Clinical Efficacy and Safety Evaluation of Fecal Bacteria Transplantation by Different Ways on Ulcerative Colitis

Xiaolin LIU; Xiaocui CHEN; Yang SUN; Minli LI; Yinglei MIAO

doi:10.12259/j.issn.2095-610X.S20220612

Volume 43 Issue 6

Jun. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(6): 46-51

Yang Jie . Effect of Slug and Sox9 on the Invasion and Metastasis of Nasopharyngeal Carcinoma Stem Cells[J]. Journal of Kunming Medical University, 2016, 37(01).

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Xiaolin LIU, Xiaocui CHEN, Yang SUN, Minli LI, Yinglei MIAO. Clinical Efficacy and Safety Evaluation of Fecal Bacteria Transplantation by Different Ways on Ulcerative Colitis[J]. Journal of Kunming Medical University, 2022, 43(6): 46-51. doi: 10.12259/j.issn.2095-610X.S20220612

Yang Jie . Effect of Slug and Sox9 on the Invasion and Metastasis of Nasopharyngeal Carcinoma Stem Cells[J]. Journal of Kunming Medical University, 2016, 37(01).

Citation:

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Clinical Efficacy and Safety Evaluation of Fecal Bacteria Transplantation by Different Ways on Ulcerative Colitis

doi: 10.12259/j.issn.2095-610X.S20220612

Yunnan Province Clinical Research Center for Digestive Disease/Dept. of Gastroenterology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2022-03-24
Publish Date: 2022-06-25

Abstract

Abstract

Objective To evaluate the efficacy and safety of upper and lower alimentary canal fecal bacteria transplantation in the treatment of ulcerative colitis, in order to guide clinical practice. Methods A total of 74 patients with mild to moderate active ulcerative colitis admitted to the Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University from October 2019 to September 2021 were selected, and they were randomly divided into two groups, including 2 cases of mid-course loss, 35 cases in the upper gastrointestinal tract pathway group and 37 cases in the lower gastrointestinal tract pathway group. Patients were evaluated with a modified Mayo Score. Results Mayo score of UC patients in both groups decreased after FMT treatment （P < 0.05）, and colonoscopy showed that mucosal inflammation, such as hyperemia, edema, erosion and ulcer, was improved compared with before treatment. There was no significant difference in Mayo Risk score between 2 groups before and after treatment （ P > 0.05）. Conclusion Fecal bacteria transplantation has a certain effect on the treatment of UC, and is safe and reliable. Fecal bacteria transplantation through upper gastrointestinal tract is as effective as that through lower gastrointestinal tract in the treatment of ulcerative colitis.
- Ulcerative colitis,
- Fecal bacteria transplantation,
- Transendoscopic enteral tubing,
- Clinical curative effect

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References

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