Effect of Early Interventional Palliative Treatment on Pain and Anxiety in Patients with Hepatitis-Related Liver Cancer

Xi GUO; Xiaoqing TANG; Jie WANG; Yan WAN; Bin XU; Yu LUO

doi:10.12259/j.issn.2095-610X.S20220813

Volume 43 Issue 8

Jul. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(8): 93-99

Xi GUO, Xiaoqing TANG, Jie WANG, Yan WAN, Bin XU, Yu LUO. Effect of Early Interventional Palliative Treatment on Pain and Anxiety in Patients with Hepatitis-Related Liver Cancer[J]. Journal of Kunming Medical University, 2022, 43(8): 93-99. doi: 10.12259/j.issn.2095-610X.S20220813

Citation:

Xi GUO, Xiaoqing TANG, Jie WANG, Yan WAN, Bin XU, Yu LUO. Effect of Early Interventional Palliative Treatment on Pain and Anxiety in Patients with Hepatitis-Related Liver Cancer[J]. Journal of Kunming Medical University, 2022, 43(8): 93-99. doi: 10.12259/j.issn.2095-610X.S20220813

Citation:

Xi GUO, Xiaoqing TANG, Jie WANG, Yan WAN, Bin XU, Yu LUO. Effect of Early Interventional Palliative Treatment on Pain and Anxiety in Patients with Hepatitis-Related Liver Cancer[J]. Journal of Kunming Medical University, 2022, 43(8): 93-99. doi: 10.12259/j.issn.2095-610X.S20220813

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Effect of Early Interventional Palliative Treatment on Pain and Anxiety in Patients with Hepatitis-Related Liver Cancer

doi: 10.12259/j.issn.2095-610X.S20220813

Dept. of Oncology，Kunming Third People’s Hospital，Kunming Yunnan 650041，China

Received Date: 2021-10-07
Publish Date: 2022-08-25

Abstract

Abstract

Objective To explore the effect of integrating palliative care to reduce the pain and anxiety symptoms of liver cancer patients. Methods 60 patients with hepatitis related liver cancer in Kunming Third People’s Hospital were divided into standard treatment group （control group）（n = 30） and palliative interventional treatment group （n = 30）（study group）. The control group received interventional treatment, and the study group received interventional treatment plus palliative treatment. Patients in the two groups were evaluated by pain scale and anxiety scale respectively after interventional treatment. After 12 weeks, the two groups were evaluated again with the scales mentioned above, and the pain and anxiety scores of the two groups were compared before and after 12 weeks, to analyze the factors influencing the pain and depression in patients with hepatitis related liver cancer, and to analyze the correlation between the related factors in the pain and anxiety scores of the two groups. Results There was no statistical significance in age, sex, education level, smoking history, alcoholism history, medical insurance type, liver function grade and hepatitis type between the two treatment groups （P > 0.05）. There were statistically significant differences in family background, pain history, tumor stage, ECOG score, NRS score before treatment, NRS score after treatment, anxiety score before treatment and anxiety score after treatment between the 2 treatment groups （ P < 0.05）. After 12 weeks of treatment, the pain and anxiety scores of the patients in the control group were significantly higher than those in the research group （ P < 0.05）. Conclusion Palliative care combined with standard treatment has significant effects on alleviating pain and anxiety, and the earlier the palliative care program is entered, the better the improvement of patients’ pain and anxiety. Therefore, palliative care is not limited to patients with advanced liver cancer.
- Liver cancer,
- Interventional therapy,
- Palliative care,
- Pain,
- Anxiety,
- Impact analysis

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References(31)

