Risk Factors for Hypoparathyroidism after Thyroidectomy

Wanyou JIA; Hongli LIU; Weiwei JIANG; Hongmin LI; Shuo ZHANG; Jimin FEI

doi:10.12259/j.issn.2095-610X.S20220904

Volume 43 Issue 9

Sep. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(9): 84-89

Wanyou JIA, Hongli LIU, Weiwei JIANG, Hongmin LI, Shuo ZHANG, Jimin FEI. Risk Factors for Hypoparathyroidism after Thyroidectomy[J]. Journal of Kunming Medical University, 2022, 43(9): 84-89. doi: 10.12259/j.issn.2095-610X.S20220904

Citation:

Wanyou JIA, Hongli LIU, Weiwei JIANG, Hongmin LI, Shuo ZHANG, Jimin FEI. Risk Factors for Hypoparathyroidism after Thyroidectomy[J]. Journal of Kunming Medical University, 2022, 43(9): 84-89. doi: 10.12259/j.issn.2095-610X.S20220904

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Risk Factors for Hypoparathyroidism after Thyroidectomy

doi: 10.12259/j.issn.2095-610X.S20220904

The 2nd Dept. of Head and Neck Surgery，Yunnan Cancer Hospital/The 3rd Affiliated Hospital of Kunming Medical University & Yunnan Cancer Center， Kunming Yunnan 650118，China

Received Date: 2022-06-05
Publish Date: 2022-09-25

Abstract

Abstract

Objective To explore the risk factors of hypoparathyroidism （HypoPT） after thyroidec-tomy and analyze the relationship between the number of coexisting risk factors and the incidence of HypoPT, so as to guide the clinical treatment. Methods A total of 266 patients with the complete data after the thyroidectomy in Yunnan Cancer Hospital from July 2021 to March 2022 were retrospectively analyzed. Univariate analysis and multivariate Logistic regression were used to analyze the risk factors of HypoPT and the relationship between the number of co-existing risk factors and the incidence of HypoPT. Results （1） Univariate analysis results: There were statistically significant differences in age, body mass index （BMI）, hypertension, metabolic syndrome （MS）, mass nature, T stage, central lymph node dissection （CLND） , lymph node metastasis, surrounding invasion, gland lobectomy method （unilateral total resection, bilateral total resection）（P < 0.05）; （2） Logistic multivariate analysis results: MS, CLND, tumor nature, Lymph node metastasis were the independent risk factors for the incidence of HypoPT （ P < 0.05）; （3） After adjusting for age and other clinical factors, there was a positive correlation between the number of risk factors and the incidence of HypoPT. Conclusion （1） Age, BMI, hypertension, MS, mass nature, T stage, CLND, lymph node metastasis, peripheral invasion, and gland lobectomy method will affect the incidence of HypoPT; （2） MS, CLND, mass nature, lymph node metastasis are independent risk factor for HypoPT; （3） There is a positive correlation between the number of risk factor and the incidence of HypoPT.
- Hypoparathyroidism,
- Metabolic syndrome,
- Risk factors

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References(20)

