Perinatal Risk Factors of Neonatal Hyperthyrotropinemia

Caiying ZHANG; Zhengping KUI; Qiong WANG; Xiaolong ZHAO; Xiaomei HOU; Zhiye QI

doi:10.12259/j.issn.2095-610X.S20220929

Volume 43 Issue 9

Sep. 2022

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2022 > 43(9): 48-52

Caiying ZHANG, Zhengping KUI, Qiong WANG, Xiaolong ZHAO, Xiaomei HOU, Zhiye QI. Perinatal Risk Factors of Neonatal Hyperthyrotropinemia[J]. Journal of Kunming Medical University, 2022, 43(9): 48-52. doi: 10.12259/j.issn.2095-610X.S20220929

Citation:

Caiying ZHANG, Zhengping KUI, Qiong WANG, Xiaolong ZHAO, Xiaomei HOU, Zhiye QI. Perinatal Risk Factors of Neonatal Hyperthyrotropinemia[J]. Journal of Kunming Medical University, 2022, 43(9): 48-52. doi: 10.12259/j.issn.2095-610X.S20220929

Citation:

PDF( 616 KB)

Perinatal Risk Factors of Neonatal Hyperthyrotropinemia

doi: 10.12259/j.issn.2095-610X.S20220929

1.
Dept. of Pediatrics
2.
Neonatal Screening Center
3.
Dept. of Obstetrics，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2022-06-02
Available Online: 2022-09-16
Publish Date: 2022-09-29

Abstract

Abstract

Objective To investigate the association between neonatal Hyperthyrotropinemia （HT） and perinatal risk factors. Methods A case-control study was conducted among 109 newborns with HT （case group） and 127 newborns without HT （control group） in the First Affiliated Hospital of Kunming Medical University from Jan. 2016 to Dec. 2020. Univariate and multivariate logistic regression analysis was conducted to identify the perinatal risk factors to neonatal HT. Results Univariate analysis indicated that the incidence of advanced maternal age and preterm delivery in the case group were significantly higher than those in the control group. The results of multivariate logistic regression analysis showed that advanced maternal age （OR = 2.320, 95%CI: 1.099～4.897）and preterm delivery （OR = 2.960, 95%CI: 1.354～6.473） increased the risk of neonatal HT. Conclusion Advanced maternal age and preterm delivery were the independent perinatal risk factors for neonatal HT. Efforts should be made to provide high quality pregnancy care, decrease the perinatal risk factors of neonatal HT, and to reduce the incidence of neonatal HT.
- Perinatal period,
- Newborn,
- Hyperthyrotropinemia,
- Risk factor,
- Case-control study

FullText(HTML)

References(27)

