Clinical Characteristics of Varicella-zoster Virus Infection in 38 Immunocompromised Patients

Hua HE; Jinghua FAN; Yanling ZHANG; Yang LI; Haiwen LI; Yan WU

doi:10.12259/j.issn.2095-610X.S20220820

Volume 43 Issue 8

Jul. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(8): 127-131

Hua HE, Jinghua FAN, Yanling ZHANG, Yang LI, Haiwen LI, Yan WU. Clinical Characteristics of Varicella-zoster Virus Infection in 38 Immunocompromised Patients[J]. Journal of Kunming Medical University, 2022, 43(8): 127-131. doi: 10.12259/j.issn.2095-610X.S20220820

Citation:

Hua HE, Jinghua FAN, Yanling ZHANG, Yang LI, Haiwen LI, Yan WU. Clinical Characteristics of Varicella-zoster Virus Infection in 38 Immunocompromised Patients[J]. Journal of Kunming Medical University, 2022, 43(8): 127-131. doi: 10.12259/j.issn.2095-610X.S20220820

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Clinical Characteristics of Varicella-zoster Virus Infection in 38 Immunocompromised Patients

doi: 10.12259/j.issn.2095-610X.S20220820

1.
Dept. of Infectious Diseases，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
Dept. of Infectious Diseases，The 3rd People’s Hospital of Kunming/Clinical Medical Center for Infectious Diseases of Yunnan Province，Kunming Yunnan 650041，China

Received Date: 2022-03-28
Publish Date: 2022-08-25

Abstract

Abstract

Objective To investigate the clinical characteristics of varicella-zoster virus （VZV） infection in immunocompromised population. Methods From January 2020 to December 2021 in the Third People’s Hospital of Kunming, 38 cases of VZV infection in immunosuppressed population were selected as the observation group, and 40 cases of VZV infection in the general population were selected as the control group. The clinical data were retrospectively analyzed, and the indexes of cardiac enzymes, liver function, kidney function and other organs function evaluation in the two groups were observed. And IL-6, IL-8, CD+4 T lymphocytes and other indicators’s data were analyzed to evaluate the body’s immunity. Results The GGT/AST/ALT and LDH/CK of the observation group were significantly higher than those of the control group （P < 0.05）. There was no statistical significance in CREA between the two groups （ P > 0.05）. IL-6 and IL-8 in the observation group were significantly higher than those in the control group （ P < 0.05）. The number of CD4+T lymphocytes in the observation group was significantly lower than that in the control group （ P < 0.05）. Conclusion Immunocompromised population with VZV infection are more likely to induce cytokine storm, and are more often complicated with organ dysfunction or even organ failure. The disease progresses faster and is more severe. Early identification and treatment can improve the prognosis.
- Immunocompromised population,
- Varicella-zoster virus,
- Clinical signs,
- Analysis

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References(16)

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