Efficacy of Blood Transfusion Combined with Chemoradiotherapy in Patients with Colorectal Cancer and its Effect on Tumor Markers and T Lymphocyte Levels

Yan WANG; Rong DING; Lvling ZHANG; Ruohua WANG; Xiaoling ZHAO; Na MA

doi:10.12259/j.issn.2095-610X.S20220809

Volume 43 Issue 8

Jul. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(8): 61-65

Yan WANG, Rong DING, Lvling ZHANG, Ruohua WANG, Xiaoling ZHAO, Na MA. Efficacy of Blood Transfusion Combined with Chemoradiotherapy in Patients with Colorectal Cancer and its Effect on Tumor Markers and T Lymphocyte Levels[J]. Journal of Kunming Medical University, 2022, 43(8): 61-65. doi: 10.12259/j.issn.2095-610X.S20220809

Citation:

Yan WANG, Rong DING, Lvling ZHANG, Ruohua WANG, Xiaoling ZHAO, Na MA. Efficacy of Blood Transfusion Combined with Chemoradiotherapy in Patients with Colorectal Cancer and its Effect on Tumor Markers and T Lymphocyte Levels[J]. Journal of Kunming Medical University, 2022, 43(8): 61-65. doi: 10.12259/j.issn.2095-610X.S20220809

Citation:

Yan WANG, Rong DING, Lvling ZHANG, Ruohua WANG, Xiaoling ZHAO, Na MA. Efficacy of Blood Transfusion Combined with Chemoradiotherapy in Patients with Colorectal Cancer and its Effect on Tumor Markers and T Lymphocyte Levels[J]. Journal of Kunming Medical University, 2022, 43(8): 61-65. doi: 10.12259/j.issn.2095-610X.S20220809

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Efficacy of Blood Transfusion Combined with Chemoradiotherapy in Patients with Colorectal Cancer and its Effect on Tumor Markers and T Lymphocyte Levels

doi: 10.12259/j.issn.2095-610X.S20220809

1.
Dept. of Blood Transfusion，Yunnan Cancer Hospital
2.
Dept. of Interventional Radiology，Kunming Yunnan 650118，China

Received Date: 2022-01-21
Available Online: 2022-07-18
Publish Date: 2022-08-25

Abstract

Abstract

Objective To investigate the efficacy of blood transfusion combined with radiotherapy and chemotherapy in patients with colorectal cancer and its effects on tumor markers and T lymphocyte levels. Methods A retrospective analysis was performed on 68 patients with colorectal cancer who received treatment in Yunnan Cancer Hospital from January 2018 to February 2020. These patients were divided into 2 groups based on their conditions and treatment plans. The control group （34 cases） received radiotherapy and chemotherapy, and the study group （34 cases） received blood transfusion combined with radiotherapy and chemotherapy. The clinical therapeutic effect, T lymphocyte level and tumor marker level were compared between the two groups. Results The clinical effective rate of the study group was siginificantly higher than that of the control group （P < 0.05）. Before treatment, there was no statistically significant difference in the levels of T lymphocyte cytokines between the two groups （P > 0.05）. After treatment, the levels of CD8+ in the study group were lower than those in the control group, while the levels of CD3+, CD4+ and CD4+/CD8+ were higher than those in the control group, with statistically significant differences （P > 0.05）. Before treatment, there were no statistically significant differences in the levels of CA19-9, TK1, CEA and AFP between 2 groups （P > 0.05）. After treatment, the levels of CA19-9, TK1, CEA and AFP in the study group were significantly lower than those in the control group （P < 0.05）. Conclusion Blood transfusion combined with radiotherapy and chemotherapy can improve the therapeutic effect, improve the level of tumor markers and enhance the immunity of colorectal cancer patients.
- Transfusion therapy,
- Radiotherary and chemotherapy,
- Colorectal cancer patients,
- Curative effect,
- Tumor markers,
- T lymphocyte level

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References(17)

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