Volume 43 Issue 8
Jul.  2022
Turn off MathJax
Article Contents
Hanqing ZHAO, Shibing QIAN, Mengqi WANG, Rongyu YANG, Kaiwen DUAN. Oral Lesions Associated with 2019-nCoV[J]. Journal of Kunming Medical University, 2022, 43(8): 156-160. doi: 10.12259/j.issn.2095-610X.S20220831
Citation: Hanqing ZHAO, Shibing QIAN, Mengqi WANG, Rongyu YANG, Kaiwen DUAN. Oral Lesions Associated with 2019-nCoV[J]. Journal of Kunming Medical University, 2022, 43(8): 156-160. doi: 10.12259/j.issn.2095-610X.S20220831

Oral Lesions Associated with 2019-nCoV

doi: 10.12259/j.issn.2095-610X.S20220831
  • Received Date: 2022-02-26
    Available Online: 2022-03-15
  • Publish Date: 2022-07-28
  • COVID-19 virus is the pathogen of the new type of corona virus disease 2019, a global infectious disease that began to spread at the end of 2019. It has caused damage to multiple organs particularly human respiratory tract. Oral lesions is considered to be a common manifestation of this disease. This article summarized the characteristics and possible mechanisms of COVID-19 related oral damage in novel coronavirus infections and oral manifestations from publications between December 2019 and November 2021. It showed that the oral manifestations of the reported cases were mainly gustatory dysfunction, xerostomia and ulcerative lesions. The mechanism of oral lesions is not yet fully understood, but 2019-nCoV enters the cell receptor ACE2 widely in oral epithelial cells. Virus replication and possible tissue inflammation and destruction could be its possible pathogenic mechanisms.
  • loading
  • [1]
    王业明,徐逸天,曹彬. 新型冠状病毒感染传播、发病机制、诊断和治疗的进展[J]. 中华结核和呼吸杂志,2021,44(7):684-688. doi: 10.3760/cma.j.cn112147-20201120-01106
    [2]
    Lu R,Zhao X,Li J,et al. Genomic characterisation and epidemiology of 2019 novel coronavirus:Implications for virus origins and receptor binding[J]. Lancet Lond Engl,2020,3959(3):565-574.
    [3]
    Chen L,Zhao J,Peng J,et al. Detection of SARS-CoV-2 in saliva and characterization of oral symptoms in COVID-19 patients[J]. Cell Prolif,2020,53(12):12923.
    [4]
    Hindson J. COVID-19:Faecal–oral transmission?[J]. Nature Reviews Gastroenterology &Hepatology,2020,17(5):259.
    [5]
    To K K,Tsang O T,YipC C,et al. Consistent detection of 2019 novel coronavirus in saliva[J]. Clin Infect Dis,2020,71(5):841-843.
    [6]
    Xu H,Zhong L,Deng J,et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa[J]. Int J Oral Sci,2020,12(1):8. doi: 10.1038/s41368-020-0074-x
    [7]
    Tay M Z,Poh C M,Rea L,et al. The trinity of COVID‐19:immunity,inflammation and intervention[J]. Nat Rev Immunol,2020,20(6):363-374.
    [8]
    Sapkota D,Søland T M,Galtung H K,et al. COVID-19 salivary signature:Diagnostic and research opportunities[J]. J Clin Pathol,2020,74(6):344-349.
    [9]
    Santos J A,Normando A G C,Carvalho da Silva R L,et al. Oral mucosal lesions ina COVID‐19 patient:New signs or secondary manifestations?[J]. Int J Infect Dis,2020,97(2):326-328.
    [10]
    Mullol J,Alobid I,Marino-Sanchez F,et al. The loss of smell and taste in the COVID-19 outbreak:A tale of many countries[J]. Curr Allergy Asthma Rep,2020,20(10):61. doi: 10.1007/s11882-020-00961-1
    [11]
    Benazzo M,Cassaniti I,Maiorano E,et al. SARS‐CoV‐2 virologic and immunologic correlates in patients with olfactory and taste disorders[J]. Microorganisms,2020,8(7):1052. doi: 10.3390/microorganisms8071052
    [12]
    MarinoSanchez F,SantamariaGadea A,De Los Santos G,et al. Psychophysical olfactory testing in COVID-19:Is smell function really impaired in nearly all patients?[J]. Int Forum Allergy Rhinol,2020,10(8):951-952.
    [13]
    Sakaguchi W,Kubota N,Shimizu T,et al. Existence of SARS-CoV-2 entry molecules in the oral cavity[J]. Int J Mol Sci,2020,21(17):6000. doi: 10.3390/ijms21176000
    [14]
    Finsterer J,Stollberger C. Causes of hypogeusia/hyposmia in SARS-CoV2 infected patients[J]. J Med Virol,2020,92(12):1793-1794.
