Advances on Smad4 on Olfactory System Function and Disease

Qie ZHANG; Shufen WANG; Shouming CAO; Haiying WU

doi:10.12259/j.issn.2095-610X.S20220826

Volume 43 Issue 8

Jul. 2022

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2022 > 43(8): 161-165

Qie ZHANG, Shufen WANG, Shouming CAO, Haiying WU. Advances on Smad4 on Olfactory System Function and Disease[J]. Journal of Kunming Medical University, 2022, 43(8): 161-165. doi: 10.12259/j.issn.2095-610X.S20220826

Citation:

Qie ZHANG, Shufen WANG, Shouming CAO, Haiying WU. Advances on Smad4 on Olfactory System Function and Disease[J]. Journal of Kunming Medical University, 2022, 43(8): 161-165. doi: 10.12259/j.issn.2095-610X.S20220826

Citation:

PDF( 600 KB)

Advances on Smad4 on Olfactory System Function and Disease

doi: 10.12259/j.issn.2095-610X.S20220826

1.
Dept .of Otorhinolaryngology, The 2nd Affiliated Hospital of Kunming Medical University, Kunming Yunnan 650101
2.
Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Biomedical Engineering Research Center, Kunming Medical University, Kunming Yunnan 650500, China

Received Date: 2022-01-10
Available Online: 2022-07-21
Publish Date: 2022-07-28

Abstract

Abstract

Smad4 protein binds to the TGF-β type I receptor（TβR I） on transforming growth factor-β（TGF-β） and activates it. The TGF-β/Smads signaling pathway is known to play a key role in the maturation, function, and precise connectivity of vomeronasal sensory neurons（VSNs）. Mutations in Smad4 lead to abnormal formation of the posterior paraolfactory bulb, resulting in abnormal olfactory conduction. Smad4 is a recognized tumor suppressor gene, and its expression in malignant tumors is significantly different from normal tissues. TGF-β transmits biological signals from the cell membrane to the nucleus through its signal transduction pathway and its substrate Smads protein to activate transcription of nucleic acid; consequently, to regulate cell differentiation, proliferation, adhesion, migration, apoptosis, angiogenesis, and immune response.
- Smad4,
- Olfactory system,
- Nasal tumor,
- Pheromones

FullText(HTML)

References(39)

