Advances on the Relationship between Protein S-nitrosylation and Digestive System Tumors

Yu LV; Yibo HU; Jiaxin WANG; Youtong SU; Youguo DAI

doi:10.12259/j.issn.2095-610X.S20220911

Volume 43 Issue 9

Sep. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(9): 155-159

Yu LV, Yibo HU, Jiaxin WANG, Youtong SU, Youguo DAI. Advances on the Relationship between Protein S-nitrosylation and Digestive System Tumors[J]. Journal of Kunming Medical University, 2022, 43(9): 155-159. doi: 10.12259/j.issn.2095-610X.S20220911

Citation:

Yu LV, Yibo HU, Jiaxin WANG, Youtong SU, Youguo DAI. Advances on the Relationship between Protein S-nitrosylation and Digestive System Tumors[J]. Journal of Kunming Medical University, 2022, 43(9): 155-159. doi: 10.12259/j.issn.2095-610X.S20220911

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Advances on the Relationship between Protein S-nitrosylation and Digestive System Tumors

doi: 10.12259/j.issn.2095-610X.S20220911

1.
Dept. of Emergency Medicine，Zhejiang Provincial People’s Hospital/Affiliated People’s Hospital，Hangzhou Medical College of Hangzhou Zhejiang 310014
2.
Dept. of Gastrointestinal Surgery
3.
Dept. of Palliative Medicine，The 3rd Affiliated Hospital of Kunming Medical University/Yunnan Cancer Hospital/Yunnan Cancer Center，Kunming Yunnan 650118，China

Received Date: 2022-06-11
Publish Date: 2022-09-25

Abstract

Abstract

S-nitrosylation modification is a selective and reversible post-translational modification of protein by high concentration of nitric oxide （NO）, which is related to a variety of cellular processes and tissue homeostasis. Most digestive system tumors interact with the development of inflammation. The body induces a great deal of NO in an inflammatory state and NO can modify the substrate protein S-nitrosylation. At present, it has been found that the expression of S-nitrosylation of proteins in a variety of cancer tissues is abnormal. Relevant studies at home and abroad show that the relationship between S-nitrosylation and tumor occurrence and development has become a current research focus. By briefly describing the mechanism of protein S-nitrosylation imbalance in the occurrence and development of different digestive system tumors and treatments,this review concludes that S-nitrosylation imbalance in different digestive system tumors can promote or inhibit the development of tumors through the S-nitrosylation of different proteins and aims to tap the therapeutic potential of S-nitrosylation level in digestive system tumors.
- Protein,
- S-nitrosylation,
- Nitric oxide,
- Digestive system tumor

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References(37)

References

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