Research Progress in Pathogenesis of Diabetic Encephalopathy

Cuiling WU; Hongyi LIU; Yuan FAN; Jiarui LIU

doi:10.12259/j.issn.2095-610X.S20220733

Volume 43 Issue 7

Jul. 2022

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Cuiling WU, Hongyi LIU, Yuan FAN, Jiarui LIU. Research Progress in Pathogenesis of Diabetic Encephalopathy[J]. Journal of Kunming Medical University, 2022, 43(7): 145-151. doi: 10.12259/j.issn.2095-610X.S20220733

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Cuiling WU, Hongyi LIU, Yuan FAN, Jiarui LIU. Research Progress in Pathogenesis of Diabetic Encephalopathy[J]. Journal of Kunming Medical University, 2022, 43(7): 145-151. doi: 10.12259/j.issn.2095-610X.S20220733

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Research Progress in Pathogenesis of Diabetic Encephalopathy

doi: 10.12259/j.issn.2095-610X.S20220733

Cuiling WU¹,
Hongyi LIU²,
Yuan FAN^{1, 3
,
,},
Jiarui LIU^{3
,
,}

1.
First School of Clinic Medicine，Yunnan University of Traditional Chinese Medicine，Kunming Yunnan 650500
2.
Dept. of Endocrinology，Yunnan Provincial Hospital of Traditional Chinese Medicine，Kunming Yunnan 650041
3.
Dept. of Endocrinology，The Second Affiliated Hospital of Yunnan University of Traditional Chinese Medicine，Kunming Yunnan 650216，China

Received Date: 2022-01-14
Publish Date: 2022-07-14

Abstract

Abstract

Diabetic encephalopathy （DE） is one of the chronic complications associated with diabetes. It is affected by many risk factors. Its main clinical manifestations are cognitive impairment, decision making disorders and emotional disorders. At present, the possible pathogenesis is pancreatic amyloid polypeptide homeostasis imbalance, MicroRNAs, macrophage autophagy, lipoprotein Lipin1, advanced glycation end products （AGEs）, oxidative stress, overphosphorylation of Tau protein, calcium homeostasis, and other mechanisms, which affect the function of brain tissue cells and cause corresponding pathological changes of diabetic encephalopathy. Promote the development of diabetic encephalopathy.
- Diabetic encephalopathy,
- Type 3 diabetes,
- Cognitive dysfunction,
- Pathogenesis

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References(50)

References

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