References

[1]	Deng K,He C,Zhu J,et al. Incidence of congenital hypothyroidism in China:Data from the national newborn screening program,2013-2015[J]. J Pediatr Endocrinol Metab,2018,31(6):601-608. doi: 10.1515/jpem-2017-0361
[2]	Connelly K J,Lafranchi S H. Detection of neonates with mild congenital hypothyroidism (primary) or isolated hyperthyrotropinemia:An increasingly common management dilemma[J]. Expert Rev Endocrinol Metab,2014,9(3):263-271. doi: 10.1586/17446651.2014.897607
[3]	侯丽萍,刘祖霖,梁立阳. 正确认识新生儿高促甲状腺素血症[J]. 国际儿科学杂志,2013,40(3):290-293. doi: 10.3760/cma.j.issn.1673-4408.2013.03.022
[4]	Cuestas E,Gaido M I,Capra R H. Transient neonatal hyperthyrotropinemia is a risk factor for developing persistent hyperthyrotropinemia in childhood with repercussion on developmental status[J]. Eur J Endocrinol,2015,172(4):483-490. doi: 10.1530/EJE-13-0907
[5]	张骥,李杨. 新生儿先天性甲状腺功能减低症危险因素的Meta分析[J]. 中国当代儿科杂志,2021,23(5):505-512. doi: 10.7499/j.issn.1008-8830.2011121
[6]	Aguiar L,Garb J,Reiter E,et al. Can one predict resolution of neonatal hyperthyrotropinemia?[J]. J Pediatr,2016,174(5):71-77.
[7]	Mcgrath N,Hawkes C P,Mayne P,et al. Optimal timing of repeat newborn screening for congenital hypothyroidism in preterm infants to detect delayed thyroid-stimulating hormone elevation[J]. J Pediatr,2019,205(2):77-82.
[8]	叶可君,彭梦佳,戴洁,等. 妊娠期糖尿病与妊娠期高血压疾病患者甲状腺功能变化情况与临床干预研究[J]. 中国妇幼保健,2018,33(14):3142-3146.
[9]	邵肖梅, 叶鸿瑁, 丘小汕. 实用新生儿学[M]. 第5版. 北京: 人民卫生出版社, 2018: 394-396.
[10]	Cortes-Castell E,Juste M,Palazon-Bru A,et al. Factors associated with moderate neonatal hyperthyrotropinemia[J]. PLoS One,2019,14(7):220040.
[11]	王琼,齐志业,赵小龙,等. 云南省6州/市先天性甲状腺功能减低症筛查中TSH切值的确立[J]. 昆明医科大学学报,2018,39(1):69-72. doi: 10.3969/j.issn.1003-4706.2018.01.016
[12]	Raj S,Baburaj S,George J,et al. Cord blood TSH level variations in newborn - experience from a rural centre in southern India[J]. J Clin Diagn Res,2014,8(7):18-20.
[13]	Zhang Y,Du C,Wang W,et al. Effect of maternal and neonatal factors on neonatal thyroid stimulating hormone:Results from a population-based prospective cohort study in China[J]. J Trace Elem Med Biol,2018,49(9):151-156.
[14]	Tsiakkas A,Duvdevani N,Wright A,et al. Serum soluble fms-like tyrosine kinase-1 in the three trimesters of pregnancy:Effects of maternal characteristics and medical history[J]. Ultrasound Obstet Gynecol,2015,45(5):584-590. doi: 10.1002/uog.14817
[15]	Yang Y,Zhang Y,Cao Z,et al. Anti-VEGF- and anti-VEGF receptor-induced vascular alteration in mouse healthy tissues[J]. Proc Natl Acad Sci USA,2013,110(29):12018-12023. doi: 10.1073/pnas.1301331110
[16]	罗春伟,赵德华,梁歌,等. 母亲相关因素与新生儿先天性甲状腺功能减低症易感性的病例对照研究[J]. 中国当代儿科杂志,2020,22(1):37-41. doi: 10.7499/j.issn.1008-8830.2020.01.008
[17]	Wang Y,Wu X,Hong K,et al. Establishment of reference intervals for thyroid hormones in premature infants beyond the first week of life using Beckman Coulter Unicel DxI 800[J]. Clin Biochem,2019,74(9):19-23.
[18]	Di Dalmazi G,Carlucci M A,Semeraro D,et al. A detailed analysis of the factors influencing neonatal TSH:Results from a 6-year congenital hypothyroidism screening program[J]. Front Endocrinol (Lausanne),2020,11(7):456.
[19]	孙伟杰,杨慧霞. 妊娠期甲状腺疾病对胎儿及新生儿的影响:解读2017年美国甲状腺学会"妊娠期和产后甲状腺疾病诊治指南"[J]. 中华围产医学杂志,2017,20(11):779-782. doi: 10.3760/cma.j.issn.1007-9408.2017.11.003
[20]	Kaluarachchi D C,Allen D B,Eickhoff J C,et al. Thyroid-stimulating hormone reference ranges for preterm infants[J]. Pediatrics,2019,144(2):29.
[21]	刘爱玲,侯瑞英,姜萍. 低出生体重儿暂时性低甲状腺素血症相关因素的临床研究[J]. 潍坊医学院学报,2011,33(5):389-391.
[22]	Zhou J,Luo J,Lin J,et al. Perinatal risk factors for congenital hypothyroidism:A retrospective cohort study performed at a tertiary hospital in China[J]. Medicine (Baltimore),2020,99(26):151-156.
[23]	Eng L,Lam L. Thyroid function during the fetal and neonatal periods[J]. Neoreviews,2020,21(1):30-36. doi: 10.1542/neo.21-1-e30
[24]	梁钟智,于红松. 表观遗传学在自身免疫性甲状腺疾病中的研究进展[J]. 遵义医学院学报,2019,42(4):475-480. doi: 10.3969/j.issn.1000-2715.2019.04.022
[25]	Ramezani T F,Nazarpour S. Delivery factors and neonatal thyroid hormone levels:A systematic review[J]. J Pediatr Endocrinol Metab,2021,34(7):821-833. doi: 10.1515/jpem-2020-0740
[26]	Trumpff C,Vandevijvere S,Moreno-Reyes R,et al. Neonatal thyroid-stimulating hormone level is influenced by neonatal,maternal,and pregnancy factors[J]. Nutr Res,2015,35(11):975-981. doi: 10.1016/j.nutres.2015.09.002
[27]	Stoupa A,Kariyawasam D,Muzza M,et al. New genetics in congenital hypothyroidism[J]. Endocrine,2021,71(3):696-705. doi: 10.1007/s12020-021-02646-9

