Analysis of the Influence of Maternal Systemic Factors on Endometrial Implantation Window in Women with Repeated Implantation Failure

Yun BAI; Lanping ZHONG; Tingting ZHANG; Yuerong WU; Lei LI

doi:10.12259/j.issn.2095-610X.S20220701

Volume 43 Issue 7

Jul. 2022

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Yun BAI, Lanping ZHONG, Tingting ZHANG, Yuerong WU, Lei LI. Analysis of the Influence of Maternal Systemic Factors on Endometrial Implantation Window in Women with Repeated Implantation Failure[J]. Journal of Kunming Medical University, 2022, 43(7): 74-79. doi: 10.12259/j.issn.2095-610X.S20220701

Citation:

Yun BAI, Lanping ZHONG, Tingting ZHANG, Yuerong WU, Lei LI. Analysis of the Influence of Maternal Systemic Factors on Endometrial Implantation Window in Women with Repeated Implantation Failure[J]. Journal of Kunming Medical University, 2022, 43(7): 74-79. doi: 10.12259/j.issn.2095-610X.S20220701

Citation:

Yun BAI, Lanping ZHONG, Tingting ZHANG, Yuerong WU, Lei LI. Analysis of the Influence of Maternal Systemic Factors on Endometrial Implantation Window in Women with Repeated Implantation Failure[J]. Journal of Kunming Medical University, 2022, 43(7): 74-79. doi: 10.12259/j.issn.2095-610X.S20220701

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Analysis of the Influence of Maternal Systemic Factors on Endometrial Implantation Window in Women with Repeated Implantation Failure

doi: 10.12259/j.issn.2095-610X.S20220701

Dept. of Reproductive Medicine，The 1st People’s Hospital of Yunnan & The Affiliated Hospital of Kunming University of Science and Technology，Kunming Yunnan 650032，China

Received Date: 2022-03-28
Available Online: 2022-06-25
Publish Date: 2022-07-14

Abstract

Abstract

Objective To analyze the maternal and systemic factors that affect the endometrial implantation window in women with repeated implantation failure in assisted reproductive therapy. Methods Retrospective analysis was made on the data of cases diagnosed as repeated implantation failure and endometrial receptivity test （ERT） in the Department of Reproductive Medicine, First People's Hospital of Yunnan Province from December 2020 to January 2022. According to ERT results, they were divided into tolerance group and non-tolerance group. Insulin resistance, vitamin D deficiency, prethrombotic state, incidence of thyroid autoimmunity and positive rates of antinuclear antibody and antiphospholipid antibody were compared between the two groups. Logistic regression analysis was carried out on the results of the above single factor analysis, and the independent risk factors affecting the endometrial implant window were obtained. Results There was no significant difference in general information between the two groups （P > 0.05）, but there were significant differences in the incidence of insulin resistance and the positive rate of antiphospholipid antibody between the two groups （P < 0.05）. Multivariate logistic regression analysis showed that insulin resistance, prethrombotic state and thyroid autoimmunity were independent risk factors for endometrial implantation window （P < 0.05）. Conclusion Among the maternal factors, insulin resistance, prethrombotic state, and thyroid autoimmunity are the risk factors for the displacement of endometrial implant window in the population with repeated implant failure.
- Repeated implantation failure,
- Endometrial implantation window,
- Maternal factor,
- Systemic

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References(27)

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