Study on the Correlation between Late-onset Breast Milk Jaundice and Defecation Frequency in Infants

Jingjing XIONG; Yuanyuan ZHANG; Meng LI; Yan CHEN; Mei LIU; Yongkun HUANG

doi:10.12259/j.issn.2095-610X.S20220925

Volume 43 Issue 9

Sep. 2022

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Jingjing XIONG, Yuanyuan ZHANG, Meng LI, Yan CHEN, Mei LIU, Yongkun HUANG. Study on the Correlation between Late-onset Breast Milk Jaundice and Defecation Frequency in Infants[J]. Journal of Kunming Medical University, 2022, 43(9): 34-37. doi: 10.12259/j.issn.2095-610X.S20220925

Citation:

Jingjing XIONG, Yuanyuan ZHANG, Meng LI, Yan CHEN, Mei LIU, Yongkun HUANG. Study on the Correlation between Late-onset Breast Milk Jaundice and Defecation Frequency in Infants[J]. Journal of Kunming Medical University, 2022, 43(9): 34-37. doi: 10.12259/j.issn.2095-610X.S20220925

Citation:

Jingjing XIONG, Yuanyuan ZHANG, Meng LI, Yan CHEN, Mei LIU, Yongkun HUANG. Study on the Correlation between Late-onset Breast Milk Jaundice and Defecation Frequency in Infants[J]. Journal of Kunming Medical University, 2022, 43(9): 34-37. doi: 10.12259/j.issn.2095-610X.S20220925

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Study on the Correlation between Late-onset Breast Milk Jaundice and Defecation Frequency in Infants

doi: 10.12259/j.issn.2095-610X.S20220925

Jingjing XIONG^{1, 2},
Yuanyuan ZHANG¹,
Meng LI^{1, 2},
Yan CHEN¹,
Mei LIU¹,
Yongkun HUANG^{1, 2
,
,}

1.
Dept. of Pediatrics，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan，650032
2.
Yunnan Key Laboratory of Laboratory Medicine， Kunming Yunnan 650032，China

Received Date: 2022-06-17
Available Online: 2022-09-07
Publish Date: 2022-09-29

Abstract

Abstract

Objective To analyze the correlation factors of late-onset breast-feeding jaundice （LBMJ）, and provide the reference for the study of LBMJ etiology. Methods 102 full-term breast-fed infants aged 0-6 months from the First Affiliated Hospital of Kunming Medical University were selected as the participants of this study and according to their defecation frequency they were divided respectively into defecation frequency increased group or group A, i.e. defecation > 3 times / D （ n = 37）, decreased defecation frequency group or group B, i.e. one defecation in more than 4 days （n = 34） and the normal group or group C, i.e. defecating once within 3 days or 3 times a day （n = 31）. All the infants with jaundice were LBMJ and the correlation between LBMJ and defecation frequency, age and feeding frequency was analyzed. Results 1. There was a statistical difference between the age of exclusively breast-fed infants and their different defecation frequency （Hc =7.8007, P = 0.0202）. There was no significant difference between the change of defecation frequency and the absence of LBMJ （χ² = 5.8649, P = 0.0533）, but the incidence of LBMJ increased with the increase of defecation frequency （χ² =5.7593, P = 0.0164）. 2. LBMJ was positively correlated with the defecation frequency and feeding frequency in infants, and the above factors were negatively correlated with the age of infants. Conclusion The younger the infants aged from 0 to 6 months, the more frequent the breastfeeding, the more frequent the defecation and the higher the incidence of LBMJ. In addition, the enhancement of bilirubin enterohepatic circulation pathway in LBMJ has little correlation with the increased defecation frequency in infants.
- Late-onset breast milk jaundice,
- Infant,
- Defecation frequency,
- Breast feeding,
- Factor analysis.

