Comparison of Serum PCT, IL-6, SAA Levels and Clinical Characteristics between Rotavirus and Norovirus Enteritis in Children

Zhiying LU; Meifen WANG; Junchao PENG; Zengqing DU; Yunjiao LUO; Wei MA

doi:10.12259/j.issn.2095-610X.S20220823

Volume 43 Issue 8

Jul. 2022

Turn off MathJax

Article Contents

Abstract

References

Relative Articles

Article Navigation > Journal of Kunming Medical University > 2022 > 43(8): 138-144

Xinye YANG, Nian ZHANG, Sha MA, Linpei HUANG, Xueyi LI, Xiaoping HUANG, Mi ZHANG, Cuixian YANG, Xicheng WANG. Analysis of Laboratory Index Characteristics in Newly Treated Smear-Negative Pulmonary Tuberculosis Patients[J]. Journal of Kunming Medical University, 2024, 45(9): 56-61. doi: 10.12259/j.issn.2095-610X.S20240909

Citation:

Zhiying LU, Meifen WANG, Junchao PENG, Zengqing DU, Yunjiao LUO, Wei MA. Comparison of Serum PCT, IL-6, SAA Levels and Clinical Characteristics between Rotavirus and Norovirus Enteritis in Children[J]. Journal of Kunming Medical University, 2022, 43(8): 138-144. doi: 10.12259/j.issn.2095-610X.S20220823

Citation:

PDF( 742 KB)

Comparison of Serum PCT, IL-6, SAA Levels and Clinical Characteristics between Rotavirus and Norovirus Enteritis in Children

doi: 10.12259/j.issn.2095-610X.S20220823

Dept. of Infectious Diseases，Kunming Children’s Hospital，Yunnan Kunming 650028，China

Received Date: 2022-02-10
Publish Date: 2022-08-25

Abstract

Abstract

Objective To investigate the changes in serum PCT, IL-6, SAA levels and clinical characteristics of pediatric rotavirus （RV） and norovirus （NV） enteritis, and to analyze the factors for distinguishing the two. Methods In a prospective observational study, we selected children with watery diarrhea and diagnosed viral enteritis who were admitted to the Department of Infectious Diseases of Kunming Children’s Hospital from November 2019 to January 2021 as the research objects. Stool and venous blood samples were collected within 24 hours after admission for detection of fecal rotavirus and norovirus and determination of blood cells, serum procalcitonin （PCT）, interleukin-6 （IL-6） and serum amyloid A （SAA）. The gender, age, the most vomiting and diarrhea times within 24 h, complications, maximum BT, Vesikari score and other clinical characteristics of the children were analyzed by multivariate logistic regression and the accuracy of the model was assessed by ROC. Results 143 children were eligible, among which 76 were RV and 67 were NV. The maximum BT, the highest number of diarrhea within 24 hours, Vesikari score, neutrophil count （NEUT）, SAA, and the number of patients with body temperature > 38 ℃ were significantly higher in the RV group than those in the NV group （ P < 0.05）; There were no statistically significant differences in gender, age, the maximum number of vomiting at 24 h, complications, the number of people with Vesikari score ≥11, white blood cell count （WBC）, PCT, CRP, and IL-6 levels （ P > 0.05）. Multivariate logistic regression analysis showed that maximum BT, NEUT, and SAA were independent factors that distinguished the two. ROC was used to assess the accuracy of the model, and its AUC was 0.838 （95%CI: 0.770-0.907, P < 0.001）, maximum approximate den index （J = 0.573）, sensitivity was 83.6%, specificity was 73.7%. Conclusion RV enteritis causes more patients with higher fever （ > 38 ℃）, and there are more frequent diarrhea within 24 hours, which is more serious than NV enteritis. A model containing maximum BT, NEUT and SAA can assist pediatricians in differential diagnosis of infection by unknown pathogens.
- Rotavirus,
- Norovirus,
- Enteritis,
- PCT,
- IL-6,
- SAA,
- Clinical features

FullText(HTML)

References(20)

