Volume 43 Issue 6
Jun.  2022
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Article Navigation >  Journal of Kunming Medical University  > 2022  >  43(6): 154-158
Yuxin WEI, Shuwen LIANG, Chun CHEN, Xiuling LI, Shu ZHU, Fang YAN. Prediction of Delivery Mode by Transperineal Ultrasound during the Active Phase of the First Stage Labor[J]. Journal of Kunming Medical University, 2022, 43(9): 38-42. doi: 10.12259/j.issn.2095-610X.S20220908
Citation: Junjie SHU, Hongyu CHEN, Kai LIU, Puping LEI. Application of Whole-cell Patch Clamp Techniques in Inherited Long QT Syndrome and Sudden Unexplained Death[J]. Journal of Kunming Medical University, 2022, 43(6): 154-158. doi: 10.12259/j.issn.2095-610X.S20220629
shu

Application of Whole-cell Patch Clamp Techniques in Inherited Long QT Syndrome and Sudden Unexplained Death

doi: 10.12259/j.issn.2095-610X.S20220629
  • 1.

    Judicial Expertise Center of Kunming Medicial University，Kunming Yunnan 650500

  • 2.

    Dept. of Medical Imaging of Xinyang Central Hospital，Xinyang Henan 464000

  • 3.

    Henan Shengde Judicial Expertise Center，Xinyang Henan 464000

  • 4.

    Dept. of Forensic Medicine，Kunming Medical University，Kunming Yunnan 650500，China

  • Received Date: 2022-02-06
    Available Online: 2022-03-15
  • Publish Date: 2022-06-30
    Abstract
  • Cardiac channelopathy caused by genetic mutations have been recognized as a leading cause of sudden unexplained death （SUD）. Long QT syndrome is one of the most common cardiac channelopathies and its pathogenic genetic mutations have been continuously reported in various types of SUD. The functional verification of cardiac ion channel using whole-cell patch clamp techniques has important forensic significance for assessing of pathogenic of genetic mutations, identifying of cause of death of SUD and screening of risk population of SUD. This review summarizes the basic principles of whole-cell patch clamp techniques and its application in the study of pathogenesis of long QT syndrome and sudden unexplained death.
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    • References(19)
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