Clinical Analysis of Cervical Lymph Node Metastatic Squamous Cell Carcinoma of Unknown Primary Site

Shizhou LI; Xiaoguang HE; Yan LIN; Yuxiao LI; Xi YANG; Xiaoyu WANG; Shenghao YANG

doi:10.12259/j.issn.2095-610X.S20220710

Volume 43 Issue 7

Jul. 2022

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2022 > 43(7): 80-85

Shizhou LI, Xiaoguang HE, Yan LIN, Yuxiao LI, Xi YANG, Xiaoyu WANG, Shenghao YANG. Clinical Analysis of Cervical Lymph Node Metastatic Squamous Cell Carcinoma of Unknown Primary Site[J]. Journal of Kunming Medical University, 2022, 43(7): 80-85. doi: 10.12259/j.issn.2095-610X.S20220710

Citation:

Shizhou LI, Xiaoguang HE, Yan LIN, Yuxiao LI, Xi YANG, Xiaoyu WANG, Shenghao YANG. Clinical Analysis of Cervical Lymph Node Metastatic Squamous Cell Carcinoma of Unknown Primary Site[J]. Journal of Kunming Medical University, 2022, 43(7): 80-85. doi: 10.12259/j.issn.2095-610X.S20220710

Citation:

Shizhou LI, Xiaoguang HE, Yan LIN, Yuxiao LI, Xi YANG, Xiaoyu WANG, Shenghao YANG. Clinical Analysis of Cervical Lymph Node Metastatic Squamous Cell Carcinoma of Unknown Primary Site[J]. Journal of Kunming Medical University, 2022, 43(7): 80-85. doi: 10.12259/j.issn.2095-610X.S20220710

PDF( 1085 KB)

Clinical Analysis of Cervical Lymph Node Metastatic Squamous Cell Carcinoma of Unknown Primary Site

doi: 10.12259/j.issn.2095-610X.S20220710

Head and Neck Surgery，Second Department of Otolaryngology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2022-04-15
Available Online: 2022-06-25
Publish Date: 2022-07-14

Abstract

Abstract

Objective To analyze the clinical characteristics of squamous cell carcinoma with cervical lymph node metastasis of unknown primary （CCUP） focus, explore the prognostic factors, and provide the basis for clinical diagnosis and treatment. Methods The clinical data of 23 patients with CCUP who were admitted to our hospital from September 2018 to December 2020 were reviewed. Lymph node metastasis area, tumor stage, P16+, etc. were used as analysis indicators. Univariate analysis was used to establish Cox risk model to analyze prognostic factors. Results As of the end of follow-up, 19 patients survived and 4 died. There was no correlation between the survival prognosis of patients and the gender, course of disease, history of smoking and alcohol, EBV+, lymph node metastasis area, P16+, and whether the primary tumor was clear, and the difference was not statistically significant （all P > 0.05）, but it was related to the age of the patient. Correlation （P = 0.024 < 0.05）. In the N stage, the later the N stage, the lower the survival rate. The survival rate of patients with unknown primary tumor was lower and clinically significant, but the difference was not statistically significant. Conclusion The patients with CCUP have a short course of disease, and the level Ⅱ, Ⅲ neck lymph nodes are the most involved. EBV detection, P16 and other immunohistochemical staining are helpful for finding the primary site. The best diagnosis and treatment plan should be selected according to the patient’s condition to reduce tumor recurrence and improve the quality of life.
- Unknown primary tumor,
- Neck metastases,
- Squamous cell carcinoma,
- Prognosis

FullText(HTML)

References(16)