Relative Articles(20)

Relative Articles

[1]	Li DENG, Linhai CONG, Hongli FANG, Huifang GAO, Jiazhi YIN. Research Progress on Common Deafness Gene Screening in Chinese Newborns. Journal of Kunming Medical University, 2024, 44(1B): 1-3.
[2]	Wenlin ZHOU, Ben NIU, Heng SU. Analysis of Clinical Risk Factors for Idiopathic Hypogonadotropic Hypogonadism. Journal of Kunming Medical University, 2023, 44(7): 64-68. doi: 10.12259/j.issn.2095-610X.S20230727
[3]	Yuqing XIE, Jun WANG, Xuebi JI, Ping WANG, Haifeng WANG, Xumin LI, Linya HUANG. Research Progress on Risk Factors and Risk Assessment of Urinary Tract Infection in Patients with Ureterostomy. Journal of Kunming Medical University, 2023, 44(11): 158-163. doi: 10.12259/j.issn.2095-610X.S20231124
[4]	Tuan LI, Yu’e ZHOU, Yue LI. Application of White Noise in Neonatal Peripheral Venipuncture Pain. Journal of Kunming Medical University, 2023, 44(3): 167-171. doi: 10.12259/j.issn.2095-610X.S20230310
[5]	Jie WU, Jun LIU, Yan ZHANG, Xudong DONG, Xingzi FENG, Qinnan LU, Lingyan LIU. Analysis on the Trend of Birth Weight of 36551 Newborns in Last Ten Years. Journal of Kunming Medical University, 2022, 43(4): 75-81. doi: 10.12259/j.issn.2095-610X.S20220414
[6]	Huajie WU, Nan ZHANG, Lei LI, Han QIAO, Guoping LI. Research Progress in the Risk Factors and Prevention Strategies of Thyroid Cancer. Journal of Kunming Medical University, 2022, 43(5): 162-167. doi: 10.12259/j.issn.2095-610X.S20220526
[7]	Jing WANG, Lian-fang TANG, Mei-qun GU, Xiao-yan XU, Jian-hua YU, Shan HE, Zi-wei LI, Kai BI, Li-qiao LIU, Qiong ZHAO, Hong-ying MI. Risk Factors and Early Clinical Characteristics of Neonatal Necrotizing Enterocolitis. Journal of Kunming Medical University, 2021, 42(11): 99-104. doi: 10.12259/j.issn.2095-610X.S20211118
[8]	Yang Hui Bo , Yu Run Liu , Miao Qin , Liu De Liang . . Journal of Kunming Medical University, 2020, 41(07): 144-148.
[9]	Bi Yan , Gan Yuan , Gao Lan , Liu Fang , Lei Hong Tao , Zhou Qing , Tang Song Yuan . . Journal of Kunming Medical University, 2019, 40(01): 34-39.
[10]	Jiang Yu Hui , Liu Ling , He Can Lin , Li Yang . . Journal of Kunming Medical University, 2019, 40(04): 20-22.
[11]	Dai Mei . Risk Factors for Asthma in Children in Kunming City， China. Journal of Kunming Medical University,
[12]	Zhang Yi . . Journal of Kunming Medical University,
[13]	Tian Yun Fen . . Journal of Kunming Medical University,
[14]	Yang Ze Xing . . Journal of Kunming Medical University,
[15]	Ma Min . . Journal of Kunming Medical University,
[16]	Fei Xian Min . . Journal of Kunming Medical University,
[17]	Wen Yong . . Journal of Kunming Medical University,
[18]	. . Journal of Kunming Medical University,
[19]	. A Case-control Study on the Risk Factors of Maternal Mortality in Rural Areas of Yunnan Province. Journal of Kunming Medical University,
[20]	Yang Qiu Ping . . Journal of Kunming Medical University,