References

[1]	Hang T,Wedd J P. The optimal timing and management of hepatitis B and C in patients with hepatocellular carcinoma[J]. Chinese Clinical Oncology,2020,9(3):1-7.
[2]	Aducio L. Hepatocellular carcinoma in adults[M] . Brisbane （AU）: Exon Publications, 2021: 39-54.
[3]	Iezzi Roberto,Bilhim Tiago,Crocetti Laura,et al. "Primum Non Nocere" in interventional oncology for liver cancer:How to reduce the risk for complications?[J]. Life (Basel),2020,21(1):1-13.
[4]	Woodrell Christopher D,Hansen Lissi,Schiano Thomas D,et al. Palliative care for people with hepatocellular carcinoma,and specific benefits for older adults.[J]. Clin Ther,2018,40(4):512-525. doi: 10.1016/j.clinthera.2018.02.017
[5]	Goldstein Elisha,Yeghiazaryan Kristina,Ahmad Ashar,et al. Optimal multiparametric set-up modelled for best survival outcomes in palliative treatment of liver malignancies:Unsupervised machine learning and 3 PM recommendations[J]. EPMA J,2020,11(6):505-515.
[6]	Temel J S,Greer J A,Muzikansky A,et al. Early palliative care for patients with metastatic non-small-cell lung cancer[J]. N Engl J Med,2010,363(8):733-742. doi: 10.1056/NEJMoa1000678
[7]	Soeda Akio, Ⅳ. Palliative care for malignant brain tumor patients[J]. Gan To Kagaku Ryoho,2022,49:666-668.
[8]	L ü tscher Jamie, Siegenthaler Christa Hauswirth, Hertler Caroline, et al. Retrospective analysis of emotional burden and the need for support of patients and their informal caregivers after palliative radiation treatment for brain metastases[J]. Curr Oncol,2022,29:4235-4244.
[9]	Karapanos Konstantinos,Nomikos Iakovos N. Current surgical aspects of palliative treatment for unresectable pancreatic cancer[J]. Cancers (Basel),2011,3(1):636-651. doi: 10.3390/cancers3010636
[10]	Ivers Rowena,Jackson Brad,Levett Trish,et al. Home to health care to hospital:Evaluation of a cancer care team based in australian aboriginal primary care[J]. Aust J Rural Health,2019,27(1):88-92. doi: 10.1111/ajr.12484
[11]	Chvetzoff Gisele, Girodet Magali, Despax Johanna et al. Reasons for acceptance and refusal of early palliative care in patients included in early-phase clinical trials in a regional comprehensive cancer centre in France: Protocol for a qualitative study[J]. BMJ Open,2022,12:1-6.
[12]	许文涛,景婧,王仲霞,等. 肝癌治疗新时代中西医结合治疗策略探析[J]. 中西医结合肝病杂志,2019,29(6):564-566.
[13]	中华人民共和国国家卫生健康委员会医政医管局. 原发性肝癌诊疗指南(2022年版)[J]. 肿瘤综合治疗电子杂志,2022,8(2):16-53.
[14]	丛明华,石汉平. 中国恶性肿瘤患者运动治疗专家共识[J]. 中国科学:生命科学,2022,52(4):587-602.
[15]	中华人民共和国卫生部. 癌症疼痛诊疗规范(2011年版)[J]. 中华危重症医学杂志(电子版),2012,5(1):31-38. doi: 10.3877/cma.j.issn.1674-6880.2012.01.006
[16]	李宗艳,施雁,陈静娟,等. 癌症患者心理焦虑测评工具的研究进展[J]. 淮海医药,2021,39(3):326-329. doi: 10.14126/j.cnki.1008-7044.2021.03.037
[17]	Liu Zhenqiu,Suo Chen,Mao Xianhua,et al. Global incidence trends in primary liver cancer by age at diagnosis,sex,region,and etiology,1990-2017[J]. Cancer,2020,126(10):2267-2278. doi: 10.1002/cncr.32789
[18]	孙锋,张俊青,王茜. 合肥市居民吸烟、饮酒行为与心理健康状况的关系[J]. 中国卫生工程学,2018,17(2):210-212.
[19]	Li Chuanzhen,Yuan Juan,Huang Xiaoxiao,et al. Correlation between depression and intimacy in lung cancer patients and their family caregivers.[J]. BMC Palliat Care,2022,21:99. doi: 10.1186/s12904-022-00992-7
[20]	Jiang Chun-Hong,Zhu Feng,Qin Ting-Ting. Relationships between chronic diseases and depression among Middle-aged and elderly people in China:A prospective study from CHARLS[J]. Curr Med Sci,2020,40(5):858-870. doi: 10.1007/s11596-020-2270-5
[21]	吴眉,高月求,张斌,等. 消瘤散联合姑息疗法治疗晚期原发性肝癌的临床观察简[J]. 上海中医药杂志,2017,51(S1):77-79.
[22]	Nogueira García Jessica,Moreno Selva Rocío,Ruiz Sánchez María Esther,et al. [Uterine artery embolization as palliative treatment in cervical cancer][J]. Ginecol Obstet Mex,2015,83(5):289-293.
[23]	Xie Chan Juan,Xu Xiang Hua,Ou Mei Jun,et al. Chinese version of the psychological inflexibility in pain scale for cancer patients reporting chronic pain[J]. Cancer Nurs,2021,44(3):180-189. doi: 10.1097/NCC.0000000000000772
[24]	Guo Congying,Huang Xuan. Hospital anxiety and depression scale exhibits good consistency but shorter assessment time than Zung self-rating anxiety/depression scale for evaluating anxiety/depression in non-small cell lung cancer[J]. Medicine (Baltimore),2021,100(8):24428.
[25]	Chan L M, Ng S C J. Prevalence and correlates of caregiver anxiety in family caregivers of patients with advanced cancer: A cross-sectional study in a palliative care unit in Hong Kong[J]. East Asian Arch Psychiatry,2022,32:27-33.
[26]	Atinafu Bantalem Tilaye, Demlew Tefera Mulugeta, Tarekegn Fetene Nigussie. Magnitude of anxiety and depression and associated factors among palliative care patients with cancer at tikur anbessa specialized hospital, ethiopia[J]. Ethiop J Health Sci,2022,32:331-342.
[27]	Saraiya Biren, Dale William, Singer Eric A, et al. Integration of Palliative and supportive care into the management of genitourinary malignancies[J]. Am Soc Clin Oncol Educ Book,2022,42:1-10.
[28]	Takeda Kazuya, Sakayauchi Toru, Kubozono Masaki, et al. Palliative radiotherapy for gastric cancer bleeding: A multi-institutional retrospective study[J]. BMC Palliat Care,2022,21:52.
[29]	Ito Kei, Ogoshi Yumi, Shimizuguchi Takuya. Palliative radiotherapy for multiple liver metastases: A retrospective analysis of 73 cases[J]. Jpn J Clin Oncol,2022,52:771-776.
[30]	Beaudet Marc-Étienne, Lacasse Yves, Labb é Catherine. Palliative systemic therapy given near the end of life for metastatic non-small cell lung cancer[J]. Curr Oncol,2022,29:1316-1325.
[31]	George Reena, Rai Bhavana. Practical aspects of palliative care & palliative radiotherapy in incurable cervical cancer[J]. Indian J Med Res,2021,154:262-266.

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