References

[1]	Rönnelid Y,Bonkoungou I J O,Ouedraogo N,et al. Norovirus and rotavirus in children hospitalised with diarrhoea after rotavirus vaccine introduction in Burkina Faso[J]. Epidemiology and Infect,2020,148(1):245.
[2]	Da Cruz Gouveia M A, Lins MTC, da Silva GAP. Acute diarrhea with blood: Diagnosis and drug treatment [J]. Jornal De Pediatria, 2020, 96（Suppl 1）: 20-28.
[3]	方铁夫,耿岚岚,龚四堂. 欧洲儿童急性胃肠炎处理循证指南(2014年版)[J]. 中华儿科杂志,2015,53(7):499-509. doi: 10.3760/cma.j.issn.0578-1310.2015.07.008
[4]	Shin H J,Kang S H,Moon H S,et al. Serum procalcitonin levels can be used to differentiate between inflammatory and non-inflammatory diarrhea in acute infectious diarrhea[J]. Medicine,2018,97(32):11795. doi: 10.1097/MD.0000000000011795
[5]	Aktaş O,Aydin H,Timurkan M O. A molecular study on the prevalence and coinfections of rotavirus,norovirus,astrovirus and adenovirus in children with gastroenteritis[J]. Minerva Pediatrica,2019,71(5):431-437.
[6]	Rossouw E,Brauer M,Meyer P,et al. Virus etiology,diversity and clinical characteristics in south african children hospitalised with gastroenteritis[J]. Viruses,2021,13(2):215. doi: 10.3390/v13020215
[7]	Zbinden A. Virale Gastroenteritis:Es muss nicht immer Norovirus sein[J]. Praxis,2019,108(5):335-339. doi: 10.1024/1661-8157/a003182
[8]	Hu M H,Lin K L,Wu C T,et al. Clinical characteristics and risk factors for seizures associated with norovirus gastroenteritis in childhood[J]. Journal of Child Neurology,2017,32(9):810-814.
[9]	Riera-Montes M,O'Ryan M,Verstraeten T. Norovirus and rotavirus disease severity in children:Systematic review and meta-analysis[J]. Pediatr Infect Dis J,2018,37(6):501-505.
[10]	Chen S M,Lin C P,Tsai J D,et al. The significance of serum and fecal levels of interleukin-6 and interleukin-8 in hospitalized children with acute rotavirus and norovirus gastroenteritis[J]. Pediatrics and Neonatology,2014,55(2):120-126. doi: 10.1016/j.pedneo.2013.05.008
[11]	Eschborn S,Weitkamp J H. Procalcitonin versus C-reactive protein:Review of kinetics and performance for diagnosis of neonatal sepsis[J]. Journal of Perinatology:Official Journal of the California Perinatal Association,2019,39(7):893-903. doi: 10.1038/s41372-019-0363-4
[12]	中华医学会儿科学分会医院感染管理与控制专业委员会. 血清降钙素原检测在儿童感染性疾病中的临床应用专家共识[J]. 中华儿科杂志,2019,57(1):9-15. doi: 10.3760/cma.j.issn.0578-1310.2019.01.005
[13]	杨雪利,白静,宋紫霞,等. 血清降钙素原联合可溶性髓样细胞触发受体-1对儿童细菌性腹泻和病毒性腹泻的鉴别诊断价值[J]. 中国当代儿科杂志,2020,22(8):887-89. doi: 10.7499/j.issn.1008-8830.2002191
[14]	武宇辉,杨燕澜,张蕾,等. 血清降钙素原在儿童急性病毒性腹泻病中的临床价值探讨[J]. 中国小儿急救医学,2016,23(12):830-833.
[15]	Del Giudice M,Gangestad S W. Rethinking IL-6 and CRP:Why they are more than inflammatory biomarkers,and why it matters[J]. Brain,Behavior,and Immunity,2018,70(2):61-75.
[16]	中国中西医结合学会检验医学专业委员会. 血清淀粉样蛋白A在感染性疾病中临床应用的专家共识[J]. 中华检验医学杂志,2019,42(3):186-192.
[17]	Sui Y D,Xin W N,Feng L L. Comparison of the clinical application values of PCT,hs-CRP and SAA detection in the early diagnosis of sepsis[J]. Pakistan Journal of Medical Sciences,2020,36(7):1683-1687.
[18]	Yang M,Liu Y,Dai J,et al. Apolipoprotein A-II induces acute-phase response associated AA amyloidosis in mice through conformational changes of plasma lipoprotein structure[J]. Sci Rep.,2018,8(1):5620.
[19]	Zhang Y,Zhang J,Sheng H,Li H,et al. Acute phase reactant serum amyloid A in inflammation and other diseases[J]. Advances in Clinical Chemistry,2019,90(1):25-80.
[20]	Sack G H Jr. Serum amyloid A (SAA) proteins[J]. Sub-Cellular Biochemistry,2020,94:421-436.

