Comparative Analysis of Behavioral and Psychological Symptoms of Dementia in Patients with Alzheimer's Disease and Mild Cognitive Impairment

Huiping HE; Yaowei HE; Zonglin SHEN; Xiaoxiao SONG; Baoluo LI; Hongyan JIANG

doi:10.12259/j.issn.2095-610X.S20220913

Volume 43 Issue 9

Sep. 2022

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Huiping HE, Yaowei HE, Zonglin SHEN, Xiaoxiao SONG, Baoluo LI, Hongyan JIANG. Comparative Analysis of Behavioral and Psychological Symptoms of Dementia in Patients with Alzheimer's Disease and Mild Cognitive Impairment[J]. Journal of Kunming Medical University, 2022, 43(9): 19-23. doi: 10.12259/j.issn.2095-610X.S20220913

Citation:

Huiping HE, Yaowei HE, Zonglin SHEN, Xiaoxiao SONG, Baoluo LI, Hongyan JIANG. Comparative Analysis of Behavioral and Psychological Symptoms of Dementia in Patients with Alzheimer's Disease and Mild Cognitive Impairment[J]. Journal of Kunming Medical University, 2022, 43(9): 19-23. doi: 10.12259/j.issn.2095-610X.S20220913

Citation:

Huiping HE, Yaowei HE, Zonglin SHEN, Xiaoxiao SONG, Baoluo LI, Hongyan JIANG. Comparative Analysis of Behavioral and Psychological Symptoms of Dementia in Patients with Alzheimer's Disease and Mild Cognitive Impairment[J]. Journal of Kunming Medical University, 2022, 43(9): 19-23. doi: 10.12259/j.issn.2095-610X.S20220913

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Comparative Analysis of Behavioral and Psychological Symptoms of Dementia in Patients with Alzheimer's Disease and Mild Cognitive Impairment

doi: 10.12259/j.issn.2095-610X.S20220913

1.
Dept.of Psychiatry，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650031
2.
School of Public Health，Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2022-06-19
Available Online: 2022-09-07
Publish Date: 2022-09-29

Abstract

Abstract

Objective To provide the guidance for the management of patients with Alzheimer’s disease （AD） and mild cognitive impairment （MCI） by analyzing the similarities and differences between them. Methods The Neuropsychiatric Inventory （NPI） was used to assess the prevalence and severity of behavioral and psychological symptoms of dementia in 71 patients with AD and 31 patients with MCI from Yunnan Province compared with 70 normal controls. Results The incidence and severity of depression, anxiety, and irritability were not significantly different between the AD and MCI groups （P > 0.05）, whereas they were higher in the MCI group than in the normal control group （P < 0.05）. There was no significant difference in the incidence of apathy between AD and MCI groups （P > 0.05）, and the severity of apathy was higher in the AD group than that in the MCI group （P < 0.05）. However, the incidence and severity of apathy in the MCI group were higher than those in normal controls （P < 0.05）. The NPI total score and the incidence or severity of the remaining symptoms were higher in the AD group than in the MCI group （P < 0.05）, whereas there were no significant differences in the incidence or severity between the MCI group and normal controls （P > 0.05）. Conclusion The overall BPSD of AD patients is more severe than that of MCI patients, while the symptoms of depression, anxiety, and irritability are not different between AD and MCI patients. MCI is at the transition stage of cognitive changes between normal aging and AD, and MCI patients with these symptoms need to be paid attention to and intervened early.
- Alzheimer's disease,
- Mild cognitive impairment,
- Behavioral and psychological symptoms of dementia.

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References(16)

References

[1]	Petersen R C. Mild cognitive impairment[J]. Continuum (Minneap Minn),2016,22(2 Dementia):404-418.
[2]	Siafarikas N,Selbaek G,Fladby T,et al. Frequency and subgroups of neuropsychiatric symptoms in mild cognitive impairment and different stages of dementia in Alzheimer's disease[J]. International Psychogeriatrics,2018,30(1):103-111.
[3]	Mallo S C,Valladares-Rodriguez S,Facal D,et al. Neuropsychiatric symptoms as predictors of conversion from MCI to dementia:A machine learning approach[J]. Int Psychogeriatr,2020,32(3):381-392. doi: 10.1017/S1041610219001030
[4]	王峡,吕洋,付雪,等. 基于记忆障碍门诊评价轻度认知功能障碍及阿尔茨海默病患者的精神行为症状[J]. 重庆医科大学学报,2019,44(4):441-447. doi: 10.13406/j.cnki.cyxb.001927
[5]	Jack Clifford R,Albert Marilyn S,Knopman David S,et al. Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association Workgroups on diagnostic guidelines for Alzheimer's disease[J]. Alzheimers & Dementia,2011,7(3):257-262.
[6]	Portet F,Ousset P J,Visser P J,et al. Mild cognitive impairment (MCI) in medical practice:A critical review of the concept and new diagnostic procedure. Report of the MCI Working Group of the European Consortium on Alzheimer’s Disease[J]. Neurol Neurosurg Psychiatry,2006,77(6):714-718. doi: 10.1136/jnnp.2005.085332
[7]	Chen Suhong,Lin Kai,Wang Hanxiao,et al. Reliability and structural validity of the Chinese version of the neuropsychiatric inventory,nursing home version[J]. Psychogeriatrics,2018,18(2):113-122. doi: 10.1111/psyg.12292
[8]	Zhou G,Liu S,Yu X,et al. High prevalence of sleep disorders and behavioral and psychological symptoms of dementia in late-onset Alzheimer disease:A study in Eastern China[J]. Medicine (Baltimore),2019,98(50):e18405.
[9]	MartinE,VelayudhanL. Neuropsychiatric symptoms in mild cognitive impairment:A literature review[J]. Dement Geriatr Cogn Disord,2020,49(2):146-155. doi: 10.1159/000507078
[10]	李树亚,李峥. 轻度认知障碍老年人精神行为症状及影响因素的调查研究[J]. 中华护理杂志,2018,53(10):1192-1198. doi: 10.3761/j.issn.0254-1769.2018.10.007
[11]	Lee C H,Kim D H,Moon Y S. Differential associations between depression and cognitive function in MCI and AD:A cross-sectional study[J]. Int Psychogeriatr,2019,31(8):1151-1158. doi: 10.1017/S1041610218001527
[12]	Pietrzak R H,Lim Y Y,Neumeister A,et al. Amyloid-beta,anxiety,and cognitive decline in preclinical Alzheimer’s disease:A multicenter,prospective cohort study[J]. JAMA Psychiatry,2015,72(3):284-281.
[13]	李树亚. 轻度认知障碍患者淡漠、抑郁表现与认知功能各维度关系的研究[D]. 北京: 北京协和医学院硕士学位论文, 2018.
[14]	Ruthirakuhan M,Herrmann N,Vieira D,et al. The roles of apathy and depression in predicting Alzheimer disease:A longitudinal analysis in older adults with mild cognitive impairment[J]. Am J Geriatr Psychiatry,2019,27(8):873-882. doi: 10.1016/j.jagp.2019.02.003
[15]	Roberto N,Portella M J,Marquié M,et al. Neuropsychiatric profiles and conversion to dementia in mild cognitive impairment,a latent class analysis[J]. Sci Rep,2021,11(1):6448. doi: 10.1038/s41598-021-83126-y
[16]	Desai R,Whitfield T,Said G,et al. Affective symptoms and risk of progression to mild cognitive impairment or dementia in subjective cognitive decline:A systematic review and meta-analysis[J]. Ageing Res Rev,2021,71(2021):101419.

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