References

[1]	Civantos F J,Vermorken J B,Shah J P,et al. Metastatic squamous cell carcinoma to the cervical lymph nodes from an unknown primary cancer:Management in the HPV era[J]. Front Oncol,2020,10:593164. doi: 10.3389/fonc.2020.593164
[2]	Ye W,Arnaud E H,Langerman A,et al. Diagnostic approaches to carcinoma of unknown primary of the head and neck[J]. Eur J Cancer Care (Engl),2021,30(6):e13459.
[3]	Ebisumoto K,Sakai A,Maki D,et al. Tumor detection with transoral use of flexible endoscopy for unknown primary head and neck cancer[J]. Laryngoscope Investig Otolaryngol,2021,6(5):1037-1043. doi: 10.1002/lio2.656
[4]	Kennel T,Garrel R,Costes V,et al. Head and neck carcinoma of unknown primary[J]. Eur Ann Otorhinolaryngol Head Neck Dis,2019,136(3):185-192. doi: 10.1016/j.anorl.2019.04.002
[5]	Golusinski P,Di Maio P,Pehlivan B,et al. Evidence for the approach to the diagnostic evaluation of squamous cell carcinoma occult primary tumors of the head and neck[J]. Oral Oncol,2019,88:145-152. doi: 10.1016/j.oraloncology.2018.11.020
[6]	Kawamoto Y,Ikezawa K,Hasegawa S,et al. Ampullary cancer detected upon re-examination in a patient initially diagnosed as cancer of unknown primary[J]. JGH Open,2022,6(3):222-224. doi: 10.1002/jgh3.12710
[7]	Park K S,Lim H R,Jeong S H,et al. Treatment outcomes of patients with head and neck squamous cell carcinoma of unknown primary[J]. Chonnam Med J,2021,57(1):58-61. doi: 10.4068/cmj.2021.57.1.58
[8]	Li R,Liao K,Wei Z,et al. The prognostic role of radiotherapy and radiotherapy target in cervical lymph node metastatic squamous cell carcinoma with unknown primary:a retrospective study[J]. J Cancer Res Clin Oncol,2022,148(6):1437-1445. doi: 10.1007/s00432-021-03724-1
[9]	Qaseem A,Usman N,Jayaraj J S,et al. Cancer of unknown primary:A review on clinical guidelines in the development and targeted management of patients with the unknown primary site[J]. Cureus,2019,11(9):e5552.
[10]	Barbosa M,Duarte H,Breda E,et al. PET/CT in the management of metastatic cervical lymphadenopathy from unknown primary site:a seven years retrospective study[J]. Rev Laryngol Otol Rhinol (Bord),2013,134(2):89-94.
[11]	Szymonowicz K A,Chen J. Biological and clinical aspects of HPV-related cancers[J]. Cancer Biol Med,2020,17(4):864-878. doi: 10.20892/j.issn.2095-3941.2020.0370
[12]	Jalaly J B,Hosseini S M,Shafique K,et al. Current status of p16 immunohistochemistry and HPV testing in fine needle aspiration specimens of the head and neck[J]. Acta Cytol,2020,64(1-2):30-39. doi: 10.1159/000496158
[13]	Shahoumi L A,Yeudall W A. Targeted therapies for non-HPV-related head and neck cancer:challenges and opportunities in the context of predictive,preventive,and personalized medicine[J]. EPMA J,2019,10(3):291-305. doi: 10.1007/s13167-019-00177-y
[14]	Tsao S W,Tsang C M,Lo K W. Epstein-Barr virus infection and nasopharyngeal carcinoma[J]. Philos Trans R Soc Lond B Biol Sci,2017,372(1732):20160270.
[15]	Sprave T,Ruhle A,Hees K,et al. Radiotherapeutic management of cervical lymph node metastases from an unknown primary site - experiences from a large cohort treated with modern radiation techniques[J]. Radiat Oncol,2020,15(1):80. doi: 10.1186/s13014-020-01529-z
[16]	Wang Y,He S S,Bao Y,et al. Cervical lymph node carcinoma metastasis from unknown primary site:a retrospective analysis of 154 patients[J]. Cancer Med,2018,7(5):1852-1859. doi: 10.1002/cam4.1458

Relative Articles(20)

