Glucose Transport in Human Placenta and the Effect of GDM on Placental Glucose Transport

Yindong HE; Jun ZHANG; Hua HUANG; Ruming LIU; Xi WANG

doi:10.12259/j.issn.2095-610X.S20220903

Volume 43 Issue 9

Sep. 2022

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2022 > 43(9): 160-165

Yindong HE, Jun ZHANG, Hua HUANG, Ruming LIU, Xi WANG. Glucose Transport in Human Placenta and the Effect of GDM on Placental Glucose Transport[J]. Journal of Kunming Medical University, 2022, 43(9): 160-165. doi: 10.12259/j.issn.2095-610X.S20220903

Citation:

Yindong HE, Jun ZHANG, Hua HUANG, Ruming LIU, Xi WANG. Glucose Transport in Human Placenta and the Effect of GDM on Placental Glucose Transport[J]. Journal of Kunming Medical University, 2022, 43(9): 160-165. doi: 10.12259/j.issn.2095-610X.S20220903

Citation:

PDF( 608 KB)

Glucose Transport in Human Placenta and the Effect of GDM on Placental Glucose Transport

doi: 10.12259/j.issn.2095-610X.S20220903

Dept. of Clinical Medicine，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2022-06-09
Available Online: 2022-09-07
Publish Date: 2022-09-29

Abstract

Abstract

Placenta plays an important role in the process of glucose transfer from maternal to fetus. The normal structure and function of the placenta guarantee the fetus to take up glucose effectively from maternal side over the gestation. Glucose transplacental transfer mainly depends on the glucose transporters （GLUTs）. And the placenta and other factors such as placental glucose metabolic activity could also affect the glucose transplacental transfer. Gestational diabetes mellitus （GDM） is a main complication of pregnancy. Fetal adverse outcomes from GDM patients may be caused by the abnormality of glucose transport in the placenta. This review aims to discuss the glucose transplacental transfer on the normal placenta and summarize some changes and molecular mechanism that have been reported about glucose transplacental transfer in the GDM.
- Placenta,
- Glucose transport,
- Glucose transporters,
- GDM

FullText(HTML)

References(43)