    [15]
    Jothimani D,Kailasam E,Danielraj S,et al. COVID-19:Poor outcomes in patients with zinc deficiency[J]. Int J Infect Dis,2020,100(3):343-349.
    [16]
    Favia G,Tempesta A,Barile G,et al. Covid-19 symptomatic patients with oral lesions:Clinical and histopathological study on 123 cases of the university hospital policlinic of bari with a purpose of a new classification[J]. J Clin Med,2021,10(4):757. doi: 10.3390/jcm10040757
    [17]
    Gherlone E F,Polizzi E,Tete G,et al. Frequent and persistent salivary gland ectasia and oral disease after COVID-19[J]. J Dent Res,2021,100(5):464-471. doi: 10.1177/0022034521997112
    [18]
    Farshidfar N, Hamedani S. Hyposalivation as a potential risk for SARS-CoV-2 infection: Inhibitory role of saliva[J]. Oral Dis, 2020, 27(Suppl 3): 750-751.
    [19]
    Biadsee A,Kassem F,Dagan O,et al. Olfactory and oral manifestations of COVID-19:Sex-related symptoms-A potential pathway to early diagnosis[J]. Otolaryngol Head Neck Surg,2020,163(4):722-728. doi: 10.1177/0194599820934380
    [20]
    Hockova B,Riad A,Valky J,et al. Oral Complications of ICU patients with COVID-19:Case-series and review of two hundred tencases[J]. J Clin Med,2021,10(4):581. doi: 10.3390/jcm10040581
    [21]
    Iranmanesh B,Khalili M,Amiri R,et al. Oral manifestations of COVID-19 disease:A review article[J]. Dermatol Ther,2021,34(1):14578.
    [22]
    Riad A,Gomaa E,Hockova B,et al. Oral candidiasis of COVID-19 patients:Case report and review of evidence[J]. J CosmetDermatol,2021,20(6):1580-1584.
    [23]
    Le Balch P,Pinceaux K,Pronier C,et al. Herpes simplex virus and cytomegalovirus reactivations among severe COVID-19 patients[J]. Crit Care,2020,24(1):530. doi: 10.1186/s13054-020-03252-3
    [24]
    Burgos Ponce J, Trijoe K C. Overlapping findings or oral manifestations in new SARS- CoV-2 infection[J]. Oral Dis, 2020 , 27 (Suppl 3): 781-782.
    [25]
    Patel J, Woolley J. Necrotizing periodontal disease: Oral manifestation of COVID‐19[J]. Oral Dis, 2021, 27 (Suppl 3): 768-769.
    [26]
    Anand P S,Jadhav P,Kamath K P,et al. A case-control study on the association between periodontitis and coronavirus disease (COVID-19)[J]. J Periodontol,2021,18(1):1-7.
    [27]
    Halepas S,Lee K C,Myers A,et al. Oral manifestations of COVID-2019-related multisystem inflammatory syndrome in children:A review of 47 pediatric patients[J]. J Am Dent Assoc,2021,152(3):202-208. doi: 10.1016/j.adaj.2020.11.014
  • Relative Articles

    [1] Songqin LYU, Shan HUANG, Litang MA, Xiu WANG, Hongtao ZHANG, Qin LI, Chunping WAN, Zhengchao LYU. The Investigation and Analysis of the Situation of COVID-19 Vaccination and Vaccination Willingness in HIV/AIDS Population in Yunnan Province. Journal of Kunming Medical University, 2024, 45(1): 48-54.  doi: 10.12259/j.issn.2095-610X.S20240108
    [2] Haiping HE. Analysis of Coagulation Function Indexes in Elderly Patients with Novel Coronavirus Pneumonia. Journal of Kunming Medical University, 2024, 45(4): 99-104.  doi: 10.12259/j.issn.2095-610X.S20240414
    [3] Ying HUANG, Yun LUO, Yan WU, Bing LIU, Shan JIANG, Hua HE. The Regularity and Clinical Manifestations of Throat Swab and Fecal Detoxification in New Coronavirus Infected Patients. Journal of Kunming Medical University, 2022, 43(1): 96-101.  doi: 10.12259/j.issn.2095-610X.S20220112
    [4] Fang WANG, Rong ZHAO, Hong ZHENG. Clinical Effect of Kan Fu Xin Combined with Montmorillonite on the Prevention and Treatment of Radiation-induced Oral Mucositis in Patients with Head and Neck Cancer. Journal of Kunming Medical University, 2021, 42(6): 98-102.  doi: 10.12259/j.issn.2095-610X.S20210626
