Volume 43 Issue 8
Jul.  2022
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Yike ZHU, Junsu YANG, Fang QIAN, Haohao WU, Baogang HUANG. Correlation between NLR Value and Prognosis in Patients with Acute Ischemic Stroke before and after Revascularization[J]. Journal of Kunming Medical University, 2022, 43(8): 100-105. doi: 10.12259/j.issn.2095-610X.S20220815
Citation: Yike ZHU, Junsu YANG, Fang QIAN, Haohao WU, Baogang HUANG. Correlation between NLR Value and Prognosis in Patients with Acute Ischemic Stroke before and after Revascularization[J]. Journal of Kunming Medical University, 2022, 43(8): 100-105. doi: 10.12259/j.issn.2095-610X.S20220815

Correlation between NLR Value and Prognosis in Patients with Acute Ischemic Stroke before and after Revascularization

doi: 10.12259/j.issn.2095-610X.S20220815
  • Received Date: 2022-04-22
    Available Online: 2022-07-20
  • Publish Date: 2022-07-28
  •   Objective  To study the influencing factors of poor prognosis before and after revascularization of acute ischemic stroke, so as to provide more biomarkers for prognosis prediction.   Methods   A total of 179 patients with acute ischemic stroke who received revascularization therapy (including intravenous thrombolysis, mechanical thrombectomy, or both) admitted to the Department of Neurology and The Department of Neurointervention of Qujing Hospital Affiliated to Kunming Medical University from December 2020 to October 2021 were collected. According to mRS score after 3 months, the patients were divided into good prognosis group (mRS < 3) and poor prognosis group (mRS≥3). General data, clinical test indicators, NLR value and NIHSS score before and after revascularization were compared between the two groups, and independent risk factors of patients with poor prognosis were further analyzed.   Results   There are siginificant differences in triglyceride, total cholesterol, c-reactive protein, NIHSS score, the number of neutrophils and percentage of the hospital, lymphocyte count and percentage, NLR value and reascularization 8 hours after the number of white blood cells, neutrophils and percentage, lymphocyte count and percentage, NLR value between the two groups (P < 0.05). Multivariate Logistic regression analysis showed that admission NIHSS score (OR=1.123, 95%CI 1.065-1.184, P < 0.05) was an independent risk factor for poor prognosis 3 months after revascularization in AIS patients, with a clinical diagnostic cut-off value of 11. The NLR values of the poor prognosis group before and after revascularization were higher than those of the good prognosis group, the difference was statistically significant (P < 0.05). The NLR values of AIS patients after revascularization were higher than those before revascularization, the difference was statistically significant (P < 0.05).   Conclusion   NIHSS score at admission is an independent risk factor for poor prognosis at 3 months in patients with AIS revascularization. Changes in NLR in AIS patients before and after revascularization showed an upward trend, and NLR in the poor prognosis group was higher than that in the good prognosis group before and after revascularization, but it was not an independent risk factor for poor prognosis in AIS patients 3 months after revascularization.
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  • [1]
    Liu J,Shi Z,Bai R,et al. Temporal,geographical and demographic trends of stroke prevalence in China:A systematic review and meta-analysis[J]. Ann Transl Med,2020,8(21):1432. doi: 10.21037/atm-19-4342
    [2]
    M ü ller S,Kufner A,Dell’Orco A,et al. Evolution of bood-brain barrier permeability in subacute ischemic stroke and associations with serum biomarkers and functional outcome[J]. Front Neurol,2021,12(6):730923.
    [3]
    中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组. 中国急性缺血性脑卒中诊治指南2018[J]. 中华神经科杂志,2018,51(9):666-682. doi: 10.3760/cma.j.issn.1006-7876.2018.09.004
    [4]
    Yu A Y,Hill M D,Coutts S B. Should minor stroke patients be thrombolyzed? A focused review and future directions[J]. Int J Stroke,2015,10(3):292-297. doi: 10.1111/ijs.12426
    [5]
    Zhang J,Yuan C,Deng X,et al. Efficacy and safety of endovascular treatment with or without intravenous alteplase in acute anterior circulation large vessel occlusion stroke:A meta-analysis of randomized controlled trials[J]. Neurol Sci,2022,22(9):207.
    [6]
    Świtońska M,Piekuś-Słomka N,Słomka A,et al. Neutrophil-to-lymphocyte ratio and symptomatic hemorrhagic transformation in ischemic stroke patients undergoing revascularization[J]. Brain Sci,2020,10(11):771. doi: 10.3390/brainsci10110771
    [7]
    徐慈航,李敬伟,朱晓蕾,等. 急性缺血性卒中出血转化的研究进展[J]. 中国卒中杂志,2020,15(4):446-451. doi: 10.3969/j.issn.1673-5765.2020.04.020
    [8]
    Lee Y B,Yoon W,Lee Y Y,et al. Predictors and impact of hemorrhagic transformations after endovascular thrombectomy in patients with acute large vessel occlusions[J]. J Neurointerv Surg,2019,11(5):469-473. doi: 10.1136/neurintsurg-2018-014080
    [9]
    Zhang W B,Zeng Y Y,Wang F,et al. A high neutrophil-to-lymphocyte ratio predicts hemorrhagic transformation of large atherosclerotic infarction in patients with acute ischemic stroke[J]. Aging (Albany NY),2020,12(3):2428-2439. doi: 10.18632/aging.102752
    [10]
    Weng Y,Zeng T,Huang H,et al. Systemic immune-inflammation index predicts 3-month functional outcome in acute ischemic stroke patients treated with intravenous thrombolysis[J]. Clin Interv Aging,2021,16(1):877-886.
    [11]
    Khatri R, McKinney A M, Swenson B, Janardhan V. Blood-brain barrier, reperfusion injury, and hemorrhagic transformation in acute ischemic stroke[J]. Neurology, 2012 , 79(13 Suppl 1): 52–57.
    [12]
    Maestrini I,Strbian D,Gautier S,et al. Higher neutrophil counts before thrombolysis for cerebral ischemia predict worse outcomes[J]. Neurology,2015,85(16):1408-1416. doi: 10.1212/WNL.0000000000002029
    [13]
    Liu Y L,Lu J K,Yin H P,et al. High Neutrophil-to-lymphocyte ratio predicts hemorrhagic transformation in acute ischemic stroke patients treated with intravenous thrombolysis[J]. Int J Hypertens,2020,2020(3):5980261.
    [14]
    Semerano A,Laredo C,Zhao Y,et al. Leukocytes,collateral circulation,and reperfusion in ischemic stroke patients treated with mechanical thrombectomy[J]. Stroke,2019,50(12):3456-3464. doi: 10.1161/STROKEAHA.119.026743
    [15]
    刘畅,董萌,刘继红,等. 急性脑梗死患者静脉溶栓前中性粒细胞百分比与溶栓后临床结局的关系[J]. 中国当代医药,2020,27(19):77-80. doi: 10.3969/j.issn.1674-4721.2020.19.022
    [16]
    Köm ü rc ü H F,Gözke E,Doğan Ak P,et al. Changes in neutrophil,lymphocyte,platelet ratios and their relationship with NIHSS after rtPA and/or thrombectomy in ischemic stroke[J]. J Stroke Cerebrovasc Dis,2020,29(8):105004. doi: 10.1016/j.jstrokecerebrovasdis.2020.105004
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