Advances in Research Progress on the Therapeutic Function of Biliverdin

Wenya BAI; Yuan YANG; Siying HUO; Xin YANG; Jianlin SHAO

doi:10.12259/j.issn.2095-610X.S20220601

Volume 43 Issue 6

Jun. 2022

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Wenya BAI, Yuan YANG, Siying HUO, Xin YANG, Jianlin SHAO. Advances in Research Progress on the Therapeutic Function of Biliverdin[J]. Journal of Kunming Medical University, 2022, 43(6): 147-153. doi: 10.12259/j.issn.2095-610X.S20220601

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Advances in Research Progress on the Therapeutic Function of Biliverdin

doi: 10.12259/j.issn.2095-610X.S20220601

Dept. of Anesthesiology，The 1st Affiliated Hospital of Kunming Medical University， Kunming Yunnan 650032，China

Received Date: 2022-03-13
Publish Date: 2022-06-25

Abstract

Abstract

Biliverdin and bilirubin are the products of heme metabolism. Many studies have found that biliverdin can continuously consume oxygen free radicals as well as activate biliverdin reductase, relying on the biliverdin-bilirubin redox recycling system. Biliverdin may play a crucial of antioxidant, anti-inflammatory, suppressing immune response, stabilizing vascular endothelial cells, regulating cell apoptosis and so on. In this review, we discussed the structure and metabolism of biliverdin/bilirubin, and mechanism of biliverdin therapeutic function in different diseases.
- Biliverdin,
- Biliverdin-bilirubin redox recycling system,
- Oxidative stress,
- Immune inflammation,
- Apoptosis

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References

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