Relative Articles(20)

Relative Articles

[1]	Minhui ZHANG, Weidan YIN, Zhulin HU, Hua LI, Liwei ZHANG, Yuling REN. Clinical Features and Prognosis of Acute Macular Neuroretinopathy Associated with Novel Coronavirus Infection. Journal of Kunming Medical University, 2025, 46(4): 1-9.
[2]	Jianfang MA, Xiaoling HUANG, Yanhua LI, Di MA, Kaifen YUAN. Analysis of Clinical Characteristics and Death Risk Factors in Patients with Community-acquired Pneumonia Complicated with Diabetes. Journal of Kunming Medical University, 2024, 45(2): 123-130. doi: 10.12259/j.issn.2095-610X.S20240217
[3]	Shulan SHI, Lijuan QIU, Liyue KUI, Min SU, Bailing ZHOU, Rongjie LI, Jianming SUN. Diagnostic Value of Interleukin-6，Interleukin-10，High-sensitivity C-reactive Protein and Procalcitonin in Children with Acute Lymphoblastic Leukemia Complicated by Infection. Journal of Kunming Medical University, 2023, 44(1): 104-108. doi: 10.12259/j.issn.2095-610X.S20230115
[4]	Shuangshuang WANG, Liqin CHEN, Yaling LI, Weijie LI, Jiayi YANG. Analysis of Epidemiological Characteristics of Neonatal Rotavirus Infection from 2020 to 2022. Journal of Kunming Medical University, 2023, 44(5): 26-31. doi: 10.12259/j.issn.2095-610X.S20230509
[5]	Weijie LI, Liqin CHEN, Yaling LI, Yonghui HAN, Xiaojuan LI, Fendong YAN. Epidemiology, Clinical Characteristics and Risk Factors of 148 Severe Pertussis Cases in Yunnan. Journal of Kunming Medical University, 2022, 43(8): 145-149. doi: 10.12259/j.issn.2095-610X.S20220824
[6]	Bo TIAN, Yinzhong SHEN, Jinsong BAI, Jun LIU, Haiyun CHEN, Jianjun SUN. Clinical Characteristics of Talaromyces Marneffei Disease and Disseminated Nontuberculosis Mycobacterium Disease in AIDS Patients. Journal of Kunming Medical University, 2022, 43(7): 140-144. doi: 10.12259/j.issn.2095-610X.S20220718
[7]	Weimin LU, Xiaotao YANG, Ying ZHU, Yi HUANG, Houyu CHEN, Haifeng JIN, Yanchun WANG. Clinical Features and Risk Factors for Critical Cases of Scrub Typhus in 175 Children. Journal of Kunming Medical University, 2022, 43(8): 72-80. doi: 10.12259/j.issn.2095-610X.S20220814
[8]	Yong-ji FU, Fei PENG, Mei GUO, Hua YAN, Qing-cheng SHEN, Jin-xi BAI, Liu YANG. Clinical Characteristics of Gastric Cancer in Young Patients: A Retrospective Cohort Study. Journal of Kunming Medical University, 2021, 42(5): 81-86. doi: 10.12259/j.issn.2095-610X.S20210515
[9]	Hui-bo YANG, Qin MIAO, De-liang LIU, Si-si LI. Clinical Study on Characteristics of Kawasaki Disease in Yunnan Province. Journal of Kunming Medical University, 2020, 41(11): 103-108. doi: 10.12259/j.issn.2095-610X.S20201121
[10]	He Ying Chun , Li Mei Lan , Dong Yun Hua , Fan Hong Ping . . Journal of Kunming Medical University, 2019, 40(04): 11-15.
[11]	Shen Wen . Analysis of Clinical Characteristics and Misdiagnosis of 178 Patients with Pulmonary Embolism. Journal of Kunming Medical University,
[12]	Li Yan Ping . The Clinical Characteristics of Patients with Chronic Heart Failure with Preserved Ejection Fraction. Journal of Kunming Medical University,
[13]	Bai Run Ai . . Journal of Kunming Medical University,
[14]	Li Xiao Fei . The Influence of the Integrated Traditional Chinese and Western Medicine Treatment on Serum Levels of TNF-α， IL-6 and Endotoxin of Patients with Hepatic Failure. Journal of Kunming Medical University,
[15]	Li Jian . Clinical Significance of 5 Infectious Indicators for Patients with Knee Infection. Journal of Kunming Medical University,
[16]	A Yong Jun . . Journal of Kunming Medical University,
[17]	Liu Mei . Analysis on Genetic Characteristics of the Nonstructural Protein NSP4 of Human Rotavirus Strains in Infants with Diarrher in 2007 and 2008 in Kunming. Journal of Kunming Medical University,
[18]	Li Xian Li . . Journal of Kunming Medical University,
[19]	. Clinical Observation of Therapeutic Effects of Baibeining on Rotavirus Enteritis. Journal of Kunming Medical University,
[20]	Li Ke Rong . Clinical Treatment of 15 Patients with Gastroparesis after Major Abdominal Surgery. Journal of Kunming Medical University,