References

[1]	中华人民共和国国家卫生健康委员会 . 甲状腺癌诊疗规范（2018年版）[J]. 中华普通外科学文献（电子版）, 2019, 13（1）: 1-15.
[2]	朱精强,田文,苏安平. 甲状腺围手术期甲状旁腺功能保护指南(2018版)[J]. 中国实用外科杂志,2018,38(10):1108-1113. doi: 10.19538/j.cjps.issn1005-2208.2018.10.03
[3]	Imga N N,Atas H,Torgutalp M,et al. Stratifying the risk factors for hypoparathyroidism after total thyroidectomy. A single center’ study[J]. Ann Ital Chir,2019,90(1):21-30.
[4]	欧亮,赵志泓,孙振华,等. 甲状腺乳头状癌术后甲状旁腺功能减退发生情况及严重程度的相关风险分析[J]. 江苏医药,2021,47(8):772-776. doi: 10.19460/j.cnki.0253-3685.2021.08.005
[5]	Qiu Y,Xing Z,Fei Y,et al. Role of the 2018 American thyroid association statement on postoperative hypoparathyroidism:A 5-year retrospective study[J]. BMC Surg,2021,21(1):334. doi: 10.1186/s12893-021-01333-w
[6]	D í ez J J,Anda E,Sastre J,et al. Recovery of parathyroid function in patients with thyroid cancer treated by total thyroidectomy:An analysis of 685 patients with hypoparathyroidism at discharge of surgery[J]. Endocrinol Diabetes Nutr (Engl Ed),2021,68(6):398-407.
[7]	Mencio M,Calcatera N,Ogola G,et al. Factors contributing to unintentional parathyroidectomy during thyroid surgery[J]. Proc (Bayl Univ Med Cent),2019,33(1):19-23.
[8]	Salem FA,Bergenfelz A,Nordenström E,et al. Central lymph node dissection and permanent hypoparathyroidism after total thyroidectomy for papillary thyroid cancer:Population-based study[J]. Br J Surg,2021,108(6):684-690.
[9]	Chen Z, Zhao Q, Du J, et al. Risk factors for postoperative hypocalcaemia after thyroidectomy: A systematic review and meta-analysis[J]. J Int Med Res, 2021, 49（3):1-21.
[10]	Ru Z,Mingliang W,Maofei W,et al. Analysis of risk factors for hypoparathyroidism after total thyroidectomy[J]. Front Surg,2021,8(21):668-672.
[11]	Su A,Wang B,Gong Y,et al. Risk factors of hypoparathyroidism following total thyroidectomy with central lymph node dissection[J]. Medicine (Baltimore),2017,96(39):e8162.
[12]	冯洪雨. 代谢综合征与甲状腺癌的相关性研究[D]. 唐山: 华北理工大学硕士学位论文, 2020.
[13]	Orloff LA,Wiseman SM,Bernet VJ,et al. American thyroid association statement on postoperative hypoparathyroidism:Diagnosis,prevention,and management in adults[J]. Thyroid,2018,28(7):830-841. doi: 10.1089/thy.2017.0309
[14]	徐国栋,凌煜玮,朱江,等. 甲状腺癌术后迁延性甲状旁腺功能减退风险的列线图预测模型研究[J]. 中国普外基础与临床杂志,2022,29(1):24-31.
[15]	Fanget F,Demarchi MS,Maillard L,et al. Hypoparathyroidism:Consequences,economic impact,and perspectives. A case series and systematic review[J]. Ann Endocrinol (Paris),2021,82(6):572-581. doi: 10.1016/j.ando.2021.07.085
[16]	田文,张浩. 甲状腺外科能量器械应用专家共识(2017版)[J]. 中国实用外科杂志,2017,37(9):992-997. doi: 10.19538/j.cjps.issn1005-2208.2017.09.14
[17]	Sitges-Serra A. Etiology and diagnosis of permanent hypoparathyroidism after total thyroidectomy[J]. J Clin Med,2021,10(3):543. doi: 10.3390/jcm10030543
[18]	Tian W,Jiang Y,Gao B,et al. Application of nano-carbon in lymph node dissection for thyroid cancer and protection of parathyroid glands[J]. Med Sci Monit,2014,20(10):1925-1930.
[19]	Qiu Y,Xing Z,Xiang Q,et al. Duration of parathyroid function recovery in patients with protracted hypoparathyroidism after total thyroidectomy for papillary thyroid carcinoma[J]. Frontiers in Endocrinology,2021,12(4):665-673.
[20]	Lorente-Poch L,Sancho J J,Ruiz S,et al. Importance of in situ preservation of parathyroid glands during total thyroidectomy[J]. Br J Surg,2015,102(4):359-367. doi: 10.1002/bjs.9676

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