Guo Qiang . . Journal of Kunming Medical University,
[15]	Qin Min Li . . Journal of Kunming Medical University,
[16]	Qin Min Li . . Journal of Kunming Medical University,
[17]	Xu Xia . . Journal of Kunming Medical University,
[18]	Ding Yan Jie . . Journal of Kunming Medical University,
[19]	Zou Zhi Rong . Flavonoid Isolated from the Leaves of Acer Truncatum Bunge Inhibits Lipopolysaccharide-induced Activation of Raw264.7 Cells. Journal of Kunming Medical University,
[20]	Chen Quan Dong . . Journal of Kunming Medical University,

Supplements(0)

Cited By

Cited by

Periodical cited type(3)

1.	李泉洋，吴国泰，王瑞琼. 中药黄酮类成分干预多囊卵巢综合征下丘脑-垂体-卵巢轴分泌紊乱的研究进展. 中华中医药学刊. 2025(02): 146-152 .
2.	危娟萍，钟柏林，危丽. 定坤丹与来曲唑治疗PCOS对患者超声指标及炎症因子影响. 中国医学创新. 2024(22): 133-137 .
3.	康星星，贺文艳. 多囊卵巢综合征患者外周血IL-1β、NGF、AMH和FSH的表达及其与不孕的相关性. 医学临床研究. 2023(12): 1980-1982 .