Correlation Between Silva Type and Prognosis of Cervical HPV-associated Adenocarcinoma

Changmeng HU; Lin WU

doi:10.12259/j.issn.2095-610X.S20220817

Volume 43 Issue 8

Jul. 2022

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Changmeng HU, Lin WU. Correlation Between Silva Type and Prognosis of Cervical HPV-associated Adenocarcinoma[J]. Journal of Kunming Medical University, 2022, 43(8): 113-121. doi: 10.12259/j.issn.2095-610X.S20220817

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Changmeng HU, Lin WU. Correlation Between Silva Type and Prognosis of Cervical HPV-associated Adenocarcinoma[J]. Journal of Kunming Medical University, 2022, 43(8): 113-121. doi: 10.12259/j.issn.2095-610X.S20220817

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Correlation Between Silva Type and Prognosis of Cervical HPV-associated Adenocarcinoma

doi: 10.12259/j.issn.2095-610X.S20220817

Changmeng HU^{1, 2},
Lin WU^{1
,
,}

1.
Dept. of Pathology，The 3rd Affiliated Hospital of Kunming Medical University/Yunnan Cancer Hospital，Kunming Yunnan 650118
2.
Dept. of Pathology，The 3rd People’s Hospital of Honghe Prefecture，Gejiu Yunnan 661000，China

Received Date: 2022-04-27
Available Online: 2022-07-22
Publish Date: 2022-07-28

Abstract

Abstract

Objective To investigate the application value of Silva typing pattern in prognosis of HPV-associated endocervicalnadenocarcinoma （HPVA）. Methods A total of 95 cases of invasive HPVA diagnosed by pathology department in the Third Affiliated Hospital of Kunming Medical University from February 2013 to December 2018 were collected and reclassified by Silva classification criteria. Clinicopathological features. According to the case data and follow-up, the survival rate was estimated and the influencing factors were analyzed. Results （1） Compared with SilvaA subtypes, SilvaB and C subtypes had larger tumor diameter, deeper myometrial invasion, poor differentiation, later FIGO stage, higher risk classification, and a higher proportion of pelvic and abdominal lymph node metastasis and nerve invasion. , postoperative adjuvant therapy was also more active （P < 0.05）, but there was no significant difference in age and lymphovascular invasion （P > 0.05）; （2） The 5-year overall survival rate and 5-year disease-free survival rate of SilvaA and SilvaB were higher than 90%, while those of SilvaC were significantly lower than 50% （P < 0.05）. （3） COX proportional hazards model multivariate analysis: pelvic and abdominal lymph node metastasis （HR = 12.602, 95%CI: 2.722-58.333） was the influence Independent factors of OS in patients with invasive HPVA （P = 0.001）; FIGO stage was an independent factor affecting DFS of patients with invasive HPVA （P < 0.05）. The 95%CI were 5.319 （1.597-17.716）, 53.365 （5.458-521.734）, and 25.982 （2.169-311.299）. Conclusion Silva classification pattern is closely related to tumor diameter, degree of differentiation, depth of muscle invasion, FIGO stage, pelvic and abdominal lymph node metastasis, nerve invasion, risk classification, postoperative adjuvant therapy, but not age, lymphovascular invasion . Pelvic and abdominal lymph node metastasis and FIGO stage are risk factors affecting the prognosis of cervical invasive HPVA.
- Silva classification,
- HPVA,
- Clinicopathological features,
- Prognosis

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References(21)

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