Effects of Different Penetration Enhancers on in vitro Transdermal Permeation of Bagui Zhitong Cream

Jinli ZHANG; Jiahua MEI; Chengcheng LIAO; Dan HU; Hong HUANG; Yuanwen LI

doi:10.12259/j.issn.2095-610X.S20220623

Volume 43 Issue 6

Jun. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(6): 19-24

Jinli ZHANG, Jiahua MEI, Chengcheng LIAO, Dan HU, Hong HUANG, Yuanwen LI. Effects of Different Penetration Enhancers on in vitro Transdermal Permeation of Bagui Zhitong Cream[J]. Journal of Kunming Medical University, 2022, 43(6): 19-24. doi: 10.12259/j.issn.2095-610X.S20220623

Citation:

Jinli ZHANG, Jiahua MEI, Chengcheng LIAO, Dan HU, Hong HUANG, Yuanwen LI. Effects of Different Penetration Enhancers on in vitro Transdermal Permeation of Bagui Zhitong Cream[J]. Journal of Kunming Medical University, 2022, 43(6): 19-24. doi: 10.12259/j.issn.2095-610X.S20220623

Citation:

Jinli ZHANG, Jiahua MEI, Chengcheng LIAO, Dan HU, Hong HUANG, Yuanwen LI. Effects of Different Penetration Enhancers on in vitro Transdermal Permeation of Bagui Zhitong Cream[J]. Journal of Kunming Medical University, 2022, 43(6): 19-24. doi: 10.12259/j.issn.2095-610X.S20220623

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Effects of Different Penetration Enhancers on in vitro Transdermal Permeation of Bagui Zhitong Cream

doi: 10.12259/j.issn.2095-610X.S20220623

1.
Dept. of Dermatology，Lijiang County Hospital of Traditional Chinese Medicine，Lijiang Yunnan 674100
2.
College of Traditional Chinese Medicine，Yunnan Univerisity of Chinese Medicine，Kunming Yunnan 650500
3.
First School of Clinical Medicine of Yunnan Univerisity of Chinese Medicine，Kunming Yunnan 650021，China
4.
Dept. of Dermatology，Dongfang Hospital，Beijing University of Chinese Medicine，Beijing 10000，China

Received Date: 2022-02-08
Available Online: 2022-06-07
Publish Date: 2022-06-30

Abstract

Abstract

Objective To study the best preparation method of Bagui Zhitong cream, to determine the best matrix formulation, and to investigate the effect of different Penetration Enhancers on in vitro Transdermal Permeation of Bagui Zhitong Cream. Methods We prepared Bagui Zhitong Cream with different concentrations of penetration enhancer of azone. Modified Franz diffusion cell was adopted using mouse skin of isolated male rat as transdermal barrier. The content of Cinnamaldehyde was determined by UPLC. The accumulative transdermal amount （Q）and percutaneous permeability （J）were calculated and compared between different concentrations of BaGui Zhitong cream to select the best concentration of Penetration Enhancers. Results Different concentrations of azone promoted Cinnamaldehyde in vitro permeation in different degrees, the order of promoting infiltration was as follows: 5% azone > 3% azone > 7% azone > 1% azone > 10% azone. Through the multiple comparison, the difference had statistical significance （P < 0.05）. Conclusion In Bagui Zhitong cream containing 1% azone, 3% azone, 5% azone, 7% azone and 10% azone, 5% azone as penetration enhancer has the best effect in Bagui Zhitong Cream.
- Bagui Zhitong Cream,
- Penetration Enhancer,
- Extracorporeal Percutaneous Absorption,
- Cinnamaldehyde,
- Azone

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References(17)

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