Clinical Characteristics of Varicella-zoster Virus Infection in 38 Immunocompromised Patients

Hua HE; Jinghua FAN; Yanling ZHANG; Yang LI; Haiwen LI; Yan WU

doi:10.12259/j.issn.2095-610X.S20220820

Volume 43 Issue 8

Jul. 2022

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2022 > 43(8): 127-131

Hua HE, Jinghua FAN, Yanling ZHANG, Yang LI, Haiwen LI, Yan WU. Clinical Characteristics of Varicella-zoster Virus Infection in 38 Immunocompromised Patients[J]. Journal of Kunming Medical University, 2022, 43(8): 127-131. doi: 10.12259/j.issn.2095-610X.S20220820

Citation:

Hua HE, Jinghua FAN, Yanling ZHANG, Yang LI, Haiwen LI, Yan WU. Clinical Characteristics of Varicella-zoster Virus Infection in 38 Immunocompromised Patients[J]. Journal of Kunming Medical University, 2022, 43(8): 127-131. doi: 10.12259/j.issn.2095-610X.S20220820

Citation:

PDF( 625 KB)

Clinical Characteristics of Varicella-zoster Virus Infection in 38 Immunocompromised Patients

doi: 10.12259/j.issn.2095-610X.S20220820

1.
Dept. of Infectious Diseases，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
Dept. of Infectious Diseases，The 3rd People’s Hospital of Kunming/Clinical Medical Center for Infectious Diseases of Yunnan Province，Kunming Yunnan 650041，China

Received Date: 2022-03-28
Publish Date: 2022-08-25

Abstract

Abstract

Objective To investigate the clinical characteristics of varicella-zoster virus （VZV） infection in immunocompromised population. Methods From January 2020 to December 2021 in the Third People’s Hospital of Kunming, 38 cases of VZV infection in immunosuppressed population were selected as the observation group, and 40 cases of VZV infection in the general population were selected as the control group. The clinical data were retrospectively analyzed, and the indexes of cardiac enzymes, liver function, kidney function and other organs function evaluation in the two groups were observed. And IL-6, IL-8, CD+4 T lymphocytes and other indicators’s data were analyzed to evaluate the body’s immunity. Results The GGT/AST/ALT and LDH/CK of the observation group were significantly higher than those of the control group （P < 0.05）. There was no statistical significance in CREA between the two groups （ P > 0.05）. IL-6 and IL-8 in the observation group were significantly higher than those in the control group （ P < 0.05）. The number of CD4+T lymphocytes in the observation group was significantly lower than that in the control group （ P < 0.05）. Conclusion Immunocompromised population with VZV infection are more likely to induce cytokine storm, and are more often complicated with organ dysfunction or even organ failure. The disease progresses faster and is more severe. Early identification and treatment can improve the prognosis.
- Immunocompromised population,
- Varicella-zoster virus,
- Clinical signs,
- Analysis

FullText(HTML)

References(16)