References

[1]	Day P E,Cleal J K,Lofthouse E M,et al. What factors determine placental glucose transfer kinetics?[J]. Placenta,2013,34(10):953-958. doi: 10.1016/j.placenta.2013.07.001
[2]	Stanirowski P J,Szukiewicz D,Pyzlak M,et al. Impact of pre-gestational and gestational diabetes mellitus on the expression of glucose transporters GLUT-1,GLUT-4 and GLUT-9 in human term placenta[J]. Endocrine,2017,55(3):799-808. doi: 10.1007/s12020-016-1202-4
[3]	Illsley N P,Baumann M U. Human placental glucose transport in fetoplacental growth and metabolism[J]. Biochim Biophys Acta Mol Basis Dis,2020,1866(2):165-359.
[4]	Jansson T,Wennergren M,Illsley N P. Glucose transporter protein expression in human placenta throughout gestation and in intrauterine growth retardation[J]. J Clin Endocrinol Metab,1993,77(6):1554-1562.
[5]	Illsley N P. Placental glucose transport in diabetic pregnancy[J]. Clin Obstet Gynecol,2000,43(1):116-126. doi: 10.1097/00003081-200003000-00012
[6]	Vardhana P A,Illsley N P. Transepithelial glucose transport and metabolism in BeWo choriocarcinoma cells[J]. Placenta,2002,23(8-9):653-660. doi: 10.1053/plac.2002.0857
[7]	Brown K,Heller D S,Zamudio S,et al. Glucose transporter 3 (GLUT3) protein expression in human placenta across gestation[J]. Placenta,2011,32(12):1041-1049. doi: 10.1016/j.placenta.2011.09.014
[8]	Janzen C,Lei M Y,Cho J,et al. Placental glucose transporter 3 (GLUT3) is up-regulated in human pregnancies complicated by late-onset intrauterine growth restriction[J]. Placenta,2013,34(11):1072-1078. doi: 10.1016/j.placenta.2013.08.010
[9]	James-Allan L B,Arbet J,Teal S B,et al. Insulin stimulates GLUT4 trafficking to the syncytiotrophoblast basal plasma membrane in the human placenta[J]. J Clin Endocrinol Metab,2019,104(9):4225-4238. doi: 10.1210/jc.2018-02778
[10]	Ericsson A,Hamark B,Powell T L,et al. Glucose transporter isoform 4 is expressed in the syncytiotrophoblast of first trimester human placenta[J]. Hum Reprod,2005,20(2):521-530. doi: 10.1093/humrep/deh596
[11]	Hiden U,Glitzner E,Hartmann M,et al. Insulin and the IGF system in the human placenta of normal and diabetic pregnancies[J]. J Anat,2009,215(1):60-68. doi: 10.1111/j.1469-7580.2008.01035.x
[12]	Desoye G,Hartmann M,Blaschitz A,et al. Insulin receptors in syncytiotrophoblast and fetal endothelium of human placenta. Immunohistochemical evidence for developmental changes in distribution pattern[J]. Histochemistry,1994,101(4):277-285. doi: 10.1007/BF00315915
[13]	Augustin R,Carayannopoulos M O,Dowd L O,et al. Identification and characterization of human glucose transporter-like protein-9 (GLUT9):Alternative splicing alters trafficking[J]. J Biol Chem,2004,279(16):16229-16236. doi: 10.1074/jbc.M312226200
[14]	Gude N M,Stevenson J L,Rogers S,et al. GLUT12 expression in human placenta in first trimester and term[J]. Placenta,2003,24(5):566-570. doi: 10.1053/plac.2002.0925
[15]	Michelsen T M,Holme A M,Holm M B,et al. Uteroplacental glucose uptake and fetal glucose consumption:A quantitative study in human pregnancies[J]. J Clin Endocrinol Metab,2019,104(3):873-882. doi: 10.1210/jc.2018-01154
[16]	Hod M, Kapur A, Sacks D A, et al. The international federation of gynecology and obstetrics （FIGO） initiative on gestational diabetes mellitus: A pragmatic guide for diagnosis, management, and care [J]. Int J Gynaecol Obstet, 2015, 131（Suppl 3 ）: S173-211.
[17]	Wei Y,Yang H,Zhu W,et al. International association of diabetes and pregnancy study group criteria is suitable for gestational diabetes mellitus diagnosis:Further evidence from China[J]. Chin Med J (Engl),2014,127(20):3553-3556.
[18]	American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins-Obstetrics. Practice Bulletin No. 180:Gestational diabetes mellitus[J]. Obstet Gynecol,2017,130(1):e17-e37.
[19]	Dugas C,Perron J,Kearney M,et al. Postnatal prevention of childhood obesity in offspring prenatally exposed to gestational diabetes mellitus:Where are we now?[J]. Obes Facts,2017,10(4):396-406. doi: 10.1159/000477407
[20]	Ashfaq M,Janjua M Z,Channa M A. Effect of gestational diabetes and maternal hypertension on gross morphology of placenta[J]. J Ayub Med Coll Abbottabad,2005,17(1):44-47.
[21]	Desoye G,Cervar-Zivkovic M. Diabetes mellitus,obesity,and the placenta[J]. Obstet Gynecol Clin North Am,2020,47(1):65-79. doi: 10.1016/j.ogc.2019.11.001
