The Value of HCT-ALB in the Early Diagnosis of Sepsis-associated Encephalopathy

Congxin LI; Dapeng ZHANG; Lingjie MU; Jilin YANG; Lihong DONG; Yijie WANG

doi:10.12259/j.issn.2095-610X.S20220901

Volume 43 Issue 9

Sep. 2022

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Congxin LI, Dapeng ZHANG, Lingjie MU, Jilin YANG, Lihong DONG, Yijie WANG. The Value of HCT-ALB in the Early Diagnosis of Sepsis-associated Encephalopathy[J]. Journal of Kunming Medical University, 2022, 43(9): 24-28. doi: 10.12259/j.issn.2095-610X.S20220901

Citation:

Congxin LI, Dapeng ZHANG, Lingjie MU, Jilin YANG, Lihong DONG, Yijie WANG. The Value of HCT-ALB in the Early Diagnosis of Sepsis-associated Encephalopathy[J]. Journal of Kunming Medical University, 2022, 43(9): 24-28. doi: 10.12259/j.issn.2095-610X.S20220901

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The Value of HCT-ALB in the Early Diagnosis of Sepsis-associated Encephalopathy

doi: 10.12259/j.issn.2095-610X.S20220901

1.
Dept. of ICU，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan, 650032
2.
Kunming Meizhao Health Examination Center，Kunming Yunnan 650032，China

Received Date: 2022-07-26
Available Online: 2022-09-07
Publish Date: 2022-09-29

Abstract

Abstract

Objective To find simple and reliable clinical quantitative indicators for the early diagnosis of SAE. Methods Seventy-two septic patients who were admitted to ICU from April 2020 to April 2022, including 31 with sepsis encephalopathy （SAE） and 41 without sepsis encephalopathy （Ne-SAE）, were collected. APACHE Ⅱ, SOFA and general data of Patients were recorded, and CLI, HCT-ALB were calculated based on the clinical assays. Plasma was collected using ELISA to detect NT-proCNP, S100A 8, Tau protein and C5a. Results APACHEⅡscore and SOFA score in SAE group were significantly higher compared with the patients in Ne-SAE group （P < 0.05）. Plasma NT-proCNP and S100A8 levels were significantly higher in the patients with SAE than that of the Ne-SAE group （P < 0.05）. There was no significant difference in CLI between SAE group and NE-SAE group. （P = 0.823）. But , the hct-alb was statistically significant between the two groups （P = 0.035）. The roc curve analysis showed: A cutoff value CLI of 11.04 （AUC = 0.478,95% CI 0.340-0.616, P = 0.746） had 46.34% sensitivity and 80.65% specificity in diagnosing SAE. A cutoff value HCT-ALB of 14.85 （AUC = 0.627,95% CI 0.491-0.762, P = 0.017） had 68.27% sensitivity and 67.74% specificity in diagnosing SAE. Conclusion The HCT-ALB level can be useful in the early diagnosis of SAE in patients with sepsis.

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References(19)

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