Relative Articles

[1]	Xinyi MEN, Jing ZHAO, Yongchun SHEN, Hui JI, Xiuxia WANG. The Relationship between Peripheral Blood Immunoglobulin，Erythrocyte Sedimentation Rate，Homocysteine and the Degree of Central Nervous System Vasculitis in Children and Their Influence on Prognosis. Journal of Kunming Medical University, 2024, 45(12): 1-7.
[2]	Ying ZHANG, Xiangru LUO, Xing WANG, Pan ZHAO, Kun LIAN, Yuanqin LI, Mingkun SHAO. Analysis on the Expression of Basement Membrane Protein in Endometrial Carcinoma and its Relationship with Immune Invasion. Journal of Kunming Medical University, 2024, 46(): 1-10.
[3]	Ruiting ZHANG, Bin YAN, Zuyan LI, Jinmin SUN, Jin YAO. Relations between Peripheral Blood Blast Clearance Time and Albumin Level at Initial Diagnosis during Induction Chemotherapy and Genetic Mutations and Prognosis in Patients with Acute Myeloid Leukemia. Journal of Kunming Medical University, 2024, 45(8): 117-124. doi: 10.12259/j.issn.2095-610X.S20240817
[4]	Chunyan LIU, Bingqing CHANG, Chao LI, Xin REN, Xiaoqin LIU. The Relationship between T Lymphocyte Subsets and Pathological Characteristics of Acute Myeloid Leukemia and the Value of Predicting Chemotherapy Prognosis. Journal of Kunming Medical University, 2024, 45(5): 116-122. doi: 10.12259/j.issn.2095-610X.S20240518
[5]	Qi NIE, Li LIU, Yue TIAN, Xiaoyan MAO, Qulian GUO, Xin TIAN. Abnormal Clinical Features and Prognosis of ACTH in Pediatric Acute B Lymphocytic Leukemia. Journal of Kunming Medical University, 2024, 45(10): 75-84. doi: 10.12259/j.issn.2095-610X.S20241012
[6]	Lizhu ZHAO, Ying DONG, Yue DENG, Lihua YANG. Correlation between Epithelial Cell Related Genes and Prognosis of Patients with Ovarian Cancer based on Single Cell Sequencing. Journal of Kunming Medical University, 2024, 45(4): 9-16. doi: 10.12259/j.issn.2095-610X.S20240402
[7]	Xiaohua LU, Hongxin YUAN. The Analysis of the Correlation between BTLA，CTLA-4 Gene Polymorphisms and the Efficacy and Prognosis of TACE Combined Targeted Therapy for Liver Cancer. Journal of Kunming Medical University, 2023, 44(9): 126-135. doi: 10.12259/j.issn.2095-610X.S20230927
[8]	Jiefu TANG, Dexing YANG, Shengzhe LIU, Qiang WANG, Kai FU, Zhenfang WANG, Ying LUAN, Min LI, Rong LIU. A Study on Prognostic Value of Cellular Immunological Indicators in Omicron Variant Infected Elderly Severe Patients. Journal of Kunming Medical University, 2023, 44(12): 87-94. doi: 10.12259/j.issn.2095-610X.S20231214
[9]	Jiadai TANG, Jing YANG, Hongli SONG, Jiaojiao CHEN, Zhonghui MIAO, Lin XIE. Correlation of Metastatic and Prognostic Factors in 318 Cases of Primary Gastric Cancer. Journal of Kunming Medical University, 2023, 44(2): 75-87. doi: 10.12259/j.issn.2095-610X.S20230218
[10]	Yaping JIANG, Hongying YANG, Haohan WANG, Xianling Ning, Xielan YANG. Effect of Different Intestinal Surgical Methods on Prognosis of Patients with Intestinal Invasive Epithelial Ovarian Cancer. Journal of Kunming Medical University, 2023, 44(1): 85-90. doi: 10.12259/j.issn.2095-610X.S20230109
[11]	Yao ZOU, Ziyu WANG, Jiao LI, Xingxin LI, Yaqiong SHEN, Jing XU, Yan JIN. Association between LOXL2 and Snail Expression Levels and Overall Survival Rate after Surgery in Patients with Cholangiocarcinoma. Journal of Kunming Medical University, 2022, 43(12): 81-87. doi: 10.12259/j.issn.2095-610X.S20221215
[12]	Honglan CHEN, Yi WU, Tao HU, Yuming WANG. Potential Value of G6PD Activity Detection in the Peripheral Blood for the Diagnosis and Prognosis of Cervical Cancer Patients with High Risk Human Papillomavirus Infection. Journal of Kunming Medical University, 2022, 43(2): 89-95. doi: 10.12259/j.issn.2095-610X.S20220203
[13]	En-zi FENG, Deng-huan WANG, Ran ZHANG, Xing-yu YANG, Nan ZHANG, Jie YANG, Xi-fang WU. Clinical Significance of HPV in Oropharyngeal Squamous Cell Carcinoma. Journal of Kunming Medical University, 2021, 42(11): 51-56. doi: 10.12259/j.issn.2095-610X.S20211109
[14]	Liu-zheng LI, Shun LU, Shi-rong ZHANG, Lei-sheng XU, Hai-rong ZHAO, Jia-wei FENG, Xue-chan GAO, Tong WU. Curative Effect of Combined Hemihepatectomy and Perihilar Hepatectomy in Treatment of Hilar Cholangiocarcinoma. Journal of Kunming Medical University, 2021, 42(10): 121-126. doi: 10.12259/j.issn.2095-610X.S20211014
[15]	Gang LI, Jin-song LI, Nan XIE, Chun-mang LI, Lei WEI, Fan CAO, Ying-zhen SU. Expression of B7-H4 in Intrahepatic Cholangiocarcinoma and Its Clinical Significance. Journal of Kunming Medical University, 2021, 42(4): 78-83. doi: 10.12259/j.issn.2095-610X.S20210415
[16]	Xu Yong Qin , Mei Xue , Luo Ru Qiong , Li Wei , Zhang Hai , Zhang Fang Fang . . Journal of Kunming Medical University, 2019, 40(08): 42-46.
[17]	Tan Hua , Ren Hong , Zhao Ling , You Ding Yun , Yang Ya Chen . Prognostic Factors of Patients with Primary Hepatocellular Carcinoma Treated with TACE. Journal of Kunming Medical University, 2019, 40(03): 29-34.
[18]	Mei Li Jun , Zhang Ning , Chen Wei . The Effect of Allogenic Blood Transfusion on the Prognosis after Esophagectomy among Patients with Esophageal Cancer. Journal of Kunming Medical University, 2018, 39(04): 73-78.
[19]	Nie Bo . Clinical Characteristic of 34 Patients with Extranodal Nasal Type NK/T-Cell Lymphoma. Journal of Kunming Medical University,
[20]	Yang Jie . . Journal of Kunming Medical University,