A Preliminary Study of CASR/VDR/PTH1R Signaling Pathway in the Pathogenesis of Calcium-containing Kidney Stones

Jingling LI; Kunbin KE; Zhencheng WANG; Deqiang QIN; Hao LI

doi:10.12259/j.issn.2095-610X.S20220609

Volume 43 Issue 6

Jun. 2022

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Jingling LI, Kunbin KE, Zhencheng WANG, Deqiang QIN, Hao LI. A Preliminary Study of CASR/VDR/PTH1R Signaling Pathway in the Pathogenesis of Calcium-containing Kidney Stones[J]. Journal of Kunming Medical University, 2022, 43(6): 13-18. doi: 10.12259/j.issn.2095-610X.S20220609

Citation:

Jingling LI, Kunbin KE, Zhencheng WANG, Deqiang QIN, Hao LI. A Preliminary Study of CASR/VDR/PTH1R Signaling Pathway in the Pathogenesis of Calcium-containing Kidney Stones[J]. Journal of Kunming Medical University, 2022, 43(6): 13-18. doi: 10.12259/j.issn.2095-610X.S20220609

Citation:

Jingling LI, Kunbin KE, Zhencheng WANG, Deqiang QIN, Hao LI. A Preliminary Study of CASR/VDR/PTH1R Signaling Pathway in the Pathogenesis of Calcium-containing Kidney Stones[J]. Journal of Kunming Medical University, 2022, 43(6): 13-18. doi: 10.12259/j.issn.2095-610X.S20220609

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A Preliminary Study of CASR/VDR/PTH1R Signaling Pathway in the Pathogenesis of Calcium-containing Kidney Stones

doi: 10.12259/j.issn.2095-610X.S20220609

Dept. of Urinary Surgery，The First Affiliated Hospital of Kunming Medical University， Kunming Yunnan 650032，China

Received Date: 2022-03-08
Available Online: 2022-06-07
Publish Date: 2022-06-30

Abstract

Abstract

Objective To study the role and mechanism of CASR, VDR, PTH1R and other genes in the occurrence of calcium-containing kidney stones. Methods The renal medulla of patients with renal calculi was selected as the experimental group, and the normal renal medulla of patients with renal tumors was selected as the control group. The mRNA expression and protein level of CASR, VDR and PTH1R in renal solid tissue were detected by q-PCR, WB and immunofluorescence, respectively. Results There was no significant difference in the expression levels of CASR and PTH1R gene mRNA in the hydronephrotic medulla and the normal medulla of renal tumor （P > 0.05）. The difference of VDR gene mRNA expression in hydronephrotic medulla and normal medulla of renal tumor was statistically significant （P < 0.05）. Conclusion CASR, VDR, and PTH1R are involved in the occurrence of calcium-containing kidney stones, and may participate in the mechanism of calcium-containing kidney stones through the CASR/VDR/PTH1R signaling pathway.
- CASR,
- VDR,
- PTH1R,
- Gene expression,
- Kidney stones

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References(24)

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