References

[1]	姚方姝,陈科璞,周雯. 嗅觉新探索[J]. 科学世界,2019,20(5):100-105.
[2]	范晓清,杨铭. Smad4与胃癌关系的研究进展[J]. 当代医药论丛,2017,15(22):35-36. doi: 10.3969/j.issn.2095-7629.2017.22.022
[3]	Beltrán-Corbellini á,Chico-García JL,Martínez-Poles J,et al. Acute-onset smell and taste disorders in the context of COVID-19:A pilot multicentre polymerase chain reaction based case-control study[J]. Eur J Neurol,2020,27(9):1738. doi: 10.1111/ene.14273
[4]	Naik A S,Lin J M,Taroc E Z M,et al. Smad4 signaling establishes the somatosensory map of basal vomeronasal sensory neurons[J]. BioRxiv,2019,1(9):738393.
[5]	S Firestein. How the olfactory system makes sense of scents[J]. Nature,2001,413(6852):211-218. doi: 10.1038/35093026
[6]	Lapid H,Hummel T. Recording odor-evoked response potential at the human olfactory epithelium[J]. ChemSenses,2013,3(1):3-17.
[7]	Lin D Y,Zhang S Z,Block E,et a1. Encoding social signals in the mouse main olfactory bulb[J]. Nature,2005,434(3):470-477.
[8]	Brennan P A,Zufall F. Pheromonal communication in vertebrates[J]. Nature,2006,444(11):308-315.
[9]	Monti Bloch L,Grosser B I. Effect of putative pheromones on the electrical activity of the human vomeronasal organ and olfactory epithelium[J]. J Steroid Biochem Mol Biol,1991,39(4):573-582. doi: 10.1016/0960-0760(91)90255-4
[10]	Gower D B,Ruparelia B A. Olfaction in humans with special reference to odorous 16-androstenes:Their occurrence,perception and possible social,psychological and sexual impact[J]. J Endocrinol,1993,137(2):167-187. doi: 10.1677/joe.0.1370167
[11]	Thysen B,Elliott W H,Katzman P A. Identification of estra-l,3,5(10),16-tetraen-3-ol(estratetraenol)from the urine of pregnant women(1)[J]. Steroids,1968,11(1):73-87. doi: 10.1016/S0039-128X(68)80052-2
[12]	Wyart C,Webster W W,Chen J H,et al. Smelling a single component of male sweat alters levels of cortisol in women[J]. J Neurosci,2007,27(6):1261-1265. doi: 10.1523/JNEUROSCI.4430-06.2007
[13]	Lundstrom J N, Olsson M J. Subthreshold amounts of social odorant affect mood, but not behavior, in heterosexual women when tested by a male, but not a female, experimenter[J]. Biol Psychol, 2005, 70（3）: l 97-204.
[14]	Bensafi M,Brown W M,Tsutsui T,et a1. Sex-steroid derived compounds induce sex—specific effects on autonomic nervous system function in humans[J]. Behav Neurosci,2003,117(6):1125-1134. doi: 10.1037/0735-7044.117.6.1125
[15]	Grosser B I,Monti Bloch L,Jennings White C,et a1. Behavioral and electrophysiological effects of androstadienone,a humanpheromone[J]. Psychoneuroendocrinology,2000,25(3):289-299. doi: 10.1016/S0306-4530(99)00056-6
[16]	吴民耀,张凡,王宏元. 犁鼻器的结构和功能[J]. 动物医学进展,2012,33(01):111-114. doi: 10.3969/j.issn.1007-5038.2012.01.025
[17]	Zhao M,Mishra L,Deng C X. The role of TGF-β/SMAD4 signaling in cancer[J]. Int J Biol Sci,2018,14(2):111-123. doi: 10.7150/ijbs.23230
[18]	侯雪飞,杨铮,万崇华,等. 大肠癌患者报告结局、生命质量与基因关系的初步探讨[J]. 广东医科大学学报,2020,37(5):543-546,552. doi: 10.3969/j.issn.1005-4057.2020.05.007
[19]	A Rodewald,D Gisder,V M Gebhart,et al. Distribution of olfactory marker protein in the rat vomeronasal organ[J]. Journal of Chemical Neuroanatomy,2016,77(5):19-23.
[20]	Naik Ankana S,Lin Jennifer M,Taroc E d Zandro M,et al. Smad4-dependent morphogenic signals control the maturation and axonal targeting of basal vomeronasal sensory neurons to the accessory olfactory bulb.[J]. Development (Cambridge,England),2020,147(8):184036.
[21]	Noguchi Tomohiro,Miyazono Sadaharu,Kashiwayanagi Makoto. Stimulus dynamics-dependent information transfer of olfactory and vomeronasal sensory neurons in mice.[J]. Neuroscience,2018,4(12):5.
[22]	Chen K,Ye Y,Troje N F,et al. Oxytocin modulates human chemosensory decoding of sex in a dose-dependent manner[J]. ELife,2021,10(1):59376. doi: 10.7554/eLife.59376
[23]	叶玉婷,陈科璞,周雯. 信息素影响人类行为吗?[J]. 科学通报,2016,61(13):1389-1394.
[24]	Pause B M,Ohrt A,Prehn A,et a1. Positive emotional priming of facial affect perception in females is diminished by chemosensory anxiety signals[J]. Chem Senses,2004,29(9):797-805. doi: 10.1093/chemse/bjh245
[25]	Prehn A,Ohrt A,Sojka B,et a1. Chemosensory anxiety signals augment the startle reflex in humans[J]. Neurosci Lett,2006,394(2):127-130. doi: 10.1016/j.neulet.2005.10.012
[26]	Zhou W. Chen D. Fear-related chemosignals modulate recognition of fear in ambiguous facial expressions[J]. Psychol Sci,2009,20:177-183. doi: 10.1111/j.1467-9280.2009.02263.x
[27]	De Groot J H,Smeets M A,Kaldewaij A,et a1. Chemosignals communicate human emotions[J]. Psychol Sci,2012,23(11):1417-1424. doi: 10.1177/0956797612445317
[28]	Parma V,Tirindelli R,Bisazza A,et a1. Subliminally perceived odours modulate female intrasexual competition:An eye movement study[J]. PLoS One,2012,7(2):30645. doi: 10.1371/journal.pone.0030645
[29]	Gelstein S,Yeshurun Y,Rozenkrantz L,et a1. Human tears contain a chemosignal[J]. Science,2011,331(6014):226-230. doi: 10.1126/science.1198331
[30]	Sarah M,Joshua J,Sean K,et al. Smad4 loss promotesung cancer formation but increases sensitivity to DNA topoisomerase inhibitors[J]. Oncogene,2016,35(5):577-586. doi: 10.1038/onc.2015.112
[31]	Demagny H,De Robertis E M. Point mutations in the tumor suppressor Smad4/DPC4 enhance its phosphorylation by GSK3 and reversibly inactivate TGF-beta signaling[J]. Mol Cell Oncol,2016,3(1):1025181. doi: 10.1080/23723556.2015.1025181
[32]	方凌凌. LAMC1及PLAU调控微环境中CAF的活化及促进食管鳞癌进展的机制研究[D]. 北京: 北京协和医院博士学位论文, 2021.
[33]	陈海燕, 郝敏, 王志莲. Smad4与女性生殖系统恶性肿瘤关系的研究进展[J/CD]. 中华妇幼临床医学杂志, 2016, 12（3）: 349-353.
[34]	Mackenzie R,Kommoss S,Winterhoff B J,et al. Targeted deep sequencing of mucinous ovarian tumors reveals multiple overlapping AS pathway activating mutations in borderline and cancerous neoplasms[J]. BMC Cancer,2015,15(5):415.
[35]	V á zquez P F,Carlini M J,Daroqui M C,et al. TGF-β specifically enhances the metastatic attributes of murine lung adenocarcinoma:implications for human non-small cell lung cancer[J]. Clin Exp Metastasis,2013,30(8):993-1007. doi: 10.1007/s10585-013-9598-1
[36]	Lei Z,Xu G,Wang L,et al. MiR-142-3p represses TGF-β-induced growth inhibition through repression of TGFβR1 in non-small cell lung cancer[J]. FASEB J,2014,28(6):2696-2704. doi: 10.1096/fj.13-247288
[37]	刘剑锋,杨大章. 鼻-鼻颅底恶性肿瘤的治疗进展[J]. 中国耳鼻咽喉颅底外科杂志,2017,23(6):501-508.
[38]	吴林林,刘红刚. 嗅神经母细胞瘤临床病理特征与治疗的研究进展[J]. 诊断病理学杂志,2021,28(2):124-127. doi: 10.3969/j.issn.1007-8096.2021.02.011
[39]	Topcagic J,Feldman R,Ghazalpour A,et al. Comprehensive molecular profiling of advanced/metastatic olfactory neuroblastomas[J]. PLoS One,2018,13(1):191,244.

