Effect of VitD Supplementation on the Improvement of Autoimmune Thyroiditis in Childbearing Age Females

Chen WANG; Sha LI; Boxue ZHANG; Jinhua HE

doi:10.12259/j.issn.2095-610X.S20220907

Volume 43 Issue 9

Sep. 2022

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Chen WANG, Sha LI, Boxue ZHANG, Jinhua HE. Effect of VitD Supplementation on the Improvement of Autoimmune Thyroiditis in Childbearing Age Females[J]. Journal of Kunming Medical University, 2022, 43(9): 135-140. doi: 10.12259/j.issn.2095-610X.S20220907

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Chen WANG, Sha LI, Boxue ZHANG, Jinhua HE. Effect of VitD Supplementation on the Improvement of Autoimmune Thyroiditis in Childbearing Age Females[J]. Journal of Kunming Medical University, 2022, 43(9): 135-140. doi: 10.12259/j.issn.2095-610X.S20220907

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Effect of VitD Supplementation on the Improvement of Autoimmune Thyroiditis in Childbearing Age Females

doi: 10.12259/j.issn.2095-610X.S20220907

1.
Dept. of Endocrinology, Tangshan Workers' Hospital , Tangshan Heibei 063000
2.
Dept. of Endocrinology, The 2nd Hospital of Shijiazhuang City, Shijiazhuang Heibei 050000, China

Received Date: 2022-06-26
Available Online: 2022-09-08
Publish Date: 2022-09-29

Abstract

Abstract

Objective To investigate the effects of vitamin D supplementation on thyroid function, autoimmune antibody and serum 25 （OH） D levels in female patients with autoimmune thyroiditis （AT） in the reproductive age. Methods 94 childbearing age females with AT and admitted to the department of endocrinology of our hospital from January 2019 to August 2021 were enrolled as subjects. According to random number table method, they were randomly assigned to two groups, the control group （n = 47） and the study group （n = 47）, and the parallel control were conducted. All the subjects received the instruction of life style and diet style, the study group received the oral Thyroid hormone and Vitamin D therapy, while the control group only received the oral Thyroid hormone therapy. Thereafter, serum Thyroid hormone levels （FT3, TSH and FT4）, thyroid autoantibodies （TRAb, TPO-Ab） and 25 （OH） D were measured and compared between the two groups at different stages. Results （1）Thyroid function: Compared with the situation before the treatment, serum FT3, TSH and FT4 were improved to varying degrees in 2 groups after 6 months of treatment （P < 0.01）, the serum TSH content in the study group was apparently higher than that in the control group [（2.34±0.33） μIU/mL VS （2.19±0.36） μIU/mL], and the results were statistically significant （P < 0.05）. （2） Thyroid autoimmune antibody: After 6 months of treatment, serum TRAb and TPO-Ab levels in the study group were evidently better, compared to the control group [（0.56±0.38） U/L VS （4.35±1.71） U/L; （35.71±8.85） U/mL VS （77.41±19.91） U/mL] （P < 0.01）, lower than TRAb and TPO-Ab levels before treatment and 3 months after the treatment （P < 0.01）. （3） Serum 25 （OH）D level: Compared with the situation before the treatment, the serum 25 （OH）D level of the study group increased significantly after 6 months of treatment （P < 0.05）, evidently better than that in the control group [（61.91±8.73） ng/mL VS （10.79±3.16） ng/mL] （P < 0.05）. Conclusion Vitamin D supplementation can significantly improve serum 25 （OH） D level and autoimmune antibody titer in patients with autoimmune thyroiditis in the short term （6 months）, but the effect on Thyroid hormone levels is not obvious and it can be used as an adjunctive treatment for autoimmune thyroiditis patientswith low vitamin D level.
- Vitamin D,
- Painless thyroiditis,
- Women,
- Autoimmune antibody

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References(27)

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