Evaluation of Drug Utilization in the Infected Patients with ESBLs Produced by Enterobacteriaceaein

Xueting YANG; Huifeng ZHANG

doi:10.12259/j.issn.2095-610X.S20220621

Volume 43 Issue 6

Jun. 2022

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Xueting YANG, Huifeng ZHANG. Evaluation of Drug Utilization in the Infected Patients with ESBLs Produced by Enterobacteriaceaein[J]. Journal of Kunming Medical University, 2022, 43(6): 74-78. doi: 10.12259/j.issn.2095-610X.S20220621

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Xueting YANG, Huifeng ZHANG. Evaluation of Drug Utilization in the Infected Patients with ESBLs Produced by Enterobacteriaceaein[J]. Journal of Kunming Medical University, 2022, 43(6): 74-78. doi: 10.12259/j.issn.2095-610X.S20220621

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Evaluation of Drug Utilization in the Infected Patients with ESBLs Produced by Enterobacteriaceaein

doi: 10.12259/j.issn.2095-610X.S20220621

Xueting YANG,
Huifeng ZHANG^,

Dept. of Pharmacy，The First People’s Hospital of Yunnan Province/The Affiliated Hospital of Kunming University of Science and Technology，Kunming Yunnan 650032，China

Received Date: 2022-03-18
Available Online: 2022-06-07
Publish Date: 2022-06-30

Abstract

Abstract

Objective To evaluate the rationality of antibiotics utilization in the infected patients with ESBLs produced by Enterobacteriaceaein one hospital． Methods The methods of drug utilization review（DUR） and drug utilization evaluation（DUE） were used to analyze the drug utilization, drug use index（DUI） , selection of antibacterials, medicine regimen and therapeutic outcome in 135 patients with ESBLs produced by Enterobacteriaceaein in the hospital from January 2017 to June 2017. Results The DUR method involved 16 kinds of antibiotics． Among them, 8 kinds were with DUI below 1, 5 kinds with DUI equal to 1, and 3 kinds with DUI above 1．The drugs with top five DDDs were cefmenoxime, cefoperazone sulbactam, levofloxacin and ceftriaxone. 100%; yet monitoring of PCT, liver function and adverse drug reactions had lower qualified rate. DUE criteria showed that qualified rate adverse drug reactions was 100%; yet the right antibiotics were selected for mild and moderate infection that it produced ESBLs risk factors（28.87%）, and the de-escalation treatmen was right（30%）. Conclusions A more comprehensive evaluation of drug utilization in patients with ESBLs produced by Enterobacteriaceaein can be achieved using DUR combined with DUE methods. The layering use of antibiotics and rational selection medicine regimen for the patients within the infected patients with ESBLs produced by Enterobacteriaceaein in the hospital still needs to be strengthened．
- ESBLs produced by Enterobacteriaceaein,
- Antibiotics,
- Drug utilization review,
- Drug utilization evaluation,
- Drug utilization index

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References(15)

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