Clinical Analysis of Cervical Lymph Node Metastatic Squamous Cell Carcinoma of Unknown Primary Site

Shizhou LI; Xiaoguang HE; Yan LIN; Yuxiao LI; Xi YANG; Xiaoyu WANG; Shenghao YANG

doi:10.12259/j.issn.2095-610X.S20220710

Volume 43 Issue 7

Jul. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(7): 80-85

Shizhou LI, Xiaoguang HE, Yan LIN, Yuxiao LI, Xi YANG, Xiaoyu WANG, Shenghao YANG. Clinical Analysis of Cervical Lymph Node Metastatic Squamous Cell Carcinoma of Unknown Primary Site[J]. Journal of Kunming Medical University, 2022, 43(7): 80-85. doi: 10.12259/j.issn.2095-610X.S20220710

Citation:

Shizhou LI, Xiaoguang HE, Yan LIN, Yuxiao LI, Xi YANG, Xiaoyu WANG, Shenghao YANG. Clinical Analysis of Cervical Lymph Node Metastatic Squamous Cell Carcinoma of Unknown Primary Site[J]. Journal of Kunming Medical University, 2022, 43(7): 80-85. doi: 10.12259/j.issn.2095-610X.S20220710

Citation:

Shizhou LI, Xiaoguang HE, Yan LIN, Yuxiao LI, Xi YANG, Xiaoyu WANG, Shenghao YANG. Clinical Analysis of Cervical Lymph Node Metastatic Squamous Cell Carcinoma of Unknown Primary Site[J]. Journal of Kunming Medical University, 2022, 43(7): 80-85. doi: 10.12259/j.issn.2095-610X.S20220710

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Clinical Analysis of Cervical Lymph Node Metastatic Squamous Cell Carcinoma of Unknown Primary Site

doi: 10.12259/j.issn.2095-610X.S20220710

Head and Neck Surgery，Second Department of Otolaryngology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2022-04-15
Available Online: 2022-06-25
Publish Date: 2022-07-14

Abstract

Abstract

Objective To analyze the clinical characteristics of squamous cell carcinoma with cervical lymph node metastasis of unknown primary （CCUP） focus, explore the prognostic factors, and provide the basis for clinical diagnosis and treatment. Methods The clinical data of 23 patients with CCUP who were admitted to our hospital from September 2018 to December 2020 were reviewed. Lymph node metastasis area, tumor stage, P16+, etc. were used as analysis indicators. Univariate analysis was used to establish Cox risk model to analyze prognostic factors. Results As of the end of follow-up, 19 patients survived and 4 died. There was no correlation between the survival prognosis of patients and the gender, course of disease, history of smoking and alcohol, EBV+, lymph node metastasis area, P16+, and whether the primary tumor was clear, and the difference was not statistically significant （all P > 0.05）, but it was related to the age of the patient. Correlation （P = 0.024 < 0.05）. In the N stage, the later the N stage, the lower the survival rate. The survival rate of patients with unknown primary tumor was lower and clinically significant, but the difference was not statistically significant. Conclusion The patients with CCUP have a short course of disease, and the level Ⅱ, Ⅲ neck lymph nodes are the most involved. EBV detection, P16 and other immunohistochemical staining are helpful for finding the primary site. The best diagnosis and treatment plan should be selected according to the patient’s condition to reduce tumor recurrence and improve the quality of life.
- Unknown primary tumor,
- Neck metastases,
- Squamous cell carcinoma,
- Prognosis

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References(16)

References

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