[22]	Madazli R,Tuten A,Calay Z,et al. The incidence of placental abnormalities,maternal and cord plasma malondialdehyde and vascular endothelial growth factor levels in women with gestational diabetes mellitus and nondiabetic controls[J]. Gynecol Obstet Invest,2008,65(4):227-232. doi: 10.1159/000113045
[23]	Hahn T,Barth S,Weiss U,et al. Sustained hyperglycemia in vitro down-regulates the GLUT1 glucose transport system of cultured human term placental trophoblast:A mechanism to protect fetal development?[J]. Faseb J,1998,12(12):1221-1231. doi: 10.1096/fasebj.12.12.1221
[24]	Illsley N P,Sellers M C,Wright R L. Glycaemic regulation of glucose transporter expression and activity in the human placenta[J]. Placenta,1998,19(7):517-524. doi: 10.1016/S0143-4004(98)91045-1
[25]	Basak S,Vilasagaram S,Naidu K,et al. Insulin-dependent,glucose transporter 1 mediated glucose uptake and tube formation in the human placental first trimester trophoblast cells[J]. Mol Cell Biochem,2019,451(1-2):91-106. doi: 10.1007/s11010-018-3396-7
[26]	Jansson T,Ekstrand Y,Wennergren M,et al. Placental glucose transport in gestational diabetes mellitus[J]. Am J Obstet Gynecol,2001,184(2):111-116. doi: 10.1067/mob.2001.108075
[27]	Gaither K,Quraishi A N,Illsley N P. Diabetes alters the expression and activity of the human placental GLUT1 glucose transporter[J]. J Clin Endocrinol Metab,1999,84(2):695-701.
[28]	Yao G,Zhang Y,Wang D,et al. GDM-induced macrosomia is reversed by Cav-1 via AMPK-mediated fatty acid transport and GLUT1-mediated glucose transport in placenta[J]. PLoS One,2017,12(1):1-18.
[29]	Stanirowski P J,Lipa M,Bomba-Opoń D,et al. Expression of placental glucose transporter proteins in pregnancies complicated by fetal growth disorders[J]. Adv Protein Chem Struct Biol,2021(123):95-131.
[30]	Joshi N P,Mane A R,Sahay A S,et al. Role of placental glucose transporters in determining fetal growth[J]. Reprod Sci,2021,23(5):114-119.
[31]	Sciullo E,Cardellini G,Baroni M,et al. Glucose transporters (GLUT 1,GLUT 3) mRNA in human placenta of diabetic and non-diabetic pregnancies[J]. Ann Ist Super Sanita,1997,33(3):361-365.
[32]	Kainulainen H,Järvinen T,Heinonen P K. Placental glucose transporters in fetal intrauterine growth retardation and macrosomia[J]. Gynecol Obstet Invest,1997,44(2):89-92. doi: 10.1159/000291493
[33]	Valent A M,Choi H,Kolahi K S,et al. Hyperglycemia and gestational diabetes suppress placental glycolysis and mitochondrial function and alter lipid processing[J]. Faseb J,2021,35(3):e21423.
[34]	Carey E A,Albers R E,Doliboa S R,et al. AMPK knockdown in placental trophoblast cells results in altered morphology and function[J]. Stem Cells Dev,2014,23(23):2921-2930. doi: 10.1089/scd.2014.0092
[35]	Martino J,Sebert S,Segura M T,et al. Maternal body weight and gestational diabetes differentially influence placental and pregnancy outcomes[J]. J Clin Endocrinol Metab,2016,101(1):59-68. doi: 10.1210/jc.2015-2590
[36]	凌晓娟,黄震,李红霞. 孕妇体重和妊娠期糖尿病对胎盘和妊娠结局的影响[J]. 中国实验诊断学,2019,23(7):1109-1116. doi: 10.3969/j.issn.1007-4287.2019.07.001
[37]	Shang M,Wen Z. Increased placental IGF-1/mTOR activity in macrosomia born to women with gestational diabetes[J]. Diabetes Res Clin Pract,2018,146(8):211-219.
[38]	Jansson T,Aye I L,Goberdhan D C. The emerging role of mTORC1 signaling in placental nutrient-sensing[J]. Placenta,2012,33(11):e23-29.
[39]	Roos S,Lagerlöf O,Wennergren M,et al. Regulation of amino acid transporters by glucose and growth factors in cultured primary human trophoblast cells is mediated by mTOR signaling[J]. Am J Physiol Cell Physiol,2009,297(3):723-731. doi: 10.1152/ajpcell.00191.2009
[40]	Dennis P B,Jaeschke A,Saitoh M,et al. Mammalian TOR:A homeostatic ATP sensor[J]. Science,2001,294(5544):1102-1105. doi: 10.1126/science.1063518
[41]	Xu J,Lu C,Wang J,et al. Regulation of human trophoblast GLUT3 glucose transporter by mammalian target of rapamycin signaling[J]. Int J Mol Sci,2015,16(6):13815-13828.
[42]	Muralimanoharan S,Maloyan A,Myatt L. Mitochondrial function and glucose metabolism in the placenta with gestational diabetes mellitus:Role of miR-143[J]. Clin Sci (Lond),2016,130(11):931-941. doi: 10.1042/CS20160076
[43]	Baumann M U,Schneider H,Malek A,et al. Regulation of human trophoblast GLUT1 glucose transporter by insulin-like growth factor I (IGF-I)[J]. PLoS One,2014,9(8):1-28.

