Studies on the Correlation of Early Blood Uric Acid Fluctuation after Bariatric Surgery

Yuanqing CAO; Xiangyu ZI; Yankun ZHU; Baohong YUAN

doi:10.12259/j.issn.2095-610X.S20220924

Volume 43 Issue 9

Sep. 2022

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Yuanqing CAO, Xiangyu ZI, Yankun ZHU, Baohong YUAN. Studies on the Correlation of Early Blood Uric Acid Fluctuation after Bariatric Surgery[J]. Journal of Kunming Medical University, 2022, 43(9): 53-58. doi: 10.12259/j.issn.2095-610X.S20220924

Citation:

Yuanqing CAO, Xiangyu ZI, Yankun ZHU, Baohong YUAN. Studies on the Correlation of Early Blood Uric Acid Fluctuation after Bariatric Surgery[J]. Journal of Kunming Medical University, 2022, 43(9): 53-58. doi: 10.12259/j.issn.2095-610X.S20220924

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Studies on the Correlation of Early Blood Uric Acid Fluctuation after Bariatric Surgery

doi: 10.12259/j.issn.2095-610X.S20220924

The 1st Dept. of General Surgery， Yan'an Hospital, Kunming Yunnan 650051，China

Received Date: 2022-07-16
Available Online: 2022-09-07
Publish Date: 2022-09-29

Abstract

Abstract

Objective To explore the correlation of early serum uric acid fluctuations in patients after the bariatric surgery. Methods From January 2021 to June 2022, 80 patients with the metabolic syndrome who were admitted to Yan'an Hospital of Kunming and completed the follow-up one month after the surgery were selected as the objective of this research experiment.And according to the serum uric acid index one month after the surgery, they were divided into group A with the increase of serum uric acid after the operation and group B with the decrease of serum uric acid after the operation. The BMI value and the changes of various biochemical indexes were compared between the two groups before and after the bariatric surgery. Results Surgery method, postoperative protein intake, aerobic exercise and water intake were not the reasons for the fluctuation of serum uric acid in patients after weight loss（P > 0.05）, and the changes in liver function also could not explain the changes in patients 1 month after weight loss（P > 0.05）. The changes of blood sugar and triglyceride were the main reasons for the fluctuation of postoperative blood uric acid（P < 0.05）. The greater the decrease in triglycerides after the surgery, the less likely the increase in uric acid will occur.In addition, the increase of blood uric acid at 1 month after operation was greater than the decrease of blood uric acid after the operation, and the change of blood uric acid was correlated with the change of serum creatinine and monocyte/high-density lipoprotein（MHR）（P < 0.05）. The correlation coefficients were 0.204 and 0.511 respectively.respectively. Conclusion The changes of triglyceride and blood sugar in the early postoperative period are the reasons for the increase or decrease of blood uric acid in patients with weight loss after the surgery, and the changes of blood uric acid are mainly affected by creatinine and monocyte/high density.
- Metabolic syndrome,
- Hyperuricemia,
- Mononuclear cells/high-density lipoprotein,
- Laparoscopic sleeve gastrectomy,
- Laparoscopic gastric bypass

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References(17)

References

[1]	中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2017年版)[J]. 中华糖尿病杂志,2018,10(1):4-67. doi: 10.3760/cma.j.issn.1674-5809.2018.01.003
[2]	Noubiap J J,Nansseu J R,Lontchi-Yimagou E,et al. Global,regional,and country estimates of metabolic syndrome burden in children and adolescents in 2020:A systematic review and modelling analysis[J]. The Lancet Child & Adolescent Health,2022,6(4):158-170.
[3]	齐莹. 北京某社区成年体检人群代谢综合症流行现状分析[J]. 中国卫生统计,2020,37(4):590-592.
[4]	Pammer L M,Lamina C,Schultheiss U T,et al. Association of the metabolic syndrome with mortality and major adverse cardiac events:A large chronic kidney disease cohort[J]. Journal of Internal Medicine,2021,290(6):1219-1232. doi: 10.1111/joim.13355
[5]	梁辉,林士波,管蔚. 减重代谢外科手术方式的选择[J]. 中华胃肠外科杂志,2017,2(4):388-392. doi: 10.3760/cma.j.issn.1671-0274.2017.04.006
[6]	Gao B,Zhou J,Ge J,et al. Association of maximum weight with hyperuricemia risk:A retrospective study of 21,414 Chinese people[J]. Plos One,2012,7(11):e51186. doi: 10.1371/journal.pone.0051186
[7]	刘金钢,胡敬尧. 减重代谢外科新手术方式对学科发展的影响[J]. 中华消化外科杂志,2020,19(11):1135-1139. doi: 10.3760/cma.j.cn115610-20200820-00567
[8]	罗衡桂,唐彬,毛岳峰,等. 不同类型减重代谢手术治疗重度肥胖合并2型糖尿病的近期疗效分析[J]. 中国普通外科杂志,2020,29(10):1224-1233. doi: 10.7659/j.issn.1005-6947.2020.10.009
[9]	卢存龙. 减重手术对高尿酸血症大鼠代谢和肠道菌群的影响[D]. 青岛: 青岛大学硕士学位论文, 2018.
[10]	郭朋森. 减重手术后患者血清维生素B_（12）水平升高的危险因素探究[D]. 成都: 西南交通大学硕士学位论文, 2021.
[11]	Arterburn D E,Telem D A,Kushner R F,et al. Benefits and risks of bariatric surgery in adults:A review[J]. Jama,2020,324(9):879-887. doi: 10.1001/jama.2020.12567
[12]	Kwon Y,Kim H J,Menzo E L,et al. Anemia,iron and vitamin B12 deficiencies after sleeve gastrectomy compared to Roux-en-Y gastric bypass:A meta-analysis[J]. Surgery for Obesity and Related Diseases,2014,10(4):589-597. doi: 10.1016/j.soard.2013.12.005
[13]	Jean-Charles Fruchart,Patrick Duriez. HDL and triglyceride as the therapeutic targets[J]. Curr OPin LiPidol,2002,13(6):605-616. doi: 10.1097/00041433-200212000-00003
[14]	Amato M C,Giordano C,Galia M,et al. Visceral adiposity index:A reliable indicator of visceral fat function associated with cardiometabolic risk[J]. Diabetes Care,2010,33(4):920-922. doi: 10.2337/dc09-1825
[15]	杨阳,秦迁,闫肃,等. 正常体质量人群的内脏脂肪面积与尿酸的相关性研究[J]. 中国预防医学杂志,2022,23(2):115-120.
[16]	王燕萍,邬美花,杨胜,等. 单核细胞/高密度脂蛋白胆固醇与高尿酸血症患病率的关联及性别差异研究[J]. 中国全科医学,2022,25(6):714-718,723.
[17]	吴美豪,曹慧霞,王丽姣,等. 单核细胞/高密度脂蛋白比值与慢性肾脏病疾病严重程度及预后的关系[J]. 中华肾脏病杂志,2021,37(7):567-575. doi: 10.3760/cma.j.cn441217-20210202-00086

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