Real-world Data Analysis to Evaluate the Antiplatelet Efficacy of Clopidogrel Bisulfate After Stent Implantation with Volume Collection and Original Research

Xiaodong ZHANG; Long YANG; Wenhong SONG; Hongming LIU; Wei HU; Zhisong CHEN; Zhuo YU

doi:10.12259/j.issn.2095-610X.S20220728

Volume 43 Issue 7

Jul. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(7): 105-109

Xiaodong ZHANG, Long YANG, Wenhong SONG, Hongming LIU, Wei HU, Zhisong CHEN, Zhuo YU. Real-world Data Analysis to Evaluate the Antiplatelet Efficacy of Clopidogrel Bisulfate After Stent Implantation with Volume Collection and Original Research[J]. Journal of Kunming Medical University, 2022, 43(7): 105-109. doi: 10.12259/j.issn.2095-610X.S20220728

Citation:

Xiaodong ZHANG, Long YANG, Wenhong SONG, Hongming LIU, Wei HU, Zhisong CHEN, Zhuo YU. Real-world Data Analysis to Evaluate the Antiplatelet Efficacy of Clopidogrel Bisulfate After Stent Implantation with Volume Collection and Original Research[J]. Journal of Kunming Medical University, 2022, 43(7): 105-109. doi: 10.12259/j.issn.2095-610X.S20220728

Citation:

Xiaodong ZHANG, Long YANG, Wenhong SONG, Hongming LIU, Wei HU, Zhisong CHEN, Zhuo YU. Real-world Data Analysis to Evaluate the Antiplatelet Efficacy of Clopidogrel Bisulfate After Stent Implantation with Volume Collection and Original Research[J]. Journal of Kunming Medical University, 2022, 43(7): 105-109. doi: 10.12259/j.issn.2095-610X.S20220728

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Real-world Data Analysis to Evaluate the Antiplatelet Efficacy of Clopidogrel Bisulfate After Stent Implantation with Volume Collection and Original Research

doi: 10.12259/j.issn.2095-610X.S20220728

1.
Sec-Dept. of Geriatric Cardiology，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
Dept. of Cardiology，The 2nd Affiliated Hospital of Dalian Medical University，Dalian Liaoning 116023
3.
Dept. of Pharmacy，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2022-05-26
Publish Date: 2022-07-25

Abstract

Abstract

Objective To explore the anti-platelet efficacy of national bulk collection and original clopidogrel bisulfate after stent implantation in patients with acute coronary syndrome （ACS） in the real world. Methods We established a real-world database of patients with acute coronary syndrome （ACS） after stent implantation. After stent implantation, the patients were divided into the group with dose collection and the control group, and the baseline variables and outcome variables were constructed, and the two groups were matched according to the propensity score of 1∶1. The antiplatelet effects and adverse drug reactions were compared between the two groups after oral administration of double doses of clopidogrel （75 mg, BID） for one month and then adjusted to the general maintenance dose （75 mg, QD） for one year. Results 1. There was no significant difference in the ADP inhibition rate between the two groups on the 5th day after oral intensive dose （P > 0.05）, but the ADP inhibition rate on the 5th day after oral maintenance dose was increased after one month, and there was significant difference between the two groups before and after oral intensive dose （ P < 0.05）. There was no significant difference in the increase of ADP inhibition rate between the maintenance dose and the intensive dose on the 5th day （ P > 0.05）. 2. There was no significant difference in MA-ADP between the two groups on the fifth day of oral intensive dose （ P > 0.05）, and there was no significant difference in MA-ADP between the two groups on the fifth day of oral maintenance dose after one month （ P > 0.05）, but there was significant difference within the group （ P < 0.05）; There was no significant difference in whether MA-ADP fell within the normal therapeutic window at two different time points between the two groups （ P > 0.05）. 3. Compared with the original clopidogrel （ C/E = 2.124）, the pooled clopidogrel （C/E = 0.840） had a better average cost-effectiveness pharmacoeconomic effect. Conclusion There is no significant difference in antiplatelet efficacy and safety between pooled clopidogrel and original clopidogrel in the intensive dose period or maintenance dose period of antiplatelet after PCI.
- Clopidogrel,
- Acute Coronary Syndrome,
- Thromboelastography,
- Drug efficacy

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References(10)

References

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