Clinical Characteristics of Talaromyces Marneffei Disease and Disseminated Nontuberculosis Mycobacterium Disease in AIDS Patients

Bo TIAN; Yinzhong SHEN; Jinsong BAI; Jun LIU; Haiyun CHEN; Jianjun SUN

doi:10.12259/j.issn.2095-610X.S20220718

Volume 43 Issue 7

Jul. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(7): 140-144

Bo TIAN, Yinzhong SHEN, Jinsong BAI, Jun LIU, Haiyun CHEN, Jianjun SUN. Clinical Characteristics of Talaromyces Marneffei Disease and Disseminated Nontuberculosis Mycobacterium Disease in AIDS Patients[J]. Journal of Kunming Medical University, 2022, 43(7): 140-144. doi: 10.12259/j.issn.2095-610X.S20220718

Citation:

Bo TIAN, Yinzhong SHEN, Jinsong BAI, Jun LIU, Haiyun CHEN, Jianjun SUN. Clinical Characteristics of Talaromyces Marneffei Disease and Disseminated Nontuberculosis Mycobacterium Disease in AIDS Patients[J]. Journal of Kunming Medical University, 2022, 43(7): 140-144. doi: 10.12259/j.issn.2095-610X.S20220718

Citation:

Bo TIAN, Yinzhong SHEN, Jinsong BAI, Jun LIU, Haiyun CHEN, Jianjun SUN. Clinical Characteristics of Talaromyces Marneffei Disease and Disseminated Nontuberculosis Mycobacterium Disease in AIDS Patients[J]. Journal of Kunming Medical University, 2022, 43(7): 140-144. doi: 10.12259/j.issn.2095-610X.S20220718

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Clinical Characteristics of Talaromyces Marneffei Disease and Disseminated Nontuberculosis Mycobacterium Disease in AIDS Patients

doi: 10.12259/j.issn.2095-610X.S20220718

1.
Dept. of Infection one，The Third People’s Hospital of Kunming/Yunnan Clinical Medical Center for Infectious Diseases，Kunming Yunnan 650041
2.
Dept. of Infection and Immunity，Shanghai Public Health Clinical Center，Shanghai 201508，China

Received Date: 2022-01-01
Available Online: 2022-06-16
Publish Date: 2022-07-14

Abstract

Abstract

Objective To compare the clinical characteristics and analyzing the risk factors for poor prognosis of Talaromyces Marneffei and disseminated Nontuberculosis Mycobacterium disease in AIDS patients . Methods We retrospectively collected the data of cases of Talaromyces Marneffei and disseminated Nontuberculosis Mycobacterium disease in Shanghai Public Health Clinical Center from 2015 to 2021. Then we compared the differences of clinical characteristics between the two groups, the risk factors for poor prognosis were also analyzed. Results The mean age in both groups were younger than 40 years and, the proportion of poor prognosis in NTM group was 24% while it was 17% in TM group. Compared to the NTM group, serum albumin was lower in group TM （P = 0.003）, Procalcitonin was higher （P = 0.002）, slower ESR （P = 0.011）, fungal D-glucan was higher （P < 0.001）. When CD8 less than 250/µL, the risk of poor prognosis was higher than patients with CD8 > 250/µL （P = 0.049） in the NTM group. Albumin < 30 g/L （P = 0.017） or endotoxin < 6 pg/ml （P = 0.022） were both independent risk factors for poor prognosis in the NTM group. The fungal D glucan less than 11pg/mL （P = 0.016） or CD8 < 250/µL （P = 0.012） were both independent risk factors for poor prognosis in the TM group. Conclusions In AIDS patients, people infected with Talaromyces Marneffei have lower albumin than disseminated Nontuberculous Mycobacterium and need to pay close attention to timely supplement. Cases in both TM and NTM groups have high mortality. Higher levels of CD8 indicate a better prognosis.
- HIV,
- AIDS,
- Talaromyces Marneffei,
- Non-tuberculous Mycobacteria,
- Clinical characteristics,
- Prognosis

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References(22)

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