References

[1]	王宇明, 李梦东. 实用传染病学[M]. 北京: 人民卫生出版社, 2016: 483-484.
[2]	World Health Organization. Varicella and herpes zoster vaccines: WHO position paper, June 2014[J]. Wkly Epidemiol Rec, 2014, 89 （25）: 265–87.
[3]	Kennedy P G E,Mogensen T H. Determinants of neurological syndromes caused by Varicella-Zoster virus (VZV)[J]. J NeuroVirol,2020,26(4):482-495. doi: 10.1007/s13365-020-00857-w
[4]	王春又,王欢,宋志强,等. 成人重症水痘合并多器官衰竭二例并文献复习[J]. 中国麻风皮肤病杂志,2021,37(2):96-99.
[5]	李兰娟, 任红. 传染病学[M]. 9 版. 北京: 人民卫生出版社, 2018: 85-88.
[6]	杨栋,甘云,伍晓梅,等. 重症水痘合并弥散性血管内凝血的临床分析[J]. 临床医学研究与实践,2020,5(22):84-85,88. doi: 10.19347/j.cnki.2096-1413.202022031
[7]	韩洋,费文敏,李可可,等. 免疫抑制剂的概念和类型[J]. 皮肤科学通报,2021,38(4):291-297.
[8]	龚非力. 医学免疫学[M]. 北京: 科学出版社, 2014: 47-48, 117.
[9]	Cakir F B,Timur C,Yoruk A,et al. Seroconversion status after single dose and double doses of varicella vaccination in children with leukemia[J]. Pediatr Hematol Oncol,2012,29(2):191-194. doi: 10.3109/08880018.2011.593093
[10]	秦新华,王芳,赵保玲,等. 丙种球蛋白用于小儿重症出血性水痘治疗中的效果分析[J]. 医药论坛杂志,2021,42(2):119-122.
[11]	陈莹莹. 益肾活血法干预小儿原发性肾病综合征对 NGAL、 KIM-1、IL-18 的影响[D]. 福州: 福建中医药大学硕士学位论文, 2017.
[12]	李珍,梅文龙,柴艳婷,等. IL-6 基因 rs1800796 多态性与小儿热性惊厥易感性的 Meta 分析[J]. 重庆医学,2017,46(15):2089-2093. doi: 10.3969/j.issn.1671-8348.2017.15.025
[13]	李由. 对普通水痘患儿与突破性水痘患儿T淋巴细胞亚群指标的对比分析[J].当代医药论丛, 2016, 14（22）: 90-91.
[14]	杨美蓉,蒋亦明. 水痘患者细胞免疫功能的检测及意义[J]. 内蒙古中医药,2008,27(11):107-108. doi: 10.3969/j.issn.1006-0979.2008.11.083
[15]	陈娓,刘军连. 带状疱疹发病机制的研究进展[J]. 中国医学文摘:皮肤科学,2017,34(1):33-38.
[16]	Monneret D,Mestari F,Djiavoudine S,et al. Wide-range CRP versus high-sensitivity CRP on Roche analyzers:Focus on lowgrade inflammation ranges and high-sensitivity cardiac troponin T levels[J]. Scand J Clin Lab Invest,2018,78(5):346-351. doi: 10.1080/00365513.2018.1471618

Relative Articles(20)

Relative Articles

[1]	Nihong LU, Honglu LIU, Yangjun CHEN, Meiyan LIU, Yongrui YANG, Yingrong DU. Analysis of Characteristic Indexes of Liver Injury Model Induced by Different Antituberculosis Drugs in Mice. Journal of Kunming Medical University, 2023, 44(6): 6-13. doi: 10.12259/j.issn.2095-610X.S20230615
[2]	Lin WANG, Lingjun SHEN, Haiwen LI, Xiaoyan WANG, Jianpeng GAO, Zhiqiang MA. Analysis of Nutritional Status and Immune Function of Tuberculosis Patients in Yunnan. Journal of Kunming Medical University, 2023, 44(1): 109-115. doi: 10.12259/j.issn.2095-610X.S20230116
[3]	Zichen ZHANG, Wei CHEN, Shuqin ZHENG, Zonghua CHEN, He JIANG, Yulan MIAO. Analysis of the Clinical Data of 498 Adult Patients with Particularly Severe Burns. Journal of Kunming Medical University, 2022, 43(10): 90-97. doi: 10.12259/j.issn.2095-610X.S20221025
[4]	Liu Xun Qiang . . Journal of Kunming Medical University,
[5]	Yang Li Wei . . Journal of Kunming Medical University,
[6]	Wang Guo Liang . . Journal of Kunming Medical University,
[7]	Liu Le Wan . . Journal of Kunming Medical University,
[8]	Shi Chao Kai . . Journal of Kunming Medical University,
[9]	Zhang Yan . . Journal of Kunming Medical University,
[10]	Li Jin Tao . . Journal of Kunming Medical University,
[11]	Long Zhi Ren . . Journal of Kunming Medical University,
[12]	Yang Fang . . Journal of Kunming Medical University,
[13]	Wang Cheng . . Journal of Kunming Medical University,
[14]	Lu Ni Hong . Clinical Characteristics of Pulmonary Tuberculosis Patients with and without HIV(+)/AIDS. Journal of Kunming Medical University,
[15]	Han Rui Ping . Surveillance of Arsenic Pollution in Yangzonghai Lake in Recent Three Years. Journal of Kunming Medical University,
[16]	. The Cause Analysis on the Failure of Tumor Cells Culture from Malignant Hydrothorax. Journal of Kunming Medical University,
[17]	Liu Lin Dong . . Journal of Kunming Medical University,
[18]	Zhang Min . . Journal of Kunming Medical University,
[19]	Li Wu . . Journal of Kunming Medical University,
[20]	He Mei Xuan . . Journal of Kunming Medical University,