Expression and Clinical Significance of Eukaryotic Translation Initiation Factors 5A2 and Ki67 in Intrahepatic Cholangiocarcinoma

Gang LI; Shaohua YANG; Meng SHEN; Nan XIE; Guanbo ZHANG; Jiaxing WANG; Jinsong LI

doi:10.12259/j.issn.2095-610X.S20220630

Volume 43 Issue 6

Jun. 2022

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Gang LI, Shaohua YANG, Meng SHEN, Nan XIE, Guanbo ZHANG, Jiaxing WANG, Jinsong LI. Expression and Clinical Significance of Eukaryotic Translation Initiation Factors 5A2 and Ki67 in Intrahepatic Cholangiocarcinoma[J]. Journal of Kunming Medical University, 2022, 43(6): 7-12. doi: 10.12259/j.issn.2095-610X.S20220630

Citation:

Gang LI, Shaohua YANG, Meng SHEN, Nan XIE, Guanbo ZHANG, Jiaxing WANG, Jinsong LI. Expression and Clinical Significance of Eukaryotic Translation Initiation Factors 5A2 and Ki67 in Intrahepatic Cholangiocarcinoma[J]. Journal of Kunming Medical University, 2022, 43(6): 7-12. doi: 10.12259/j.issn.2095-610X.S20220630

Citation:

Gang LI, Shaohua YANG, Meng SHEN, Nan XIE, Guanbo ZHANG, Jiaxing WANG, Jinsong LI. Expression and Clinical Significance of Eukaryotic Translation Initiation Factors 5A2 and Ki67 in Intrahepatic Cholangiocarcinoma[J]. Journal of Kunming Medical University, 2022, 43(6): 7-12. doi: 10.12259/j.issn.2095-610X.S20220630

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Expression and Clinical Significance of Eukaryotic Translation Initiation Factors 5A2 and Ki67 in Intrahepatic Cholangiocarcinoma

doi: 10.12259/j.issn.2095-610X.S20220630

1.
Dept. of Hepatobiliary Surgery，Chengdu Seventh People’s Hospital，Chengdu Sichuan 610213
2.
Second Ward of Hepatobiliary and Pancreatic Surgery，Second Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101
3.
Dept. of Gastroenterology，The Second Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

Received Date: 2022-03-22
Available Online: 2022-06-30
Publish Date: 2022-06-30

Abstract

Abstract

Objective To analyze the clinical significance and correlation of eukaryotic translation initiation factor 5A2 （EIF5A2） and Ki67 expression in intrahepatic cholangiocarcinoma tissues. Methods Paraffin sections were collected from 118 patients with intrahepatic cholangiocarcinoma in the Department of Hepatobiliary Surgery of The Seventh People's Hospital of Chengdu and the Department of Hepatobiliary and Pancreatic Surgery of the Second Affiliated Hospital of Kunming Medical University from September 2014 to December 2021. Immunohistochemical methods were used to detect the expressions of EIF5A2 and Ki67, and clinicopathological data were collected. The positive expression of EIF5A2, Ki67 and different pathological features were analyzed. Results EIF5A2 was positively expressed in 60 cases （50.85%） and Ki67 was positively expressed in 81 cases （68.64%）. EIF5A2 expression was not related to age, sex, tumor diameter and tumor number （P > 0.05）, but related to TNM stage and lymphatic metastasis （P < 0.05）. The expression of Ki67 in intrahepatic cholangiocarcinoma tissues was not correlated with age, sex and tumor number （P > 0.05）, but with TNM stage, lymphatic metastasis and tumor diameter （P < 0.05）. EIF5A2 was positively correlated with the expression of Ki-67 （R = 0.285, P = 0.002）. Conclusion The expression of EIF5A2 and KI-67 in intrahepatic cholangiocarcinoma is positively correlated with high TNM stage and lymphatic metastasis, which is helpful to predict the clinical stage and prognosis of patients with intrahepatic cholangiocarcinoma.
- Intrahepatic cholangiocarcinoma,
- Eukaryotic translation initiation factor-5A2,
- Ki67,
- Immunohistochemical staining

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References(34)

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