Relative Articles(20)

Relative Articles

[1]	Xiuhua WANG, Zeran HE, Zhihong LI, Huiling WANG, Hongyan SU. Clinical Application Evaluation and Standard，Reasonable Use of Fat Emulsion，Amino Acids （17） and Glucose （11%） Injection. Journal of Kunming Medical University, 2023, 44(3): 138-142. doi: 10.12259/j.issn.2095-610X.S20230318
[2]	Fang SUN, Shiying HUANG, Shu LIU, Jingyun FU. Association between Glucose Time in Range and Carotid Artery Intima-media Thickness in Type-2 Diabetes Mellitus. Journal of Kunming Medical University, 2023, 44(4): 48-52. doi: 10.12259/j.issn.2095-610X.S20230427
[3]	Fan ZHANG, Weichang GUO, Hong TAN, Hejia YIN, Luping PENG, Yan ZHAO, Huifang LI. Development and Validation of Risk Predicting Model for Severe Diabetic Peripheral Neuropathy Based on Glucose Variability Parameters. Journal of Kunming Medical University, 2023, 44(5): 53-59. doi: 10.12259/j.issn.2095-610X.S20230526
[4]	Yaling ZHAO, Kun WU, Kai WANG, Rong HUANG, Genya HE, Yuhui NA, Miao HE, Zhenbo DING, Caiying ZHANG. Influence of Intrauterine Hyperglycemia Environment on Peripheral Inflammatory Response in Offspring of Gestational Diabetes Mellitus. Journal of Kunming Medical University, 2023, 44(11): 70-75. doi: 10.12259/j.issn.2095-610X.S20231110
[5]	Qingyao YANG, Jie ZENG, Weiquan ZHANG, Yue NING, Meng LI, Zhanhua LI, Mei LIU, Jingjing XIONG, Yongkun HUANG. Differences of Placental Microbiota DNA between Gestational Diabetes Mellitus and Normal Full-term Mothers. Journal of Kunming Medical University, 2023, 44(10): 140-148. doi: 10.12259/j.issn.2095-610X.S20231006
[6]	Na-na RONG, YU-feng LI, Li-yue REN, Yue-xin HU. Determination of Norfloxacin Glucose Injection in EDTA by RP-HPLC Method. Journal of Kunming Medical University, 2021, 42(8): 35-39. doi: 10.12259/j.issn.2095-610X.S20210807
[7]	Dai Yi Cong , Chen Feng Rong , Wang Kun Hua . . Journal of Kunming Medical University, 2020, 41(09): 142-148.
[8]	Zhang Jin Shan , Shen Shao Cong , Li Lv , Wang Qi , You Shu Min , Zhang Cai Jun . . Journal of Kunming Medical University, 2019, 40(12): 28-33.
[9]	Yang Yi Mei , Kang Wei , Fan Wei , Dai Fu Rong , Sun Yu . . Journal of Kunming Medical University, 2019, 40(09): 96-100.
[10]	Su Hong , Sun Hong Li , Yang Jun . . Journal of Kunming Medical University, 2018, 39(09): 33-36.
[11]	Lin Yan , Zhang Jing Jing , Huang Gao Gui , Zhang Yi Yu , Rui Li , Yao Shu Xiang . Correlation of 5-HT Transporter Protein Gene (SLC6A4) Polymorphism and Conduct Disorder in Children. Journal of Kunming Medical University, 2017, 38(04): 28-31.
[12]	Liu Hui Jin , Yang Ying Ying , Pan Jing , Liu Yang , Li Xiao Yi , Zhou Hong Lin . Expression of Glucose-regulated Protein 94 in Cervical Lesion. Journal of Kunming Medical University, 2017, 38(07): 99-101.
[13]	Xiong Jing Jing , Qi Wen Jin , Hu Hong Wei , Zeng Jie , Huang Rong , Ma Run Mei , Liu Mei , Huang Yong Kun . The Detection and Analysis of the Placenta Microbiota of Normal Term Delivery. Journal of Kunming Medical University, 2017, 38(11): 52-57.
[14]	Zhang Mi Li . . Journal of Kunming Medical University,
[15]	Lei Chun Lian . . Journal of Kunming Medical University,
[16]	Jin Di . . Journal of Kunming Medical University,
[17]	Chai Yan Jing . . Journal of Kunming Medical University,
[18]	Shi Hai Ying . . Journal of Kunming Medical University,
[19]	. Insulin Resistance and β-cell Secretion in Women with Normal Glucose Tolerance and Gestational Diabetes Mellitus. Journal of Kunming Medical University,
[20]	Hong Yun . . Journal of Kunming Medical University,