Comparison of Serum PCT, IL-6, SAA Levels and Clinical Characteristics between Rotavirus and Norovirus Enteritis in Children

Zhiying LU; Meifen WANG; Junchao PENG; Zengqing DU; Yunjiao LUO; Wei MA

doi:10.12259/j.issn.2095-610X.S20220823

Volume 43 Issue 8

Jul. 2022

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Zhiying LU, Meifen WANG, Junchao PENG, Zengqing DU, Yunjiao LUO, Wei MA. Comparison of Serum PCT, IL-6, SAA Levels and Clinical Characteristics between Rotavirus and Norovirus Enteritis in Children[J]. Journal of Kunming Medical University, 2022, 43(8): 138-144. doi: 10.12259/j.issn.2095-610X.S20220823

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Comparison of Serum PCT, IL-6, SAA Levels and Clinical Characteristics between Rotavirus and Norovirus Enteritis in Children

doi: 10.12259/j.issn.2095-610X.S20220823

Dept. of Infectious Diseases，Kunming Children’s Hospital，Yunnan Kunming 650028，China

Received Date: 2022-02-10
Publish Date: 2022-08-25

Abstract

Abstract

Objective To investigate the changes in serum PCT, IL-6, SAA levels and clinical characteristics of pediatric rotavirus （RV） and norovirus （NV） enteritis, and to analyze the factors for distinguishing the two. Methods In a prospective observational study, we selected children with watery diarrhea and diagnosed viral enteritis who were admitted to the Department of Infectious Diseases of Kunming Children’s Hospital from November 2019 to January 2021 as the research objects. Stool and venous blood samples were collected within 24 hours after admission for detection of fecal rotavirus and norovirus and determination of blood cells, serum procalcitonin （PCT）, interleukin-6 （IL-6） and serum amyloid A （SAA）. The gender, age, the most vomiting and diarrhea times within 24 h, complications, maximum BT, Vesikari score and other clinical characteristics of the children were analyzed by multivariate logistic regression and the accuracy of the model was assessed by ROC. Results 143 children were eligible, among which 76 were RV and 67 were NV. The maximum BT, the highest number of diarrhea within 24 hours, Vesikari score, neutrophil count （NEUT）, SAA, and the number of patients with body temperature > 38 ℃ were significantly higher in the RV group than those in the NV group （ P < 0.05）; There were no statistically significant differences in gender, age, the maximum number of vomiting at 24 h, complications, the number of people with Vesikari score ≥11, white blood cell count （WBC）, PCT, CRP, and IL-6 levels （ P > 0.05）. Multivariate logistic regression analysis showed that maximum BT, NEUT, and SAA were independent factors that distinguished the two. ROC was used to assess the accuracy of the model, and its AUC was 0.838 （95%CI: 0.770-0.907, P < 0.001）, maximum approximate den index （J = 0.573）, sensitivity was 83.6%, specificity was 73.7%. Conclusion RV enteritis causes more patients with higher fever （ > 38 ℃）, and there are more frequent diarrhea within 24 hours, which is more serious than NV enteritis. A model containing maximum BT, NEUT and SAA can assist pediatricians in differential diagnosis of infection by unknown pathogens.
- Rotavirus,
- Norovirus,
- Enteritis,
- PCT,
- IL-6,
- SAA,
- Clinical features

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References(20)

References

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