Clinical Effect of Reoperation for Recurrent Glioma

Xiaofeng ZHU; Guangping ZHOU; Laicang WANG; Houjun ZHOU; Xin GENG; Hualin YU; Jinghui LI; Peng BAI

doi:10.12259/j.issn.2095-610X.S20220920

Volume 43 Issue 9

Sep. 2022

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Article Navigation > Journal of Kunming Medical University > 2022 > 43(9): 77-83

Xiaofeng ZHU, Guangping ZHOU, Laicang WANG, Houjun ZHOU, Xin GENG, Hualin YU, Jinghui LI, Peng BAI. Clinical Effect of Reoperation for Recurrent Glioma[J]. Journal of Kunming Medical University, 2022, 43(9): 77-83. doi: 10.12259/j.issn.2095-610X.S20220920

Citation:

Xiaofeng ZHU, Guangping ZHOU, Laicang WANG, Houjun ZHOU, Xin GENG, Hualin YU, Jinghui LI, Peng BAI. Clinical Effect of Reoperation for Recurrent Glioma[J]. Journal of Kunming Medical University, 2022, 43(9): 77-83. doi: 10.12259/j.issn.2095-610X.S20220920

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Clinical Effect of Reoperation for Recurrent Glioma

doi: 10.12259/j.issn.2095-610X.S20220920

1.
The 2nd Department of Neurosurgery，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
2.
Dept. of Neurosurgery， The 5th People’s Hospital of Chengdu，Chengdu Sichuan 610000，China

Received Date: 2022-06-19
Available Online: 2022-09-08
Publish Date: 2022-09-29

Abstract

Abstract

Objective To analyze the clinical effect of multimodality microsurgery on recurrent gliomas, and to explore the diagnosis and treatment of recurrent gliomas. Methods Data of 28 patients with recurrent GLIOMAS who underwent reoperation from September 2017 to December 2020 in the Department of Neurosurgery of a tertiary grade A hospital in Kunming were collected and analyzed retrospectively, After the reoperation, the Karnofsky neurological function score （KPS） was used to evaluate the clinical efficacy, and the imaging data was used to evaluate the degree of tumor resection, the postoperative comparison of pathological changes of recurrent glioma, postoperative adjuvant treatment, follow-up patient survival time and other overall effects. Graphpad Prism （V8.4.2.679） software was used to analyze the data and graph. The difference in KPS scores before and after the operation was tested in pairs. Results 28 patients were treated with reoperations to varying degrees. Postoperative imaging confirmed that 21 cases of tumors were totally resected, 5 cases were subtotal resected, and 2 cases had tumor biopsy. Postoperative complications occurred in 22 patients. The clinical symptoms before discharge were improved in 24 cases compared with that before the operation, with an improvement rate of 85.7%. The mean KPS score was 66.07 ± 7.37 before the operation and 72.14 ± 11.00 one month after the operation.The differences were statistically significant. Postoperative pathology showed the progression of Malignancy in 8 cases. The mean survival time of 28 patients were （7.98 ± 6.42） months and the longest survival time were 24 months. Conclusion The combined application of multi-modality and multi-technique microsurgery is a relatively minimally invasive and effective treatment for recurrent glioma. The surgical effect is good, and it can be used as an option for surgical resection of recurrent glioma.
- Glioma,
- Recurrence,
- Reoperation,
- Therapeutic effect

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