Supplements(0)

Cited By

Cited by

Periodical cited type(22)

1.	李雅静，于华. 机械振动排痰辅助治疗小儿肺炎的临床效果. 妇儿健康导刊. 2024(02): 59-61 .
2.	张艳梅. 机械排痰辅助药物治疗对小儿肺炎患儿排痰量及不良反应的影响. 现代医学与健康研究电子杂志. 2024(03): 142-144 .
3.	万娟，刘慧珍，刘路，刘攀，廖青慧. 机械振动排痰在支气管肺炎患儿中的应用. 中国医学创新. 2024(10): 75-79 .
4.	鲁金，周玲. 机械振动排痰应用于支气管肺炎患儿的临床疗效分析. 长治医学院学报. 2024(04): 282-284+288 .
5.	刘妹. 电动牙刷按摩肺俞穴在极低出生体重早产儿振动排痰中的应用. 黑龙江中医药. 2024(02): 26-28 .
6.	林阿蝉，林小娟. 机械振动辅助排痰联合童趣化干预对支气管肺炎患儿肺功能及舒适度的影响. 医疗装备. 2024(16): 149-151+155 .
7.	陈宝兰，缪建平，谌帆，赖玉婷. 鼻负压置换联合机械辅助排痰氧气雾化治疗小儿肺炎的临床研究. 医学信息. 2024(22): 38-41 .
8.	张国清，李薇，陈葵带. 肺部超声技术对新生儿肺部疾病的鉴别诊断价值研究. 中国医药科学. 2024(22): 68-71 .
9.	黄庆良，骆世明. 电动吸痰机联合全自动洗胃机在中毒患者急诊治疗期间的效果. 中国药物滥用防治杂志. 2024(12): 2232-2234 .
10.	钱海霞，马卉. 改良式拍背吸痰法在肺炎患儿雾化治疗中的应用效果. 当代护士(上旬刊). 2023(05): 102-105 .
11.	朱琰，殷晶，刘庭姣，施妤. 机械振动排痰仪辅助排痰联合头低足高俯卧位通气在社区获得性肺炎患儿中的应用. 齐鲁护理杂志. 2023(17): 165-167 .
12.	徐瑶瑶，郑芳明，江海霞. 机械振动排痰辅助雾化吸入治疗小儿肺炎对患儿临床症状的影响. 中国当代医药. 2023(24): 89-92 .
13.	尹丽娟，宝凌云，王芳，袁媛. 肺脏超声动态监测在新生儿重症肺炎精准护理中的应用效果. 昆明医科大学学报. 2023(10): 202-206 . 本站查看
14.	周冉冉，蒲海波，王媛. 无创吸痰结合乙酰半胱氨酸治疗小儿支气管肺炎的效果分析. 国际医药卫生导报. 2023(19): 2688-2692 .
15.	管辉琴，周丽玲. 多频振动治疗仪联合分期运动在小儿支气管肺炎护理中康复效果的观察. 中国医学创新. 2023(30): 105-110 .
16.	黄少波，王新玲. 维生素D治疗新生儿感染性肺炎的效果及其对TLR2的影响. 中外医学研究. 2023(35): 138-141 .
17.	肖诗兰，唐帆. 感染性肺炎新生儿肺部超声的临床护理实践. 现代医用影像学. 2023(12): 2373-2376 .
18.	张晓丽. 乙酰半胱氨酸肺泡灌洗术联合振动排痰仪对肺不张患儿临床症状及血气分析的影响. 反射疗法与康复医学. 2022(10): 97-99 .
19.	何莲，陈佩娟，李丹，邓婵媛. 振动型肿瘤患者护理用排痰器设计. 自动化与仪器仪表. 2022(07): 325-328+333 .
20.	汤琼，华翠红. 机械振动排痰联合体位引流在新生儿肺炎气道护理中的应用效果. 医疗装备. 2022(20): 156-158 .
21.	吴静娴，王君琴. 无创吸痰技术在支气管肺炎护理中应用的效果及安全性. 中国医药导报. 2022(32): 176-179 .
22.	肖民. 机械振动排痰仪联合综合护理在肺炎患儿中的应用效果. 医疗装备. 2022(24): 188-190 .