Relative Articles(20)

Relative Articles

[1]	Li MA, Yu'e ZHOU, Jiahui JIANG, Junyao LI, Xiaoyan MU, Yi MA. Effect of Olfactory Comfort Combined with Maternal Voice Stimulation on Sleep in Hospitalized Preterm Infants. Journal of Kunming Medical University, 2024, 45(8): 188-192. doi: 10.12259/j.issn.2095-610X.S20240827
[2]	Min YANG, Qiqi LIN, Dandan LIU, Hongyu ZHOU. Research Progress on the Anti-tumor Activity and Mechanism of Narciclasine. Journal of Kunming Medical University, 2024, 45(2): 153-159. doi: 10.12259/j.issn.2095-610X.S20240222
[3]	Shiyao YANG, Yanxia YANG, Haiyin YANG, Yong DONG, Jinhu MIAO, Yuexi ZHU, Qiongyao GUAN. A Systematic Evaluation of Incidence and Influencing Factors of Falls in Adult Cancer Patients. Journal of Kunming Medical University, 2024, 45(12): 1-10.
[4]	Yu LV, Yibo HU, Jiaxin WANG, Youtong SU, Youguo DAI. Advances on the Relationship between Protein S-nitrosylation and Digestive System Tumors. Journal of Kunming Medical University, 2022, 43(9): 155-159. doi: 10.12259/j.issn.2095-610X.S20220911
[5]	Zi-hong CHEN, Hong LIU, Ming-wei LIU, Mi SHU, Qiong NAN. Research Progress of miRNA-145 in Malignant Tumors of Digestive System. Journal of Kunming Medical University, 2021, 42(3): 145-148. doi: 10.12259/j.issn.2095-610X.S20210334
[6]	Chen Peng , Yang Xi Jun , Li Chun Man , Liu Feng , A Yong Jun . Influence of Quercetin on the Recurrence of Tumor After Liver Cancer Resection in Athymic Mice and its Mechanism. Journal of Kunming Medical University, 2017, 38(11): 25-28.
[7]	Wang Chun Long , Han Dan , Wen Liang . Research Progress of Mesothelin in Tumor Diagnosis and Treatment. Journal of Kunming Medical University, 2017, 38(09): 134-139.
[8]	Zhao Xiao Lin . The Effects of Endocannabinoid System on Alcohol-induced Liver Cell Injury. Journal of Kunming Medical University,
[9]	Liao Ran Chao . . Journal of Kunming Medical University,
[10]	Jiang Chao Wu . . Journal of Kunming Medical University,
[11]	Du Xing Hua . . Journal of Kunming Medical University,
[12]	Liu Jian Jun . . Journal of Kunming Medical University,
[13]	Li Rui . . Journal of Kunming Medical University,
[14]	Yang Li Hua . . Journal of Kunming Medical University,
[15]	Li Yu Xiao . . Journal of Kunming Medical University,
[16]	Sun Tao . . Journal of Kunming Medical University,
[17]	Ma Yun . The Life Quality of Policemen in Kunming and Its Influencing Factors. Journal of Kunming Medical University,
[18]	Jie Yan Hua . Chest X-ray Radiographic and CT Findings in Severe A (H1N1)Virus Infection. Journal of Kunming Medical University,
[19]	. Effect of Deep Hypothermic Circulatory Arrest on Expression of Smad2 and Smad4 in Cortex Neuron of Rats. Journal of Kunming Medical University,
[20]	Deng De Yao . . Journal of Kunming Medical University,