Volume 43 Issue 8
Jul.  2022
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Article Navigation >  Journal of Kunming Medical University  > 2022  >  43(8): 161-165
Jiping ZHOU, Junling ZHANG, Qing LIU, Xingmei LI, Peiyou FAN, Heling JIANG. The Application of “Modular Teaching Method” in the Nursing Teaching of Nephrology Department[J]. Journal of Kunming Medical University, 2022, 43(5): 168-172. doi: 10.12259/j.issn.2095-610X.S20220523
Citation: Qie ZHANG, Shufen WANG, Shouming CAO, Haiying WU. Advances on Smad4 on Olfactory System Function and Disease[J]. Journal of Kunming Medical University, 2022, 43(8): 161-165. doi: 10.12259/j.issn.2095-610X.S20220826
shu

Advances on Smad4 on Olfactory System Function and Disease

doi: 10.12259/j.issn.2095-610X.S20220826
  • 1.

    Dept .of Otorhinolaryngology, The 2nd Affiliated Hospital of Kunming Medical University, Kunming Yunnan 650101

  • 2.

    Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Biomedical Engineering Research Center, Kunming Medical University, Kunming Yunnan 650500, China

  • Received Date: 2022-01-10
    Available Online: 2022-07-21
  • Publish Date: 2022-07-28
    Abstract
  • Smad4 protein binds to the TGF-β type I receptor（TβR I） on transforming growth factor-β（TGF-β） and activates it. The TGF-β/Smads signaling pathway is known to play a key role in the maturation, function, and precise connectivity of vomeronasal sensory neurons（VSNs）. Mutations in Smad4 lead to abnormal formation of the posterior paraolfactory bulb, resulting in abnormal olfactory conduction. Smad4 is a recognized tumor suppressor gene, and its expression in malignant tumors is significantly different from normal tissues. TGF-β transmits biological signals from the cell membrane to the nucleus through its signal transduction pathway and its substrate Smads protein to activate transcription of nucleic acid; consequently, to regulate cell differentiation, proliferation, adhesion, migration, apoptosis, angiogenesis, and immune response.
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