Effect of Butylphthalide on NIHSS and Hemorheology in Patients with Acute Cerebral Infarction

Rong ZHANG; Xingju SONG; Lin Duan; Qian LI; Xu CHEN

doi:10.12259/j.issn.2095-610X.S20220810

Volume 43 Issue 8

Jul. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(8): 66-71

Rong ZHANG, Xingju SONG, Lin Duan, Qian LI, Xu CHEN. Effect of Butylphthalide on NIHSS and Hemorheology in Patients with Acute Cerebral Infarction[J]. Journal of Kunming Medical University, 2022, 43(8): 66-71. doi: 10.12259/j.issn.2095-610X.S20220810

Citation:

Rong ZHANG, Xingju SONG, Lin Duan, Qian LI, Xu CHEN. Effect of Butylphthalide on NIHSS and Hemorheology in Patients with Acute Cerebral Infarction[J]. Journal of Kunming Medical University, 2022, 43(8): 66-71. doi: 10.12259/j.issn.2095-610X.S20220810

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Effect of Butylphthalide on NIHSS and Hemorheology in Patients with Acute Cerebral Infarction

doi: 10.12259/j.issn.2095-610X.S20220810

1.
Dept. of Neurology
2.
Dept .of Neurosurgery，Kunming Second People’s Hospital， Kunming Yunnan 650041，China

Received Date: 2022-03-09
Publish Date: 2022-08-25

Abstract

Abstract

Objective To investigate the influence of butylphthalide on National Institute of Health stroke Scale （NIHSS） and hemorheology in patients with acute cerebral infarction. Methods A total of 66 patients with acute cerebral infarction admitted to the Department of Neurology of Kunming Second People’s Hospital from March 2020 to April 2021 were selected and divided into study group and control group by numerical random table method. The control group received routine treatment, and the research group was treated with butylphthalide on the basis of routine treatment as in the control group. Hemorheology, efficacy of the two groups before and after treatment, neurological deficit score and adverse reactions of daily living ability were detected and compared. Results After treatment, the total effective rate of the study group was higher than that of the control group, and the difference was statistically significant （P < 0.05）. After treatment, the NHISS score of the study group was lower than that of the control group, and the Barthel index was higher than that of the control group, with statistical significance （ P < 0.05）. After treatment, the hemorheology indexes （whole blood specific viscosity, plasma specific viscosity, hematocrit and platelet aggregation rate）in the study group were lower than those in the control group, and the differences were statistically significant （ P < 0.05）. There was no significant difference in the adverse reaction rate between the study group and the control group （ P > 0.05）. Conclusion The use of butylphthalide for the treatment of acute cerebral infarction patients is effective, with improvement in patients’ neurological functions and hemorheology indicators. It is safe and worthy of application and promotion.
- Acute cerebral infarction,
- Butyl phthalide,
- Neurological impairment,
- Hemorheology,
- Clinical efficacy,
- Adverse reactions

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References(38)

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