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References(17)

References

[1]	绍肖梅,叶鸿瑁,丘小汕. 实用新生儿学[J]. 北京:人民出版社,2019:455-456.
[2]	Weng Y H,Cheng S W,Yang C Y,et al. Risk assessment of prolonged jaundice in infants at one month of age:A prospective cohort study[J]. Scientific Reports,2018,8(1):14824. doi: 10.1038/s41598-018-33249-6
[3]	孙雨,周炳文,缪东幸. 母乳性黄疸发病机制的研究进展[J]. 医学综述,2013,19(11):1963-1966. doi: 10.3969/j.issn.1006-2084.2013.11.014
[4]	朱琳涵. 母乳性黄疸的诊断和治疗[J]. 中国医刊,2016,51(6):1-4. doi: 10.3969/j.issn.1008-1070.2016.06.001
[5]	杨英莲,陈贻骥. 母乳性黄疸发病机制研究进展[J]. 重庆医学,2013,42(14):1659-1661. doi: 10.3969/j.issn.1671-8348.2013.14.037
[6]	贾尔肯阿依·阿不都拉依,寇新红,陈凤娟,等. 迟发型母乳性黄疸患儿肠道菌群特征研究[J]. 中国妇幼卫生杂志,2022,13(1):57-61. doi: 10.19757/j.cnki.issn1674-7763.2022.01.012
[7]	Xiao L L,Zhang X F,Wang X Y. Changes in epidermal growth factor concentrations in neonates with late-onset breast milk jaundice after stopping breast feeding[J]. Zhong Guo Dang Dai Er Ke Za Zhi,2013,15(12):1079-1081.
[8]	杨晓云,张林,朱自伟. 新生儿黄疸消退延迟的相关因素分析[J]. 中国医药指南,2017,15(19):30-31. doi: 10.15912/j.cnki.gocm.2017.19.019
[9]	Weng Y H,Chiu Y W,Cheng S W. Breast milk jaundice and maternal diet with chinese herbal medicines[J]. Evid Based Complement Alternat Med,2012,2012:150120. doi: 10.1155/2012/150120
[10]	Elmassry M M,Kim S,Busby B. Predicting drug-metagenome interactions:Variation in the microbial β-glucuronidase level in the human gut metagenomes[J]. PLoS One,2021,16(1):e0244876. doi: 10.1371/journal.pone.0244876
[11]	Yang Y Y,Tsai T H. Enterohepatic circulation and pharmacokinetics of genistin and genistein in rats[J]. ACS Omega,2019,4(19):18428-18433. doi: 10.1021/acsomega.9b02762
[12]	Little M S,Pellock S J,Walton W G,et al. Structural basis for the regulation of β-glucuronidase expression by human gut enterobacteriaceae[J]. Proc Natl Acad Sci U S A,2018,115(2):E152-e161.
[13]	Zhou S,Wang Z,He F,et al. Association of serum bilirubin in newborns affected by jaundice with gut microbiota dysbiosis[J]. The Journal of Nutritional Biochemistry,2018,63(9):54-61. doi: 10.1016/j.jnutbio.2018.09.016.Epub2018Sep26
[14]	茹彩旺,秦涛,王玲,等. 母乳和新生儿粪便细菌与母乳性黄疸的相关性分析[J]. 中国微生态学杂志,2015,27(3):325-327. doi: 10.13381/j.cnki.cjm.201503020
[15]	李亚璇. 母乳外泌体miRNA调节肠道菌群与母乳性黄疸的相关机制研究[D]. 上海: 上海交通大学硕士论文, 2019.
[16]	Apaydin K,Ermis B,Arasli M,et al. Cytokines in human milk and late-onset breast milk jaundice[J]. Pediatr Int,2012,54(6):801-805. doi: 10.1111/j.1442-200X.2012.03680.x
[17]	Nagao Y,Ohsawa M,Kobayashi T. Correlation between unconjugated bilirubin and total cholesterol in the sera of 1-month-old infants[J]. J Paediatr Child Health,2010,46(12):709-713. doi: 10.1111/j.1440-1754.2010.01826.x

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