Analysis of the Influence of Maternal Systemic Factors on Endometrial Implantation Window in Women with Repeated Implantation Failure

Yun BAI; Lanping ZHONG; Tingting ZHANG; Yuerong WU; Lei LI

doi:10.12259/j.issn.2095-610X.S20220701

Volume 43 Issue 7

Jul. 2022

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Yun BAI, Lanping ZHONG, Tingting ZHANG, Yuerong WU, Lei LI. Analysis of the Influence of Maternal Systemic Factors on Endometrial Implantation Window in Women with Repeated Implantation Failure[J]. Journal of Kunming Medical University, 2022, 43(7): 74-79. doi: 10.12259/j.issn.2095-610X.S20220701

Citation:

Yun BAI, Lanping ZHONG, Tingting ZHANG, Yuerong WU, Lei LI. Analysis of the Influence of Maternal Systemic Factors on Endometrial Implantation Window in Women with Repeated Implantation Failure[J]. Journal of Kunming Medical University, 2022, 43(7): 74-79. doi: 10.12259/j.issn.2095-610X.S20220701

Citation:

Yun BAI, Lanping ZHONG, Tingting ZHANG, Yuerong WU, Lei LI. Analysis of the Influence of Maternal Systemic Factors on Endometrial Implantation Window in Women with Repeated Implantation Failure[J]. Journal of Kunming Medical University, 2022, 43(7): 74-79. doi: 10.12259/j.issn.2095-610X.S20220701

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Analysis of the Influence of Maternal Systemic Factors on Endometrial Implantation Window in Women with Repeated Implantation Failure

doi: 10.12259/j.issn.2095-610X.S20220701

Dept. of Reproductive Medicine，The 1st People’s Hospital of Yunnan & The Affiliated Hospital of Kunming University of Science and Technology，Kunming Yunnan 650032，China

Received Date: 2022-03-28
Available Online: 2022-06-25
Publish Date: 2022-07-14

Abstract

Abstract

Objective To analyze the maternal and systemic factors that affect the endometrial implantation window in women with repeated implantation failure in assisted reproductive therapy. Methods Retrospective analysis was made on the data of cases diagnosed as repeated implantation failure and endometrial receptivity test （ERT） in the Department of Reproductive Medicine, First People's Hospital of Yunnan Province from December 2020 to January 2022. According to ERT results, they were divided into tolerance group and non-tolerance group. Insulin resistance, vitamin D deficiency, prethrombotic state, incidence of thyroid autoimmunity and positive rates of antinuclear antibody and antiphospholipid antibody were compared between the two groups. Logistic regression analysis was carried out on the results of the above single factor analysis, and the independent risk factors affecting the endometrial implant window were obtained. Results There was no significant difference in general information between the two groups （P > 0.05）, but there were significant differences in the incidence of insulin resistance and the positive rate of antiphospholipid antibody between the two groups （P < 0.05）. Multivariate logistic regression analysis showed that insulin resistance, prethrombotic state and thyroid autoimmunity were independent risk factors for endometrial implantation window （P < 0.05）. Conclusion Among the maternal factors, insulin resistance, prethrombotic state, and thyroid autoimmunity are the risk factors for the displacement of endometrial implant window in the population with repeated implant failure.
- Repeated implantation failure,
- Endometrial implantation window,
- Maternal factor,
- Systemic

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References(27)