    [5] Shun-hui YIN, Jian-zhong ZHOU, Zi-liang LI. Tiger17 Promotes the Proliferation and Migration of Human Oral Mucosa Fibroblast Cells. Journal of Kunming Medical University, 2021, 42(8): 128-131.  doi: 10.12259/j.issn.2095-610X.S20210823
    [6] Ting-ting DUAN, Ya LV, Rui PAN, Li WANG, Ying TIAN. Effects of the Intensive Nursing Plan on Prevention of the Oral Mucositis Caused by Chemotherapy in Acute Leukemia. Journal of Kunming Medical University, 2021, 42(1): 167-172.  doi: 10.12259/j.issn.2095-610X.S20210108
    [7] Li WU, Yun-hui YANG, Jing ZHANG, Zhang-cong YANG, Yu SU, Yong-jian WEN, Yu-chun WU, Peng WANG, Zhi-peng LI, Wei ZHAO, Dan HAN, Rui-dong WANG, Bo HE. The Correlation between the Imaging Characteristics of Imported COVID-19 at First Diagnosis and Clinical Severity Grading. Journal of Kunming Medical University, 2021, 42(7): 49-56.  doi: 10.12259/j.issn.2095-610X.S20210708
    [8] Hui DING, Lan YAO. Periodontal Status and Its Influencing Factors in Rural Population aged 65-74 in Yunnan Province. Journal of Kunming Medical University, 2021, 42(4): 38-43.  doi: 10.12259/j.issn.2095-610X.S20210407
    [9] Yun-hui YANG, Bo HE, Ding-yun YOU, Jun-tao YANG, Qian GAO. Applications of CT in the Early Prediction of Different Clinical Types of COVID -19 Pneumonia. Journal of Kunming Medical University, 2021, 42(5): 131-137.  doi: 10.12259/j.issn.2095-610X.S20210524
    [10] Si-si PENG, Hui DING, Li-ya MA, Yang LV, Yan-hao DUAN, Lei YANG, Shi-nan ZHANG. Oral Health Status of Undergraduate Students in Kunming City. Journal of Kunming Medical University, 2021, 42(6): 62-66.  doi: 10.12259/j.issn.2095-610X.S20210624
    [11] Huan LI, Qiu-yue XU, Yun-juan WANG, Yang SU, Rui-zhu TANG. The Rapid Detection of Nucleic Acid in SARS-CoV-2 by Reverse Transcription Loop Mediated Isothermal Amplification. Journal of Kunming Medical University, 2021, 42(9): 25-31.  doi: 10.12259/j.issn.2095-610X.S20210904
    [12] Wang Ya Zhou , Huang Qin , Li Xiao Ming , Zhang Du Fei , Wei Dao . . Journal of Kunming Medical University, 2020, 41(02): 87-90.
    [13] Gu Li Ming , Zeng Yong , Chen Jun Hui , Wang Fu Ping , Hao Ying Lu , Wu Hai Ying , Ruan Ji Yin , Li Yan Jiao , Chen Yun , Xia Jing , Sun Jia , Hu Juan Yuan , Li Wei , Yu Cong Tao , Ma Chao Xia , Qian Chuan Yun , Hu Min . . Journal of Kunming Medical University, 2020, 41(03): 96-100.
    [14] Ma Zhi Qiang , Wang Lin , Luo Yu , Qu Chun Yan , Li Bao Ping , Ma Yun Shan , Dong Rui , Wu Yan Rong , Zhao Jin Hua , Xu Ya Lin . . Journal of Kunming Medical University, 2020, 41(03): 128-131.
    [15] Ye Wen Jun , Wang Rui Hang , Zeng Xiao Ju , Liu Wei Qing , Liu Fang . . Journal of Kunming Medical University, 2020, 41(02): 137-140.
    [16] Yuan Yu , Li Xiang . . Journal of Kunming Medical University, 2020, 41(04): 1-5.
    [17] He Hong , Zhang Wan Li , Li Xing Xing , Niu Tao , Li Hong Yun . The Clinical Application of Fixed Permanent Periodontal Splint. Journal of Kunming Medical University, 2018, 39(01): 127-130.
    [18] Peng Yi . An Investigation on Oral Health Status of 480 Lahu People in Lincang,Yunnan. Journal of Kunming Medical University,
    [19] Shui Yan Qing . . Journal of Kunming Medical University, 2014, 35(11): 1-1.
    [20] Pu Dong . . Journal of Kunming Medical University,
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (3946) PDF downloads(29) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return