References

[1]	Bergh Paul A and Navot Daniel. The impact of embryonic development and endometrial maturity on the timing of implantation[J]. Fertility and Sterility,1992,58(3):537-542. doi: 10.1016/S0015-0282(16)55259-5
[2]	He Aihua,Zou Yangyun,Wan Cheng,et al. The role of transcriptomic biomarkers of endometrial receptivity in personalized embryo transfer for patients with repeated implantation failure[J]. Journal of Translational Medicine,2021,19(1):176-189. doi: 10.1186/s12967-021-02837-y
[3]	黄荷凤,乔杰,刘嘉茵,等. 胚胎植入前遗传学诊断/筛查技术专家共识[J]. 中华医学遗传学杂志,2018,35(2):151-155.
[4]	Matthews D R,Hosker J P,Rudenski A S,et al. Homeostasis model assessment :insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man[J]. Diabetologia,1985,28:412-419.
[5]	Holick M F,Binkley N C,Bischoff-Ferrari H A,et al. Evaluation,treatment,and prevention of vitamin D deficiency:An Endocrine Society clinical practice guideline[J]. J Clin Endocrinol Metab,2011,96(7):1911-1930.
[6]	国家妇幼健康研究会生殖免疫学专业委员会专家共识编写组. 复发性流产合并血栓前状态诊治中国专家共识[J]. 中华生殖与避孕杂志,2021,41(10):861-875. doi: 10.3760/cma.j.cn101441-20210715-00310
[7]	Nardo L G,Li T C,Edwards R G. Introduction:human embryo implantation failure and recurrent miscarriage:basic science and clinical practice[J]. Reproductive Biomedicine Online,2006,13(1):11-12. doi: 10.1016/S1472-6483(10)62010-X
[8]	自然流产诊治中国专家共识编写组,赵爱民. 自然流产诊治中国专家共识(2020年版)[J]. 中国实用妇科与产科杂志,2020,36(11):1082-1090.
[9]	Sleigh A,Raymond-Barker P,Thackray K,et al. Mitochondrial dysfunction in patients with primary congenital insulin resistance[J]. Journal of Clinical Investigation,2011,121(6):2457-2461. doi: 10.1172/JCI46405
[10]	Kim J A,Wei Y,Sowers J R. Role of mitochondrial dysfunction in insulin resistance[J]. Circulation Research,2008,102(4):401-414. doi: 10.1161/CIRCRESAHA.107.165472
[11]	Xiang S,Xia M F,Song J Y,et al. Effect of electro-acupuncture on expression of IRS-1/PI3K/GLUT4 pathway in ovarian granulosa cells of infertile Patients with polycystic ovary syndrome-insulin resistance of phlegm-dampness syndrome[J]. Chinese Journal of Integrative Medicine,2021,27(5):330-335. doi: 10.1007/s11655-020-3219-z
[12]	Chang E M,Han J E,Seok H H,et al. Insulin resistance does not affect early embryo development but lowers implantation rate in in vitro maturation-in vitro fertilization-embryo transfer cycle[J]. Clinical Endocrinology,2013,79(1):93-99. doi: 10.1111/cen.12099
[13]	Dilek C,Belgin S,Taylor H S. Regulation of HOXA-10 expression by testosterone in vitro and in the endometrium of patients with polycystic ovary syndrome[J]. J Clin Endocrinol Metab,2003,88(1):238-243. doi: 10.1210/jc.2002-021072
[14]	Stefano P,Tiziana R,Angela F,et al. Decidual endovascular trophoblast invasion in women with polycystic ovary syndrome:an experimental case-control study.[J]. Obstetrical & Gynecological Survey,2012,67(7):2441-2449.
[15]	Giudice L C. Endometrium in PCOS:Implantation and predisposition to endocrine CA[J]. Best Practice & Research Clinical Endocrinology & Metabolism,2006,20(2):235-244.
[16]	Michael V W,Stefanie U,Uwe H,et al. Glucose Transporter Proteins (GLUT) in Human endometrium:Expression,regulation,and function throughout the menstrual cycle and in early pregnancy[J]. Journal of Clinical Endocrinology & Metabolism,2003(8):3885-3892.
[17]	齐家,孙赟,陈子江. 多囊卵巢综合征子宫内膜胰岛素抵抗的分子机制及生物学效应[J]. 中华生殖与避孕杂志,2018,38(6):513-516.
[18]	Wang Y,Lin X,Wu Q,et al. Thrombophilia markers in patients with recurrent early miscarriage[J]. Clinical Laboratory,2015,61(11):1787.
[19]	Bellver J,Soares S R,Alvarez C,et al. The role of thrombophilia and thyroid autoimmunity in unexplained infertility,implantation failure and recurrent spontaneous abortion[J]. Human Reproduction,2008,23(2):278-284.
[20]	邓伟,倪亚莉,杨杰,等. 遗传性易栓症与不明原因反复种植失败关系的系统评价[J]. 生殖医学杂志,2015,24(3):214-219.
[21]	Wen Yang,Ze Wu,Ming Yu,et al. Characteristics of midluteal phase uterine artery hemodynamics in patients with recurrent pregnancy loss[J]. The Journal of Obstetrics and Gynaecology Research,2019,45(7):1230-1235. doi: 10.1111/jog.13944
[22]	Yang W,Sun Q,Zhou Z,et al. Coagulation parameters predictive of repeated implantation failure in Chinese women:A retrospective study[J]. Medicine,2020,99(48):e23320. doi: 10.1097/MD.0000000000023320
[23]	Simopoulou M,Sfakianoudis K,Maziotis E,et al. The Impact of autoantibodies on IVF treatment and outcome:A systematic review[J]. International Journal of Molecular Sciences,2019,20(4):892-915. doi: 10.3390/ijms20040892
[24]	Leo S D,Pearce E N. Autoimmune thyroid disease during pregnancy[J]. Lancet Diabetes & Endocrinology,2018,6(7):575-586.
[25]	Monteleone P,Parrini D,Faviana P,et al. Female infertility related to thyroid autoimmunity:The ovarian follicle hypothesis[J]. American Journal of Reproductive Immunology,2011,66(2):108-114. doi: 10.1111/j.1600-0897.2010.00961.x
[26]	Andrea B,Alessio P,Luigi F,et al. The impact of thyroid autoimmunity on IVF/ICSI outcome:a systematic review and meta-analysis[J]. Human Reproduction Update,2016,22(6):793-794. doi: 10.1093/humupd/dmw034
[27]	Miko E , Meggyes M , Doba K , et al. Characteristics of peripheral blood NK and NKT-like cells in euthyroid and subclinical hypothyroid women with thyroid autoimmunity experiencing reproductive failure. [J]. Journal of Reproductive Immunology, 2017, 124期号: 62-70. Miko E,Meggyes M,Doba K,et al. Characteristics of peripheral blood NK and NKT-like cells in euthyroid and subclinical hypothyroid women with thyroid autoimmunity experiencing reproductive failure[J]. Journal of Reproductive Immunology,2017,124:62-70.

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